The platelet protein kinase C substrate pleckstrin binds directly to SDPR protein.
Baig A, Bao X, Wolf M, Haslam RJ.
Platelets 2009. [Abstract] [Full Text] [PDF]

ATPase Class I Type 8B Member 1 and Protein Kinase C-zeta Induce the Expression of the Canalicular Bile Salt Export Pump in Human Hepatocytes.
Chen F, Ellis E, Strom SC, Shneider BL.
Pediatr Res 2009. [Abstract]

Inhibition of protein kinase C-beta by ruboxistaurin preserves cardiac function and reduces extracellular matrix production in diabetic cardiomyopathy.
Connelly KA, Kelly DJ, Zhang Y, Prior DL, Advani A, Cox AJ, et al.
Circ Heart Fail 2009. [Abstract]

Differential regulation of p53 function by protein kinase C isoforms revealed by a yeast cell system.
Coutinho I, Pereira G, Leao M, Goncalves J, Corte-Real M, Saraiva L.
FEBS Lett 2009. [Full Text] [PDF]

Protein kinase C is involved in the regulation of several calreticulin posttranslational modifications.
Cristina Castaneda-Patlan M, Razo-Paredes R, Carrisoza-Gaytan R, Gonzalez-Mariscal L, Robles-Flores M.
Int J Biochem Cell Biol 2009. [Full Text] [PDF]

Diverse roles for protein kinase C delta and protein kinase C epsilon in the generation of high-fat-diet-induced glucose intolerance in mice: regulation of lipogenesis by protein kinase C delta.
Frangioudakis G, Burchfield JG, Narasimhan S, Cooney GJ, Leitges M, Biden TJ, Schmitz-Peiffer C.
Diabetologia 2009. [Full_Text] [PDF]

Discovery of a novel class of targeted kinase inhibitors that blocks protein kinase C signaling and ameliorates retinal vascular leakage in a diabetic rat model.
Grant S, Tran P, Zhang Q, Zou A, Dinh D, Jensen J, et al.
Eur J Pharmacol 2009. [Full Text] [PDF]

Inhibition of protein kinase C signaling protects prefrontal cortex dendritic spines and cognition from the effects of chronic stress.
Hains AB, Vu MA, Maciejewski PK, van Dyck CH, Gottron M, Arnsten AF.
Proc Natl Acad Sci U S A 2009. [Abstract] [Full Text] [PDF]

Signaling Cascade of Diacylglycerol Kinase {beta} in the Pituitary Intermediate Lobe: Dopamine D2 Receptor/ Phospholipase C{beta}4/ Diacylglycerol Kinase {beta}/ Protein Kinase C{alpha}.
Hozumi Y, Watanabe M, Goto K.
J Histochem Cytochem 2009. [Abstract]

Mechanisms of inhibition of T-type calcium current in the reticular thalamic neurons by 1-octanol: implication of the protein kinase C pathway.
Joksovic PM, Choe WJ, Nelson MT, Orestes P, Brimelow BC, Todorovic SM.
Mol Pharmacol 2009. [Abstract] [Full Text] [PDF]

Caspase-mediated protein kinase C-delta cleavage is necessary for apoptosis of vascular smooth muscle cells.
Kato K, Yamanouchi D, Esbona K, Kamiya K, Zhang F, Kent KC, Liu B.
Am J Physiol Heart Circ Physiol 2009. [Abstract]

Kinase-activity-independent functions of atypical protein kinase C in Drosophila.
Kim S, Gailite I, Moussian B, Luschnig S, Goette M, Fricke K, et al.
J Cell Sci 2009. [Abstract] [Full Text] [PDF]

Reactive oxygen species-generating mitochondrial DNA mutation up-regulates hypoxia-inducible factor-1alpha gene transcription via phosphatidylinositol 3-kinase-Akt/protein kinase C/histone deacetylase pathway.
Koshikawa N, Hayashi J, Nakagawara A, Takenaga K.
J Biol Chem 2009. [Abstract]

Reduction of beta-amyloid levels by novel protein kinase C(epsilon) activators.
Nelson TJ, Cui C, Luo Y, Alkon DL.
J Biol Chem 2009. [Abstract]

Overproduction of phosphoprotein enriched in diabetes (PED) induces mesangial expansion and upregulates protein kinase C-beta activity and TGF-beta1 expression.
Oriente F, Iovino S, Cassese A, Romano C, Miele C, Troncone G, et al.
Diabetologia 2009. [Full Text] [PDF]

Protein kinase C mediates the synergistic interaction between agonists acting at alpha2-adrenergic and delta-opioid receptors in spinal cord.
Overland AC, Kitto KF, Chabot-Dore AJ, Rothwell PE, Fairbanks CA, Stone LS, Wilcox GL.
J Neurosci 2009. [Full Text] [PDF]

Protein kinase C-mediated inhibition of recombinant T-type Ca V 3.2 channels by neurokinin 1 receptors.
Rangel A, Sanchez-Armass S, Meza U.
Mol Pharmacol 2009. [Abstract] [PDF]

Protein kinase C mediated high glucose effect on adenosine receptors expression in rat B lymphocytes.
Sakowicz-Burkiewicz M, Kocbuch K, Grden M, Szutowicz A, Pawelczyk T.
J Physiol Pharmacol 2009. [PDF]

Involvement of protein kinase C-CPI-17 in androgen modulation of angiotensin II-renal vasoconstriction.
Song J, Eyster KM, Kost CK, Jr., Kjellsen B, Martin DS.
Cardiovasc Res 2009.[Full Text] [PDF]

Atypical protein kinase C activity in the hypothalamus is required for lipopolysaccharide-mediated sickness responses.
Thaler JP, Choi SJ, Sajan MP, Ogimoto K, Nguyen HT, Matsen M, et al.
Endocrinology 2009. [Abstract] [Full Text] [PDF]

Breast cancer-derived factors stimulate osteoclastogenesis through the Ca2+/protein kinase C and transforming growth factor-beta/MAPK signaling pathways.
Tiedemann K, Hussein O, Sadvakassova G, Guo Y, Siegel PM, Komarova SV.
J Biol Chem 2009. [Abstract]

Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5 -dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes.
Wagner J, von Matt P, Sedrani R, Albert R, Cooke N, Ehrhardt C, et al.
J Med Chem 2009. [Abstract] [Full Text] [PDF]

Carbachol-induced rabbit bladder smooth muscle contraction: roles of protein kinase C and Rho kinase.
Wang T, Kendig DM, Smolock EM, Moreland RS.
Am J Physiol Renal Physiol 2009. [Abstract] [Full Text] [PDF]

Protein kinase C delta mediates arterial injury responses through regulation of vascular smooth muscle cell apoptosis.
Yamanouchi D, Kato K, Ryer EJ, Zhang F, Liu B.
Cardiovasc Res 2009. [Abstract] [Full Text] [PDF]

Propofol inhibits aquaporin 4 expression through a protein kinase C-dependent pathway in an astrocyte model of cerebral ischemia/reoxygenation.
Zhu SM, Xiong XX, Zheng YY, Pan CF.
Anesth Analg 2009. [Abstract] [Full Text] [PDF]

Ionizing Radiation Induces Apoptotic Signal Through Protein Kinase C (delta) and Survival Signal Through Akt and Cyclic-Nucleotide Response Element-Binding Protein (CREB) in Jurkat T Cells
Amelia Cataldi, Viviana Di Giacomo, Monica Rapino, Susi Zara, and Rosa Alba Rana
Biol. Bull. 2009; 217:202-212. [Abstract]

Closed-state inactivation in Kv4.3 isoforms is differentially modulated by protein kinase C
Chang Xie, Vladimir E. Bondarenko, Michael J. Morales, and Harold C. Strauss
Am J Physiol Cell Physiol. 2009; 297:C1236-C1248. [Abstract]

Translational Control of Protein Kinase C{eta} by Two Upstream Open Reading Frames
Hadas Raveh-Amit, Adva Maissel, Jonathan Poller, Liraz Marom, Orna Elroy-Stein, Michal Shapira, and Etta Livneh
Mol. Cell. Biol. 2009; 29:6140-6148. [Abstract] [Full Text] [PDF]

Cigarette smoke extract induces COX-2 expression via a PKC{alpha}/c-Src/EGFR, PDGFR/PI3K/Akt/NF{kappa}-B pathway and p300 in tracheal smooth muscle cells
Chuen-Mao Yang, I-Ta Lee, Chih-Chung Lin, Ya-Lin Yang, Shue-Fen Luo, Yu Ru Kou, and Li-Der Hsiao
Am J Physiol Lung Cell Mol Physiol. 2009; 297:L892-L902. [Abstract]

12-O-Tetradecanoylphorbol-13-acetate Inhibits Melanoma Growth by Inactivation of STAT3 through Protein Kinase C-activated Tyrosine Phosphatase(s)
Masahiro Oka, Naoko Sumita, Masanobu Sakaguchi, Tetsushi Iwasaki, Toshinori Bito, Toshiro Kageshita, Ken-ichi Sato, Yasuo Fukami, and Chikako Nishigori
J. Biol. Chem. 2009; 284:30416-30423. [Abstract]

The IGF-I Receptor Can Alter the Matrix Metalloproteinase Repertoire of Tumor Cells through Transcriptional Regulation of PKC-{alpha}
Shun Li, Donglei Zhang, Long Yang, Julia V. Burnier, Ni Wang, Rongtuan Lin, Eunice R. Lee, Robert I. Glazer, and Pnina Brodt
Mol. Endocrinol. published 23 October 2009, 10.1210/me.2009-0197 [Abstract] [PDF]

Involvement of protein kinase C-CPI-17 in androgen modulation of angiotensin II-renal vasoconstriction
Jin Song, Kathleen M. Eyster, Curtis K. Kost, Jr, Barton Kjellsen, and Douglas S. Martin
Cardiovasc Res. published 23 October 2009, 10.1093/cvr/cvp326 [Abstract] [Full Text] [PDF]

H3 Histamine Receptor?Mediated Activation of Protein Kinase C{alpha} Inhibits the Growth of Cholangiocarcinoma In vitro and In vivo
Heather Francis, Paolo Onori, Eugenio Gaudio, Antonio Franchitto, Sharon DeMorrow, Julie Venter, Shelley Kopriva, Guido Carpino, Romina Mancinelli, Mellanie White, Fanyin Meng, Antonella Vetuschi, Roberta Sferra, and Gianfranco Alpini
Mol. Cancer Res. 2009; 7:1704-1713. [Abstract]

Regulation of the Interaction between Protein Kinase C-related Protein Kinase 2 (PRK2) and Its Upstream Kinase, 3-Phosphoinositide-dependent Protein Kinase 1 (PDK1)
Rosalia Dettori, Silvina Sonzogni, Lucas Meyer, Laura A. Lopez-Garcia, Nick A. Morrice, Stefan Zeuzem, Matthias Engel, Albrecht Piiper, Sonja Neimanis, Morten Frodin, and Ricardo M. Biondi
J. Biol. Chem. 2009; 284:30318-30327. [Abstract]

Reduction of beta-amyloid levels by novel PKCepsilon activators
Thomas J. Nelson, Changhai Cui, Yuan Luo, and Daniel L. Alkon
J. Biol. Chem. published 22 October 2009, 10.1074/jbc.M109.016683 [Abstract] [PDF]

Protein Kinase C Mediates the Synergistic Interaction Between Agonists Acting at {alpha}2-Adrenergic and Delta-Opioid Receptors in Spinal Cord
Aaron C. Overland, Kelley F. Kitto, Anne-Julie Chabot-Dore, Patrick E. Rothwell, Carolyn A. Fairbanks, Laura S. Stone, and George L. Wilcox
J. Neurosci. 2009; 29:13264-13273. [Abstract] [Full Text] [PDF]

Mechanisms of inhibition of T-type calcium current in the reticular thalamic neurons by 1-octanol: implication of the protein kinase C pathway
Pavle M Joksovic, WonJoo Choe, Michael T Nelson, Peihan Orestes, Barbara C Brimelow, and Slobodan M Todorovic
Mol. Pharmacol. published 21 October 2009, 10.1124/mol.109.059931 [Abstract] [PDF]

PPARβ/{delta} Agonists Modulate Platelet Function via a Mechanism Involving PPAR Receptors and Specific Association/Repression of PKC{alpha}?Brief Report
Ferhana Y. Ali, Matthew G. Hall, Beatrice Desvergne, Timothy D. Warner, and Jane A. Mitchell
Arterioscler Thromb Vasc Biol. 2009; 29:1871-1873. [Abstract] [Full Text] [PDF]

A role for PKC in mediating stress-induced prefrontal cortical structural plasticity and cognitive function
Guang Chen, Ioline D. Henter, and Husseini K. Manji
PNAS. 2009; 106:17613-17614. [Extract]

Aortic arginine transport is attenuated, through post-translational modulation of CAT-1 by PKC{alpha}, in old male rats
Idit F Schwartz, Tamara Chernichovski, and Doron Schwartz
Vascular Medicine. published 20 October 2009, 10.1177/1358863X09346659 [Abstract] [PDF]

Inhibition of protein kinase C signaling protects prefrontal cortex dendritic spines and cognition from the effects of chronic stress
Avis Brennan Hains, Mai Anh T. Vu, Paul K. Maciejewski, Christopher H. van Dyck, Melissa Gottron, and Amy F. T. Arnsten
PNAS. 2009; 106:17957-17962. [Abstract] [Full Text] [PDF]

Propofol Inhibits Aquaporin 4 Expression Through a Protein Kinase C?Dependent Pathway in an Astrocyte Model of Cerebral Ischemia/Reoxygenation
Sheng-Mei Zhu, Xiao-Xing Xiong, Yue-Ying Zheng, and Cai-Fei Pan
Anesth. Analg. 2009; 109:1493-1499. [Abstract]

Excitatory Roles of Protein Kinase C in Striatal Cholinergic Interneurons
Ping Deng, Zhi-Ping Pang, Zhigang Lei, and Zao C. Xu
J Neurophysiol. 2009; 102:2453-2461. [Abstract]

Warm-blood cardioplegic arrest induces selective mitochondrial translocation of protein kinase C{epsilon} followed by interaction with 6.1 inwardly rectifying potassium channel subunit in viable myocytes overexpressing urocortin
Carol Chen-Scarabelli, Giuseppe Faggian, Zhaokan Yuan, Maddalena Tessari, Alessio Rungatscher, Justin Di Rezze, Gabriele M. Scarabelli, Kadija Abounit, Roy McCauley, Louis Saravolatz, Alessandro Mazzucco, and Tiziano M. Scarabelli
J. Thorac. Cardiovasc. Surg. 2009; 138:1213-1221. [Abstract]

Caspase-mediated Protein Kinase C-Delta cleavage is necessary for apoptosis of Vascular Smooth Muscle Cells
Kaori Kato, Dai Yamanouchi, Karla Esbona, Kentaro Kamiya, Fan Zhang, K. Craig Kent, and Bo Liu
Am J Physiol Heart Circ Physiol. published 16 October 2009, 10.1152/ajpheart.00274.2009 [Abstract]

Androgens Induce Dopaminergic Neurotoxicity via Caspase-3-Dependent Activation of Protein Kinase C{delta}
Rebecca L. Cunningham, Andrea Giuffrida, and James L. Roberts
Endocrinology. published 16 October 2009, 10.1210/en.2009-0640 [Abstract]

PKC{delta} supports survival of MDA-MB-231 breast cancer cells by suppressing the ERK1/2 pathway
Gry Kalstad Lonne, Katarzyna Chmielarska Massoumi, Johan Lennartsson, and Christer Larsson
J. Biol. Chem. published 15 October 2009, 10.1074/jbc.M109.036186 [Abstract] [PDF]

A role for PKC in mediating stress-induced prefrontal cortical structural plasticity and cognitive function
Guang Chen, Ioline D. Henter, and Husseini K. Manji
PNAS. published 14 October 2009, 10.1073/pnas.0909771106 [PDF]

Over-expression of kinase negative protein kinase C{delta} in pancreatic β-cells protects mice from diet-induced glucose intolerance and β-cell dysfunction
Anita M. Hennige, Felicia Ranta, Isabel Heinzelmann, Martina Dufer, Diana Michael, Heidi Braumuller, Stefan Z. Lutz, Reiner Lammers, Gisela Drews, Fatima Bosch, Hans-Ulrich Haring, and Susanne Ullrich
Diabetes. published 13 October 2009, 10.2337/db09-0512 [Abstract] [PDF]

H3 Histamine Receptor?Mediated Activation of Protein Kinase C{alpha} Inhibits the Growth of Cholangiocarcinoma In vitro and In vivo
Heather Francis, Paolo Onori, Eugenio Gaudio, Antonio Franchitto, Sharon DeMorrow, Julie Venter, Shelley Kopriva, Guido Carpino, Romina Mancinelli, Mellanie White, Fanyin Meng, Antonella Vetuschi, Roberta Sferra, and Gianfranco Alpini
Mol. Cancer Res. published 13 October 2009, 10.1158/1541-7786.MCR-09-0261 [Abstract]

Signaling Cascade of Diacylglycerol Kinase{beta} in the Pituitary Intermediate Lobe: Dopamine D2 Receptor/ Phospholipase C{beta}4/ Diacylglycerol Kinase{beta} / Protein Kinase C{alpha}
Yasukazu Hozumi, Masahiko Watanabe, and Kaoru Goto
J. Histochem. Cytochem. published 13 October 2009, 10.1369/jhc.2009.954347 [Abstract]

Ischemic preconditioning improves proteasomal activity and increases the degradation of {delta}PKC during reperfusion
Eric N. Churchill, Julio C. Ferreira, Patricia C. Brum, Luke I. Szweda, and Daria Mochly-Rosen
Cardiovasc Res. published 10 October 2009, 10.1093/cvr/cvp334 [Abstract] [PDF]

Atypical Protein Kinase C Activity in the Hypothalamus Is Required for Lipopolysaccharide-Mediated Sickness Responses
Joshua P. Thaler, Sun Ju Choi, Mini P. Sajan, Kayoko Ogimoto, Hong T. Nguyen, Miles Matsen, Stephen C. Benoit, Brent E. Wisse, Robert V. Farese, and Michael W. Schwartz
Endocrinology. published 9 October 2009, 10.1210/en.2009-0509 [Abstract] [PDF]

Kinase-activity-independent functions of atypical protein kinase C in Drosophila
Soya Kim, Ieva Gailite, Bernard Moussian, Stefan Luschnig, Maik Goette, Karen Fricke, Mona Honemann-Capito, Helmut Grubmuller, and Andreas Wodarz
Development. 2009; 136:e1. [Full Text]

Phosphorylation of endothelial nitric oxide synthase by atypical PKC{zeta} contributes to angiopoietin-1?dependent inhibition of VEGF-induced endothelial permeability in vitro
Malika Oubaha and Jean-Philippe Gratton
Blood. 2009; 114:3343-3351. [Abstract] [Full Text] [PDF]

PKC{epsilon} DEPENDENT AND INDEPENDENT EFFECTS OF TAUROLITHOCHOLATE ON PI3K/PKB PATHWAY AND TAUROCHOLATE UPTAKE IN HUH-NTCP CELL LINE
Christopher M. Schonhoff, Ai Yamazaki, Simon Hohenester, Cynthia RL Webster, Bernard Bouscarel, and M. Sawkat Anwer
Am J Physiol Gastrointest Liver Physiol. published 8 October 2009, 10.1152/ajpgi.00177.2009 [Abstract] [PDF]

Protein kinase C-mediated inhibition of recombinant T-type Ca V 3.2 channels by neurokinin 1 receptors
Azahel Rangel, Sergio Sanchez-Armass, and Ulises Meza
Mol. Pharmacol. published 5 October 2009, 10.1124/mol.109.058727 [Abstract] [PDF]

PKC-permitted elevation of sarcolemmal KATP concentration may explain female-specific resistance to myocardial infarction
Andrew G Edwards, Meredith L Rees, Rachel A Gioscia, Derek K Zachman, Joshua M Lynch, Jason C Browder, Adam J Chicco, and Russell L Moore
J. Physiol. published 5 October 2009, 10.1113/jphysiol.2009.181040 [Abstract]

Regulation of TNF-induced oxygen radical production in human neutrophils: role of {delta}-PKC
Laurie E. Kilpatrick, Shuang Sun, Haiying Li, Thomas C. Vary, and Helen M. Korchak
J. Leukoc. Biol. published 2 October 2009, 10.1189/jlb.0408230 [Abstract]

Atypical Protein Kinase C{iota} Is Required for Bronchioalveolar Stem Cell Expansion and Lung Tumorigenesis
Roderick P. Regala, Rebecca K. Davis, Alyssa Kunz, Andras Khoor, Michael Leitges, and Alan P. Fields
Cancer Res. 2009; 69:7603-7611. [Abstract] [Full Text] [PDF]

Lyn, PKC-{delta}, SHIP-1 interactions regulate GPVI-mediated platelet-dense granule secretion
Ramya Chari, Soochong Kim, Swaminathan Murugappan, Archana Sanjay, James L. Daniel, and Satya P. Kunapuli
Blood. 2009; 114:3056-3063. [Abstract] [Full Text] [PDF]

ROS-generating mitochondrial DNA mutation upregulates hypoxia-inducible factor-1alpha gene transcription via PI3K-Akt/PKC/HDAC pathway
Nobuko Koshikawa, Jun-Ichi Hayashi, Akira Nakagawara, and Keizo Takenaga
J. Biol. Chem. published 1 October 2009, 10.1074/jbc.M109.054221 [Abstract] [PDF]

Lyn and PKC{delta} order SHIP1 embargo
Ulhas P. Naik
Blood. 2009; 114:2856-2857. [Full Text] [PDF]

PKC induces internalization and retention of the EAAC1 glutamate transporter in recycling endosomes of MDCK cells
Valeria Padovano, Silvia Massari, Silvia Mazzucchelli, and Grazia Pietrini (1 October 2009)
Am J Physiol Cell Physiol 297 (4), C835. [DOI: 10.1152/ajpcell.00212.2009] [Abstract] [Full Text] [PDF]

Selective Inhibition of Protein Kinase C β2 Attenuates Inducible Nitric Oxide Synthase?Mediated Cardiovascular Abnormalities in Streptozotocin-Induced Diabetic Rats
Prabhakara Reddy Nagareddy, Hesham Soliman, Guorong Lin, Padmesh S. Rajput, Ujendra Kumar, John H. McNeill, and Kathleen M. MacLeod
Diabetes. 2009; 58:2355-2364. [Abstract] [Full Text] [PDF]