February 2010

Cholesterol inhibits M-type K+ channels via PKC-dependent phosphorylation in sympathetic neurons
Seul -Yi Lee, Hyun-Kyung Choi, Seong-Tae Kim, Sungkwon Chung, Myoung Kyu Park, Jung-Hwa Cho, Won-Kyung Ho, and Hana Cho
J. Biol. Chem. published 1 February 2010, 10.1074/jbc.M109.048868 [Abstract] [PDF]

Gonadotropin-induced ovarian cancer cell migration and proliferation require ERK1/2 activation regulated by calcium and protein kinase C{delta}
Inga Mertens-Walker, Christine Bolitho, Robert Baxter, and Deborah Marsh
Endocr. Relat. Cancer. published 5 February 2010, 10.1677/ERC-09-0152 [Abstract] [PDF]

SSeCKS/Gravin/AKAP12 Inhibits Cancer Cell Invasiveness and Chemotaxis by Suppressing a Protein Kinase C- Raf/MEK/ERK Pathway
Bing Su, Yahao Bu, David Engelberg, and Irwin H. Gelman
J. Biol. Chem. 2010; 285:4578-4586. [Abstract]

Activation of the Integrin Effector Kinase Focal Adhesion Kinase in Cancer Cells Is Regulated by Crosstalk between Protein Kinase C{alpha} and the PDZ Adapter Protein mda-9/Syntenin
Cheol Hwangbo, Jaekyung Kim, Jung Joon Lee, and Jeong-Hyung Lee
Cancer Res. published 9 February 2010, 10.1158/0008-5472.CAN-09-2447 [Abstract]

Synthetic Lethality Induced by Loss of PKC{delta} and Mutated Ras
Tongbo Zhu, Lihua Chen, Wei Du, Takanori Tsuji, and Changyan Chen
Genes & Cancer. published 10 February 2010, 10.1177/1947601909360989 [Abstract]

T47D/PKC{alpha} Cells Are Nonmigratory and Noninvasive In Vitro Despite Tamoxifen Resistance In Vivo.
B. Perez White and D. Tonetti
Cancer Res. 2009; 69:6173. [Abstract]

2-(4-Hydroxyphenyl)-Benzo[b]thiophen-6-ol, an Estrogen-Like Compound, Induces Apoptosis in T47D/PKC{alpha} Breast Cancer Cells.
M. Molloy, G. Thatcher, J. Bolton, and D. Tonetti
Cancer Res. 2009; 69:5140. [Abstract]

The regulatory domain of protein kinase C delta positively regulates insulin receptor signaling
Avraham I Jacob, Miriam Horovitz-Fried, Shlomit Aga-Mizrachi, Tamar Brutman-Barazani, Hana Okhrimenko, Yehiel Zick, Chaya Brodie, and Sanford R Sampson
J. Mol. Endocrinol. 2010; 44:155-169. [Abstract]

Constitutive Endocytic Recycling and Protein Kinase C-mediated Lysosomal Degradation Control KATP Channel Surface Density
Paul T. Manna, Andrew J. Smith, Tarvinder K. Taneja, Gareth J. Howell, Jonathan D. Lippiat, and Asipu Sivaprasadarao
J. Biol. Chem. 2010; 285:5963-5973. [Abstract]

Protein Kinase C{zeta} Mediates Cigarette Smoke/Aldehyde- and Lipopolysaccharide-induced Lung Inflammation and Histone Modifications
Hongwei Yao, Jae-woong Hwang, Jorge Moscat, Maria T. Diaz-Meco, Michael Leitges, Nandini Kishore, Xiong Li, and Irfan Rahman
J. Biol. Chem. 2010; 285:5405-5416. [Abstract]

Vascular endothelial growth factor stimulates protein kinase CβII expression in chronic lymphocytic leukaemia cells
Simon T. Abrams, Benjamin R.B. Brown, Mirko Zuzel, and Joseph R. Slupsky
Blood. published 17 February 2010, 10.1182/blood-2009-06-229872 [Abstract] [PDF]

Protein kinase C delta and eta differently regulate the expression of loricrin and Jun family proteins in human keratinocytes.
Kamioka N, Akahane T, Kohno Y, et al.
Biochem Biophys Res Commun, 2010.
[Full Text] [PDF]

Protein Kinase C{iota} Is Required for Pancreatic Cancer Cell Transformed Growth and Tumorigenesis.
Scotti ML, Bamlet WR, Smyrk TC, Fields AP, Murray NR.
Cancer Res;70(5):2064-74, 2010. [Abstract]

Protection from rapamycin-induced apoptosis by insulin-like growth factor-I is partially dependent on protein kinase C signaling.
Thimmaiah KN, Easton JB, Houghton PJ.
Cancer Res;70(5):2000-9, 2010. [Abstract]

Dehdyroepiandrosterone Sulfate Directly Activates Protein Kinase C-{beta} to Increase Human Neutrophil Superoxide Generation.
Radford DJ, Wang K, McNelis JC, et al.
Mol Endocrinol, 2010. [Abstract] [PDF]

Regulation of cell adhesion to collagen via beta1 integrins is dependent on interactions of filamin A with vimentin and protein kinase C epsilon.
Kim H, Nakamura F, Lee W, Hong C, Perez-Sala D, McCulloch CA.
Exp Cell Res, 2010. [Full Text] [PDF]

Protective effects of hypoxia-inducible factor-1alpha on myocardial ischemia/reperfusion injury in rat and the role of protein kinase C in signal pathway.
Niu TS, Qi GX, Fu P, Sun YX, 2010.
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue;22(2):101-4. [Abstract]

Rapid, transient effects of the protein kinase C activator phorbol 12-myristate 13-acetate on activity and trafficking of the rat high-affinity choline transporter.
Black SA, Ribeiro FM, Ferguson SS, Rylett RJ.
Neuroscience, 2010. [Abstract] [Full Text] [PDF]

Vascular endothelial growth factor stimulates protein kinase C{beta}II expression in chronic lymphocytic leukaemia cells.
Abrams ST, Brown BR, Zuzel M, Slupsky JR
Blood, 2010. [Abstract]

p23/Tmp21 Differentially Targets the Rac-GAP {beta}2-Chimaerin and Protein Kinase C via their C1 Domains.
Wang H, Kazanietz MG.
Mol Biol Cell, 2010. [Abstract]

Phosphorylation of cardiac troponin I at protein kinase C site threonine-144 depresses cooperative activation of thin filaments.
Lu QW, Hinken AC, Patrick SE, Solaro RJ, Kobayashi T.
J Biol Chem, 2010. [Abstract] [PDF]

Rapid modulation of the organic anion transporting polypeptide 2B1 (OATP2B1, SLCO2B1) function by protein kinase C-mediated internalization.
Kock K, Koenen A, Giese B, et al.
J Biol Chem, 2010. [Abstract] [PDF]

Upregulation of cytoplasmic gelsolin, an amyloid-beta-binding protein, under oxidative stress conditions: involvement of protein kinase C.
Ji L, Chauhan A, Chauhan V.
J Alzheimers Dis;19(3):829-38, 2010. [Abstract] [Full Text] [PDF]

Protein kinase C-delta is involved in the inflammatory effect of IL-6 in mouse adipose cells.
Wallerstedt E, Smith U, Andersson CX.
Diabetologia, 2010. [Abstract] [Full Text] [PDF]

Hydrogen sulfide protects neurons against hypoxic injury via stimulation of ATP-sensitive potassium channel/protein kinase C/extracellular signal-regulated kinase/heat shock protein90 pathway.
Tay AS, Hu LF, Lu M, Wong PT, Bian JS.
Neuroscience, 2010. [Abstract] [Full Text] [PDF]

Stimulation of protein kinase C-alpha suppresses colon cancer cell proliferation by down-regulation of beta-catenin.
Gwak J, Jung SJ, Kang DI, et al.
J Cell Mol Med 2009;13(8B):2171-80, 2010. [Abstract] [Full Text] [PDF]

Protein kinase C-delta is involved in the inflammatory effect of IL-6 in mouse adipose cells.
Wallerstedt E, Smith U, Andersson CX.
Diabetologia, 2010. [Abstract] [Full Text] [PDF]

Chemical Biology Strategy Reveals Pathway-Selective Inhibitor of NF-kappaB Activation Induced by Protein Kinase C.
Shi R, Re D, Dudl E, et al.
ACS Chem Biol, 2010. [Abstract] [Full Text] [PDF]

Regulation of Human Organic Anion Transporter 4 by Protein Kinase C and NHERF-1: Altering the Endocytosis of the Transporter.
Zhang Q, Pan Z, You G.
Pharm Res, 2010. [Abstract] [Full Text] [PDF]

Glutamate induces neurotrophic factor production from microglia via protein kinase C pathway.
Liang J, Takeuchi H, Jin S, et al.
Brain Res, 2010. [Abstract] [Full Text] [PDF]

Redox Control of Protein Kinase C: Cell and Disease Specific Aspects.
Giorgi C, Agnoletto C, Baldini C, et al.
Antioxid Redox Signal, 2010. [Abstract] [PDF]

Vital role of protein kinase C-related kinase in the formation and stability of neurites during hypoxia.
Thauerer B, Zur Nedden S, Baier-Bitterlich G.
J Neurochem, 2010. [Abstract] [Full Text] [PDF]

Renoprotective and blood pressure-lowering effect of dietary soy protein via protein kinase C betaII inhibition in a rat model of metabolic syndrome.
Palanisamy N, Viswanathan P, Ravichandran MK, Anuradha CV.
Can J Physiol Pharmacol;88(1):28-37, 2010. [Abstract] [PDF]

Arsenic trioxide-mediated antiplatelet activity: pivotal role of the phospholipase C gamma 2-protein kinase C-p38 MAPK cascade.
Lin KH, Chang YF, Fan CY, et al.
Transl Res;155(2):97-108, 2010. [Abstract]

Ret-PCP2 colocalizes with protein kinase C in a subset of primate ON cone bipolar cells.
Sulaiman P, Fina M, Feddersen R, Vardi N.
J Comp Neurol;518(7):1098-112, 2010. [Abstract] [Full Text] [PDF]

Sotrastaurin, a Novel Small Molecule Inhibiting Protein Kinase C: First Clinical Results in Renal-Transplant Recipients.
Budde K, Sommerer C, Becker T, et al.
Am J Transplant, 2010. [Abstract] [Full Text] [PDF]