September 2009

Evidence for rare and common genetic risk variants for schizophrenia at protein kinase C, alpha.
Carroll LS, Williams NM, Moskvina V, Russell E, Norton N, Williams HJ, et al.
Mol Psychiatry 2009. [Full Text] [PDF]

Protein kinase C-beta II expression in diffuse large B-cell lymphoma predicts for inferior outcome of anthracycline-based chemotherapy with and without rituximab.
Chaiwatanatorn K, Stamaratis G, Opeskin K, Firkin F, Nandurkar H.
Leuk Lymphoma 2009. [Full Text] [PDF]

Attenuation of renal ischemia-reperfusion injury by postconditioning involves adenosine receptor and protein kinase C activation.
Eldaif SM, Deneve JA, Wang NP, Jiang R, Mosunjac M, Mutrie CJ, et al.
Transpl Int 2009.[Abstract] [Full Text] [PDF]

Tumor-mediated inhibition of dendritic cell differentiation is mediated by down regulation of protein kinase C beta II expression.
Farren MR, Carlson LM, Lee KP.
Immunol Res 2009. [Full Text] [PDF]

Promising multifunctional anti-Alzheimer's dimer bis(7)-Cognitin acting as an activator of protein kinase C regulates activities of alpha-secretase and BACE-1 concurrently.
Fu H, Dou J, Li W, Cui W, Mak S, Hu Q, et al.
Eur J Pharmacol 2009. [Full Text] [PDF]

Protein kinase C-delta mediates down-regulation of heterogeneous nuclear ribonucleoprotein K protein: involvement in apoptosis induction.
Gao FH, Wu YL, Zhao M, Liu CX, Wang LS, Chen GQ.
Exp Cell Res 2009. [PDF]

Role of protein kinase C in functional selectivity for desensitization at the mu-opioid receptor: from pharmacological curiosity to therapeutic potential.
Ingram SL, Traynor JR.
Br J Pharmacol 2009. [Abstract] [Full Text] [PDF]

A-kinase anchoring protein 150 controls protein kinase C-mediated phosphorylation and sensitization of TRPV1.
Jeske NA, Patwardhan AM, Ruparel NB, Akopian AN, Shapiro MS, Henry MA.
Pain 2009. [Full Text] [PDF]

Killing of cancer cells by the photoactivatable protein kinase C inhibitor, calphostin C, involves induction of endoplasmic reticulum stress.
Kaul A, Maltese WA.
Neoplasia 2009. [PDF]

The membrane cytoskeletal protein adducin is phosphorylated by protein kinase C in D1 neurons of the nucleus accumbens and dorsal striatum following cocaine administration.
Lavaur J, Mineur YS, Picciotto MR.
J Neurochem 2009. [Abstract] [Full Text] [PDF]

Regulation of Rnd3 localization and function by protein kinase C alpha-mediated phosphorylation.
Madigan JP, Bodemann BO, Brady DC, Dewar BJ, Keller PJ, Leitges M, et al.
Biochem J 2009. [PDF]

Activation of cytosolic phospholipase A2alpha by epidermal growth factor (EGF) and phorbol ester in HeLa cells: different effects of inhibitors for EGF receptor, protein kinase C, Src, and C-Raf.
Matsuzawa Y, Kiuchi Y, Toyomura K, Matsumoto I, Nakamura H, Fujino H, et al.
J Pharmacol Sci 2009. [Abstract] [PDF]

Water permeability through aquaporin-4 is regulated by protein kinase C and becomes rate-limiting for glioma invasion.
McCoy ES, Haas BR, Sontheimer H.
Neuroscience 2009. [Full Text] [PDF]

Epidermal growth factor receptor variant III-induced glioma invasion is mediated through myristoylated alanine-rich protein kinase C substrate overexpression.
Micallef J, Taccone M, Mukherjee J, Croul S, Busby J, Moran MF, Guha A.
Cancer Res 2009. [Abstract] [Full Text] [PDF]

Involvement of protein kinase C in IL-1beta-induced expression of cyclooxygenase-2 in human gingival fibroblasts.
Nakao S, Inoue D.
J Oral Sci 2009. [PDF]

12-O-tetradecanoylphorbol-13-acetate inhibits melanoma growth by inactivation of STAT3 through protein kinase C-activated tyrosine phosphatase(s).
Oka M, Sumita N, Sakaguchi M, Iwasaki T, Bito T, Kageshita T, et al.
J Biol Chem 2009. [Abstract] [Full Text] [PDF]

Patented natural avocado sugars modulate the HBD-2 expression in human keratinocytes through the involvement of protein kinase C and protein tyrosine kinases.
Paoletti I, Buommino E, Tudisco L, Baudouin C, Msika P, Tufano MA, et al.
Arch Dermatol Res 2009. [Full Text] [PDF]

Atypical protein kinase C{iota} is required for bronchioalveolar stem cell expansion and lung tumorigenesis.
Regala RP, Davis RK, Kunz A, Khoor A, Leitges M, Fields AP.
Cancer Res 2009. [Abstract] [Full Text] [PDF]

The plasmodium receptor for activated C kinase protein inhibits Ca(2+) signaling in mammalian cells.
Sartorello R, Amaya MJ, Nathanson MH, Garcia CR.
Biochem Biophys Res Commun 2009. [Full Text] [PDF]

Protein kinase C-dependent upregulation of miR-203 induces the differentiation of human keratinocytes.
Sonkoly E, Wei T, Pavez Lorie E, Suzuki H, Kato M, Torma H, et al.
J Invest Dermatol, 2009. [Full_Text] [PDF]

Differential contributions of protein kinase C isoforms in the regulation of group IIA secreted phospholipase A(2) expression in cytokine-stimulated rat fibroblasts.
Sugita M, Kuwata H, Kudo I, Hara S.
Biochim Biophys Acta, 2009. [Full Text] [PDF]

High Expression of Atypical Protein Kinase C lambda/iota in Gastric Cancer as a Prognostic Factor for Recurrence.
Takagawa R, Akimoto K, Ichikawa Y, Akiyama H, Kojima Y, Ishiguro H, et al.
Ann Surg Oncol 2009. [Full Text] [PDF]

Calcineurin activation by slow calcium release from intracellular stores suppresses protein kinase C regulation of L-type calcium channels in L6 cells.
Turner JD, Thomas AP, Reeves JP, Hantash BM.
Cell Calcium 2009. [Full Text] [PDF]

Involvement of phosphatidylcholine-phospholipase C and protein kinase C in peptidoglycan-induced nuclear factor-kappaB activation and cyclooxygenase-2 expression in RAW 264.7 macrophages.
Tzeng JI, Chen BC, Chang HM, Wang JJ, Sureshbabu M, Chien MH, et al.
Pharmacol Res 2009. [Full Text] [PDF]

PKC Phosphorylation of Titin’s PEVK Element: A Novel and Conserved Pathway for Modulating Myocardial Stiffness
Carlos Hidalgo, Bryan Hudson, Julius Bogomolovas, Yi Zhu, Brian Anderson, Marion Greaser, Siegfried Labeit, and Henk Granzier
Circ. Res., Sep 2009; 105: 631 - 638. [Abstract] [Full Text] [PDF]

Regulation of intracerebral arteriolar tone by Kv channels: effects of glucose and PKC
Stephen V. Straub, Helene Girouard, Paul E. Doetsch, Rachael M. Hannah, M. Keith Wilkerson, and Mark T. Nelson
Am J Physiol Cell Physiol, Sep 2009; 297: C788 - C796. [Abstract]

Kinase-activity-independent functions of atypical protein kinase C in Drosophila
Soya Kim, Ieva Gailite, Bernard Moussian, Stefan Luschnig, Maik Goette, Karen Fricke, Mona Honemann-Capito, Helmut Grubmuller, and Andreas Wodarz
J. Cell Sci. published 29 September 2009, 10.1242/jcs.052514 [Abstract] [PDF]

Mechanoregulation of BK channel activity in the mammalian cortical collecting duct: role of protein kinases A and C
Wen Liu, Yuan Wei, Peng Sun, Wen-Hui Wang, Thomas R. Kleyman, and Lisa M. Satlin
Am J Physiol Renal Physiol. 2009; 297:F904-F915. [Abstract]

Mutation of protein kinase C{alpha} phosphorylation site S1076 on -subunits affects BKCa channel activity in HEK-293 cells
Shu Zhu, Darren D. Browning, Richard E. White, David Fulton, and Scott A. Barman
Am J Physiol Lung Cell Mol Physiol. 2009; 297:L758-L766. [Abstract]

PKC{alpha} {beta} {gamma}- and PKC{delta}-dependent endocytosis of NBCe1-A and NBCe1-B in salivary parotid acinar cells
Irina Grichtchenko, Clint Perry, Olga Baker, and Mary Reyland
Am J Physiol Cell Physiol. published 25 September 2009, 10.1152/ajpcell.00028.2009 [Abstract]

GPD1L links redox state to cardiac excitability by PKC-dependent phosphorylation of the sodium channel SCN5A
Carmen R. Valdivia, Kazuo Ueda, Michael J. Ackerman, and Jonathan C. Makielski
Am J Physiol Heart Circ Physiol. 2009; 297:H1446-H1452. [Abstract]

Increased Expression of Gelatinase (MMP-2 and MMP-9) in Pterygia and Pterygium Fibroblasts with Disease Progression and Activation of Protein Kinase C
Shun-Fa Yang, Ching-Yang Lin, Pei-Yu Yang, Shih-Chun Chao, Yi-Zhen Ye, and Dan-Ning Hu
Invest. Ophthalmol. Vis. Sci. 2009; 50:4588-4596. [Abstract] [Full Text] [PDF]

Interleukin-25 expressed by brain capillary endothelial cells maintains blood-brain barrier function in a protein kinase C{epsilon}-dependent manner
Yoshifumi Sonobe, Hideyuki Takeuchi, Kunio Kataoka, Hua Li, Shijie Jin, Maya Mimuro, Yoshio Hashizume, Yasuteru Sano, Takashi Kanda, Tetsuya Mizuno, and Akio Suzumura
J. Biol. Chem. published 23 September 2009, 10.1074/jbc.M109.025940 [Abstract] [PDF]

Epidermal Growth Factor Receptor Variant III?Induced Glioma Invasion Is Mediated through Myristoylated Alanine-Rich Protein Kinase C Substrate Overexpression
Johann Micallef, Michael Taccone, Joydeep Mukherjee, Sidney Croul, Jennifer Busby, Michael F. Moran, and Abhijit Guha
Cancer Res. published 22 September 2009, 10.1158/0008-5472.CAN-08-4783 [Abstract]

Translational Control of Protein Kinase C{eta} by Two Upstream Open Reading Frames (uORFs)
Hadas Raveh-Amit, Adva Maissel, Jonathan Poller, Liraz Marom, Orna Elroy-Stein, Michal Shapira, and Etta Livneh
Mol. Cell. Biol. published 21 September 2009, 10.1128/MCB.01044-09 [Abstract] [PDF]

Hyaluronan-CD44 Interaction with Protein Kinase C{epsilon} Promotes Oncogenic Signaling by the Stem Cell Marker Nanog and the Production of MicroRNA-21, Leading to Down-regulation of the Tumor Suppressor Protein PDCD4, Anti-apoptosis, and Chemotherapy Resistance in Breast Tumor Cells
Lilly Y. W. Bourguignon, Christina C. Spevak, Gabriel Wong, Weiliang Xia, and Eli Gilad
J. Biol. Chem. 2009; 284:26533-26546. [Abstract]

Phosphorylation of Histone H3 by Protein Kinase C Signaling Plays a Critical Role in the Regulation of the Developmentally Important TBX2 Gene
Huajian Teng, Reyna Deeya Ballim, Shaheen Mowla, and Sharon Prince
J. Biol. Chem. 2009; 284:26368-26376. [Abstract]

Neurotrophins Induce Neuregulin Release through Protein Kinase C{delta} Activation
Raymond M. Esper and Jeffrey A. Loeb
J. Biol. Chem. 2009; 284:26251-26260. [Abstract]

A biologically active sequence of the laminin{alpha}2 LG1 domain promotes cell adhesion through syndecan-1 by inducing phosphorylation and membrane localization of the PKC{delta}
Sung Youn Jung, Jin-Man Kim, Hyun Ki Kang, Da Hyun Jang, and Byung-Moo Min
J. Biol. Chem. published 17 September 2009, 10.1074/jbc.M109.038547 [Abstract] [PDF]

Protein Kinase C-Inhibiting Properties of the Losartan Metabolite EXP3179 Make the Difference
Philip Wenzel, Eberhard Schulz, and Thomas Munzel
Hypertension. 2009; 54:707-709. [Extract] [Full Text] [PDF]

Losartan Metabolite EXP3179 Blocks NADPH Oxidase-Mediated Superoxide Production by Inhibiting Protein Kinase C: Potential Clinical Implications in Hypertension
Ana Fortuno, Julen Bidegain, Pablo A. Robador, Jose Hermida, Jacinto Lopez-Sagaseta, Oscar Beloqui, Javier Diez, and Guillermo Zalba
Hypertension. 2009; 54:744-750. [Abstract] [Full Text] [PDF]

Thrombin Induces EGF Receptor Expression and Cell Proliferation via a PKC({delta})/c-Src-Dependent Pathway in Vascular Smooth Muscle Cells
Hsi-Lung Hsieh, Wei-Hsuan Tung, Cheng-Ying Wu, Hui-Hsin Wang, Chih-Chung Lin, Tze-Shyuan Wang, and Chuen-Mao Yang
Arterioscler Thromb Vasc Biol. 2009; 29:1594-1601. [Abstract] [Full Text] [PDF]

Neuronal Thy-1 induces astrocyte adhesion by engaging syndecan-4 in a cooperative interaction with {alpha}v{beta}3 integrin that activates PKC{alpha} and RhoA
Ana Maria Avalos, Alejandra D. Valdivia, Nicolas Munoz, Rodrigo Herrera-Molina, Julio C. Tapia, Sergio Lavandero, Mario Chiong, Keith Burridge,Pascal Schneider, Andrew F. G. Quest, and Lisette Leyton
J. Cell Sci. 2009; 122:3462-3471. [Abstract] [Full Text] [PDF]

TPA inhibits melanoma growth by inactivation of STAT3 through PKC-activated tyrosine phosphatase(s)
Masahiro Oka, Naoko Sumita, Masanori Sakaguchi, Tetsushi Iwasaki, Toshinori Bito, Toshiro Kageshita, Ken-ichi Sato, Yasuo Fukami, and Chikako Nishigori
J. Biol. Chem. published 15 September 2009, 10.1074/jbc.M109.001073 [Abstract] [PDF]

Phosphorylation of Zona Occludens-2 by Protein Kinase C{epsilon} Regulates Its Nuclear Exportation
David Chamorro, Lourdes Alarcon, Arturo Ponce, Rocio Tapia, Hector Gonzalez-Aguilar, Martha Robles-Flores, Teresa Mejia-Castillo, Jose Segovia, Yamir Bandala, Eusebio Juaristi, and Lorenza Gonzalez-Mariscal
Mol. Biol. Cell. 2009; 20:4120-4129. [Abstract] [Full Text] [PDF]

Peripheral Nociception Associated With Surgical Incision Elicits Remote Nonischemic Cardioprotection Via Neurogenic Activation of Protein Kinase C Signaling
W. Keith Jones, Guo-Chang Fan, Siyun Liao, Jun-Ming Zhang, Yang Wang, Neal L. Weintraub, Evangelia G. Kranias, Jo El Schultz, John Lorenz, and Xiaoping Ren
Circulation. 2009; 120:S1-S9. [Abstract] [Full Text] [PDF]

Protein kinase C{gamma}, a protein causative for dominant ataxia, negatively regulates nuclear import of recessive-ataxia-related aprataxin
Hirohide Asai, Makito Hirano, Keiji Shimada, Takao Kiriyama, Yoshiko Furiya, Masanori Ikeda, Takaaki Iwamoto, Toshio Mori, Kazuto Nishinaka, Noboru Konishi, Fukashi Udaka, and Satoshi Ueno
Hum. Mol. Genet. 2009; 18:3533-3543. [Abstract] [Full Text] [PDF]

Protein Kinase C{delta}- Transactivates Platelet-derived Growth Factor Receptor{alpha}- in Mechanical Strain-induced Collagenase 3 (Matrix Metalloproteinase-13) Expression by Osteoblast-like Cells
Chuen-Mao Yang, Hsi-Lung Hsieh, Chung-Chen Yao, Li-Der Hsiao, Chin-Ping Tseng, and Chou Bing Wu
J. Biol. Chem. 2009; 284:26040-26050. [Abstract]

Inhibition of protein kinase C signaling protects prefrontal cortex dendritic spines and cognition from the effects of chronic stress
Avis Brennan Hains, Mai Anh T. Vu, Paul K. Maciejewski, Christopher H. van Dyck, Melissa Gottron, and Amy F. T. Arnsten
PNAS. published 11 September 2009, 10.1073/pnas.0908563106 [Abstract] [PDF]

Maturation and the role of PKC-mediated contractility in ovine cerebral arteries
Ravi Goyal, Ashwani Mittal, Nina Chu, Lijun Shi, Lubo Zhang, and Lawrence D. Longo
Am J Physiol Heart Circ Physiol. published 11 September 2009, 10.1152/ajpheart.00681.2009 [Abstract]

PKC-dependent superoxide production by the renal medullary thick ascending limb from diabetic rats
Jing Yang, Pascale H Lane, Jennifer S. Pollock, and Pamela K. Carmines
Am J Physiol Renal Physiol. published 9 September 2009, 10.1152/ajprenal.00314.2009 [Abstract]

Identification of novel cell wall destabilizing antifungal compounds using a conditional Aspergillus nidulans protein kinase C mutant
Gabriel Mircus, Shelly Hagag, Emma Levdansky, Haim Sharon, Yona Shadkchan, Itamar Shalit, and Nir Osherov
J. Antimicrob. Chemother. 2009; 64:755-763. [Abstract] [Full Text] [PDF]

BMS-214662 induces mitochondrial apoptosis in CML stem/progenitor cells, including CD34+38- cells, through activation of protein kinase C{beta}
Francesca Pellicano, Mhairi Copland, Heather G. Jorgensen, Joanne Mountford, Brian Leber, and Tessa L. Holyoake
Blood. published 8 September 2009, 10.1182/blood-2009-05-219550 [Abstract] [PDF]

No Specific Subcellular Localization of Protein Kinase C Is Required for Cytotoxic T Cell Granule Exocytosis
Arun T. Pores-Fernando, Michelle Y. D. Ranaghan, and Adam Zweifach
J. Biol. Chem. 2009; 284:25107-25115. [Abstract]

Regulation of intracerebral arteriolar tone by Kv channels: effects of glucose and PKC
Stephen V. Straub, Helene Girouard, Paul E. Doetsch, Rachael M. Hannah, M. Keith Wilkerson, and Mark T. Nelson
Am J Physiol Cell Physiol. 2009; 297:C788-C796. [Abstract]

Regulation of the Benzamil-Insensitive Salt Taste Receptor by Intracellular Ca2+, Protein Kinase C, and Calcineurin
Vijay Lyall, Tam-Hao T. Phan, Shobha Mummalaneni, Pamela Melone, Sunila Mahavadi, Karnam S. Murthy, and John A. DeSimone
J Neurophysiol. 2009; 102:1591-1605. [Abstract]

Negation of the cancer-preventive actions of selenium by over-expression of protein kinase C{epsilon} and selenoprotein thioredoxin reductase
Usha Gundimeda, Jason Eric Schiffman, Simcha Neeli Gottlieb, Brandon Ian Roth, and Rayudu Gopalakrishna
Carcinogenesis. 2009; 30:1553-1561. [Abstract] [Full Text] [PDF]