July 2009

July 2009

Protein Kinase C{alpha}, but Not PKC{beta} or PKC{gamma}, Regulates Contractility and Heart Failure Susceptibility. Implications for Ruboxistaurin As a Novel Therapeutic Approach.
Qinghang Liu, Xiongwen Chen, Scott M Macdonnell, Evangelia G Kranias, John N Lorenz, Michael Leitges, Steven R Houser, and Jeffery D Molkentin
Circ Res. 2009. [MEDLINE Citation]

PKC-theta modulates the strength of T cell responses by targeting Cbl-b for ubiquitination and degradation.
T Gruber, N Hermann-Kleiter, R Hinterleitner, F Fresser, R Schneider, G Gastl, JM Penninger, and G Baier
Sci Signal. 2009; 2: ra30. [MEDLINE Citation]

Phosphorylation of endothelial nitric oxide synthase by atypical PKC{zeta} contributes to angiopoietin-1-dependent inhibition of VEGF-induced endothelial permeability in vitro.
Malika Oubaha and Jean-Philippe Gratton
Blood. 2009. [MEDLINE Citation]

Preclinical Development of a Bifunctional Cancer Cell Homing, PKC{varepsilon} Inhibitory Peptide for the Treatment of Head and Neck Cancer.
Liwei Bao, Michael A Gorin, Manchao Zhang, Alejandra C Ventura, William C Pomerantz, Sofia D Merajver, Theodoros N Teknos, Anna K Mapp, and Quintin Pan
Cancer Res. 2009. [MEDLINE Citation]

Involvement of the ornithine decarboxylase/polyamine system in precondition-induced cardioprotection through an interaction with PKC in rat hearts.
Ya-Jun Zhao, Wei-Hua Zhang, Chang-Qing Xu, Hong-Zhu Li, Li-Na Wang, Hong Li, Yi-Hua Sun, Yan Lin, Li-Ping Han, Li Zhang, Yie Tian, Rui Wang, Bao-Feng Yang, and Wei-Min Li
Mol Cell Biochem. 2009. [MEDLINE Citation]

Morphine withdrawal regulates phosphorylation of cAMP response element binding protein (CREB) through PKC in the nucleus tractus solitarius-A catecholaminergic neurons.
Fatima Martin, M Luisa Laorden, and M Victoria Milanes
J Neurochem. 2009. [MEDLINE Citation]

Oxidized Low-Density Lipoprotein-Induced Matrix Metalloproteinase-9 Expression via PKC-delta/p42/p44 MAPK/Elk-1 Cascade in Brain Astrocytes.
Hui-Hsin Wang, Hsi-Lung Hsieh, Cheng-Ying Wu, and Chuen-Mao Yang
Neurotox Res. 2009. [MEDLINE Citation]

PKC delta mediates Nrf2-dependent protection of neuronal cells from NO-induced apoptosis.
Jindan Zhang, Amos C Hung, Poh Yong Ng, Keiichi Nakayama, Yuanyu Hu, Baojie Li, Alan G Porter, and Saravanakumar Dhakshinamoorthy
Biochem Biophys Res Commun. 2009. [MEDLINE Citation]

Rescue of atypical protein kinase C in epithelia by the cytoskeleton and Hsp70 family chaperones.
Anastasia Mashukova, Andrea S Oriolo, Flavia A Wald, M Llanos Casanova, Cornelia Kroger, Thomas M Magin, M Bishr Omary, and Pedro J I Salas
J Cell Sci. 2009. [MEDLINE Citation]

A 20-Amino Acid Module of Protein Kinase C ${epsilon}$ Involved in Translocation and Selective Targeting at Cell-Cell Contacts
Barthélémy Diouf, Alejandra Collazos, Gilles Labesse, Françoise Macari, Armelle Choquet, Philippe Clair, Cécile Gauthier-Rouvière, Nathalie C. Guérineau, Philippe Jay, Frédéric Hollande, and Dominique Joubert
J. Biol. Chem. 2009; 284:18808-18815. [Abstract] [Full Text] [PDF]

Negation of the cancer-preventive actions of selenium by overexpression of protein kinase C ${epsilon}$ and selenoprotein thioredoxin reductase
Usha Gundimeda, Jason Eric Schiffman, Simcha Neeli Gottlieb, Brandon Roth, and Rayudu Gopalakrishna
Carcinogenesis. published 3 July 2009, 10.1093/carcin/bgp164 [Abstract] [PDF]

Atypical PKC: keratin to the rescue
J. Cell Sci. 2009; 122:e1403. [Full Text] [PDF]

Rescue of atypical protein kinase C in epithelia by the cytoskeleton and Hsp70 family chaperones
Anastasia Mashukova, Andrea S. Oriolo, Flavia A. Wald, M. Llanos Casanova, Cornelia Kröger, Thomas M. Magin, M. Bishr Omary, and Pedro J. I. Salas
J. Cell Sci. 2009; 122:2491-2503. [Abstract] [Full Text] [PDF]

An adhesion-independent, aPKC-dependent function for cadherins in morphogenetic movements
Karla Seifert, Hady Ibrahim, Torben Stodtmeister, Rudolf Winklbauer, and Carien M. Niessen
J. Cell Sci. 2009; 122:2514-2523. [Abstract] [Full Text] [PDF]

Modulation of Ileal Apical Sodium-Dependent Bile Acid Transporter ASBT by Protein Kinase C
Zaheer Sarwar, Fadi Annaba, Alka Dwivedi, Seema Saksena, Ravinder K. Gill, and Waddah A. Alrefai
Am J Physiol Gastrointest Liver Physiol. published 1 July 2009, 10.1152/ajpgi.00052.2009 [Abstract] [PDF]

Kalopanaxsaponin A inhibits PMA-induced invasion by reducing matrix metalloproteinase-9 via PI3K/Akt- and PKC ${delta}$ -mediated signaling in MCF-7 human breast cancer cells
Sun Kyu Park, Young Sun Hwang, Kwang-Kyun Park, Hee-Juhn Park, Jeong Yeon Seo, and Won-Yoon Chung
Carcinogenesis. 2009; 30:1225-1233. [Abstract] [Full Text] [PDF]

PKC ${varepsilon}$ Regulation of an ${alpha}$ ₅ Integrin–ZO-1 Complex Controls Lamellae Formation in Migrating Cancer Cells
Saara Tuomi, Anja Mai, Jonna Nevo, Jukka O. Laine, Vesa Vilkki, Tiina J. Öhman, Carl G. Gahmberg, Peter J. Parker, and Johanna Ivaska
Sci. Signal. 2009; 2:ra32. [Abstract] [Summary] [Full Text] [PDF]

Preclinical Development of a Bifunctional Cancer Cell Homing, PKC ${varepsilon}$ Inhibitory Peptide for the Treatment of Head and Neck Cancer
Liwei Bao, Michael A. Gorin, Manchao Zhang, Alejandra C. Ventura, William C. Pomerantz, Sofia D. Merajver, Theodoros N. Teknos, Anna K. Mapp, and Quintin Pan
Cancer Res. published 30 June 2009, 10.1158/0008-5472.CAN-08-3465 [Abstract]

Cortical F-Actin, the Exocytic Mode, and Neuropeptide Release in Mouse Chromaffin Cells Is Regulated by Myristoylated Alanine-rich C-Kinase Substrate and Myosin II
Bryan W. Doreian, Tiberiu G. Fulop, Robert L. Meklemburg, and Corey B. Smith
Mol. Biol. Cell. 2009; 20:3142-3154. [Abstract] [Full Text] [PDF]

Protein Kinase Cgamma Mediates Regulation of Proliferation by the Serotonin 5-Hydroxytryptamine Receptor 2B
Mira M. Wouters, Jaime L. Roeder, Vivek S. Tharayil, Jennifer E. Stanich, Peter R. Strege, Sha Lei, Michael R. Bardsley, Tamas Ordog, Simon J. Gibbons, and Gianrico Farrugia
J. Biol. Chem. 2009; 284:21177-21184. [Abstract] [Full Text] [PDF]

Inhibition of Protein Kinase C Is not Sufficient to Prevent or Revert Effects of VEGF165 on Tight Junction Protein Claudin-1 and Permeability in Microvascular Retinal Endothelial Cells
Heidrun L Deissler, Helmut Deissler, and Gabriele E. Lang
Invest. Ophthalmol. Vis. Sci. published 30 July 2009, 10.1167/iovs.09-3917 [Abstract] [PDF]

Phosphorylation Status of Nuclear Ribosomal Protein S3 Is Reciprocally Regulated by Protein Kinase C delta and Protein Phosphatase 2A
Tae-Sung Kim, Hag Dong Kim, Hyun-Seock Shin, and Joon Kim
J. Biol. Chem. 2009; 284:21201-21208. [Abstract] [Full Text] [PDF]

Deletion of PKCε Selectively Enhances the Amplifying Pathways of Glucose-Stimulated Insulin Secretion via Increased Lipolysis in Mouse β-Cells
James Cantley, James G. Burchfield, Gemma L. Pearson, Carsten Schmitz-Peiffer, Michael Leitges, and Trevor J. Biden
Diabetes. 2009; 58:1826-1834. [Abstract] [Full Text] [PDF]

Adenoprotection of the heart involves phospholipase C-induced activation and translocation of PKCε to RACK2 in adult rat and mouse
Richard A. Fenton, Satoshi Komatsu, Mitsuo Ikebe, Lynne G. Shea, and James G. Dobson, Jr.
Am J Physiol Heart Circ Physiol. 2009; 297:H718-H725. [Abstract]

Galectin-1 co-clusters CD43/CD45 on dendritic cells and induces cell activation and migration through Syk and PKC signaling
Jennifer A. Fulcher, Margaret H. Chang, Shuo Wang, Tim Almazan, Sara T. Hashimi, Anna U. Eriksson, Xiangshu Wen, Mabel Pang, Linda G. Baum,
Ram Raj Singh, and Benhur Lee
J. Biol. Chem. published 27 July 2009, 10.1074/jbc.M109.037507 [Abstract] [PDF]

Sequential Activation of Protein Kinase C Isoforms by Organic Dust is Mediated by Tumor Necrosis Factor
Todd A Wyatt, Rebecca E Slager, Arthur J Heires, Jane M DeVasure, Susanna G Von Essen, Jill A Poole, and Debra J Romberger
Am. J. Respir. Cell Mol. Biol. published 27 July 2009, 10.1165/rcmb.2009-0065OC [Abstract] [PDF]

Phosphorylation of histone H3 by PKC signalling plays a critical role in the regulation of the developmentally important TBX2 gene
Huajian Teng, Reyna Deeya Ballim, Shaheen Mowla, and Sharon Prince
J. Biol. Chem. published 24 July 2009, 10.1074/jbc.M109.021360 [Abstract] [PDF]

PKCdelta transactivates PDGFRalpha in mechanical strain induced collagenase 3 (MMP-13) expression by osteoblast-like cells
Chuen-Mao Yang, Hsi-Lung Hsieh, Chung-Chen Yao, Li-Der Hsiao, Chin-Ping Tseng, and Chou Bing Wu
J. Biol. Chem. published 24 July 2009, 10.1074/jbc.M109.040154 [Abstract] [PDF]

Phosphorylation of Zona Occludens-2 by Protein Kinase C varepsilon Regulates Its Nuclear Exportation
David Chamorro, Lourdes Alarcon, Arturo Ponce, Rocio Tapia, Hector Gonzalez-Aguilar, Martha Robles-Flores, Teresa Mejia-Castillo, Jose Segovia, Yamir Bandala, Eusebio Juaristi, and Lorenza Gonzalez-Mariscal
Mol. Biol. Cell. published 22 July 2009, 10.1091/mbc.E08-11-1129 [Abstract] [PDF]

Knockout of the predominant conventional PKC isoform, PKCalpha, in mouse skeletal muscle does not affect contraction-stimulated glucose uptake
Thomas E. Jensen, Stine J. Maarbjerg, Adam J. Rose, Michael Leitges, and Erik A. Richter
Am J Physiol Endocrinol Metab. 2009; 297:E340-E348. [Abstract]

Activation of Intracellular Signaling Pathways by the Murine Cytomegalovirus G Protein-Coupled Receptor M33 Occurs via PLC-β/PKC-Dependent and -Independent Mechanisms
Joseph D. Sherrill, Melissa P. Stropes, Olivia D. Schneider, Diana E. Koch, Fabiola M. Bittencourt, Jeanette L. C. Miller, and William E. Miller (15 August 2009)
J. Virol. 83 (16), 8141. [DOI: 10.1128/JVI.02116-08] [Abstract] [PDF]

Crystal-Induced Neutrophil Activation: XI. Implication and Novel Roles of Classical Protein Kinase C
Oana Popa-Nita, Sophie Proulx, Guillaume Pare, Emmanuelle Rollet-Labelle, and Paul H. Naccache
J. Immunol. 2009; 183:2104-2114. [Abstract] [Full Text] [PDF]

Phorbol 12-Myristate 13-Acetate Potentiation of N-Methyl-D-aspartate-Induced Currents in Primary Cultured Cerebellar Granule Cells Is Mediated by Protein Kinase C alpha
Jason C. Reneau, Mary E. Reyland, Jonathan Phillips, Carissa Kindy, and R. Lisa Popp
J. Pharmacol. Exp. Ther. 2009; 330:641-649. [Abstract] [Full Text] [PDF]

Prenatal Hypoxia Causes a Sex-Dependent Increase in Heart Susceptibility to Ischemia and Reperfusion Injury in Adult Male Offspring: Role of Protein Kinase C epsilon.
Qin Xue and Lubo Zhang
J. Pharmacol. Exp. Ther. 2009; 330:624-632. [Abstract] [Full Text] [PDF]

Protein Kinase C alpha, but Not PKC beta or PKC gamma, Regulates Contractility and Heart Failure Susceptibility: Implications for Ruboxistaurin as a Novel Therapeutic Approach
Qinghang Liu, Xiongwen Chen, Scott M. MacDonnell, Evangelia G. Kranias, John N. Lorenz, Michael Leitges, Steven R. Houser, and Jeffery D. Molkentin
Circ. Res. 2009; 105:194-200. [Abstract] [Full Text] [PDF]

Protein Kinase C delta Activates RelA/p65 and Nuclear Factor-B kappa Signaling in Response to Tumor Necrosis Factor-kappa
Zheng-Guang Lu, Hanshao Liu, Tomoko Yamaguchi, Yoshio Miki, and Kiyotsugu Yoshida
Cancer Res. 2009; 69:5927-5935. [Abstract]

Endothelin-I and angiotensin II inhibit arterial voltage-gated K+ channels through different protein kinase C isoenzymes
Richard D. Rainbow, Robert I. Norman, Diane E. Everitt, Jennifer L. Brignell, Noel W. Davies, and Nicholas B. Standen
Cardiovasc Res. 2009; 83:493-500. [Abstract] [Full Text] [PDF]

MATER protein as substrate of PKC epsilon in human cumulus cells
T. Maraldi, M. Riccio, P. Sena, L. Marzona, A. Nicoli, A. La Marca, S. Marmiroli, J. Bertacchini, G. La Sala, and A. De Pol
Mol. Hum. Reprod. 2009; 15:499-506. [Abstract] [Full Text] [PDF]

Suppression of RhoG activity is mediated by a syndecan 4?synectin?RhoGDI1 complex and is reversed by PKC alpha in a Rac1 activation pathway
Arye Elfenbein, John M. Rhodes, Julia Meller, Martin A. Schwartz, Michiyuki Matsuda, and Michael Simons
J. Cell Biol. 2009; 186:75-83. [Abstract] [Full Text] [PDF]

Sprouty2 Interacts with Protein Kinase C delta and Disrupts Phosphorylation of Protein Kinase D1
Soah Yee Chow, Chye Yun Yu, and Graeme R. Guy
J. Biol. Chem. 2009; 284:19623-19636. [Abstract]

Mutation of Protein Kinase C alpha Phosphorylation Site S1076 on -Subunits Affects BKCa Channel Activity in HEK293 Cells
Shu Zhu, Darren D. Browning, Richard E. White, David J.R. Fulton, and Scott A. Barman
Am J Physiol Lung Cell Mol Physiol. published 10 July 2009, 10.1152/ajplung.90518.2008 [Abstract]

A1 adenosine receptor-mediated protein kinase C and p42/p44 mitogen-activated protein kinase signaling in mouse coronary artery smooth muscle cells
Habib R. Ansari, Bunyen Teng, Ahmed Nadeem, Kevin P Roush, Karen H Martin, Jurgen B Schnermann, and S. Jamal Mustafa
Am J Physiol Heart Circ Physiol. published 10 July 2009, 10.1152/ajpheart.00374.2009 [Abstract]

No specific subcellular localization of protein kinase C is required for cytotoxic T cell granule exocytosis
Arun T. Pores-Fernando, Michelle Y. D. Ranaghan, and Adam Zweifach
J. Biol. Chem. published 10 July 2009, 10.1074/jbc.M109.011866 [Abstract] [PDF]

PKC theta in platelet activation
Matthew T. Harper and Alastair W. Poole
Blood. 2009; 114:489-491. [Full Text] [PDF]

Response:Role of PKC in collagen-related peptide-induced platelet activation
Satya P. Kunapuli and Jianguo Jin
Blood. 2009; 114:491-492. [Full Text] [PDF]

Selective Inhibition of Protein Kinase C β2 Attenuates Inducible Nitric Oxide Synthase Mediated Cardiovascular Abnormalities in Streptozotocin -Diabetic Rats
Prabhakara Reddy Nagareddy, Hesham Soliman, Guorong Lin, Padmesh S Rajput, Ujendra Kumar, John H. McNeill, and Kathleen M. MacLeod
Diabetes. published 8 July 2009, 10.2337/db09-0432 [Abstract]

Protein Kinase C delta Plays a Key Role in Cellular Senescence Programs of Human Normal Diploid Cells
Yoshinori Katakura, Miyako Udono, Kazuyuki Katsuki, Hisaya Nishide, Yukiko Tabira, Takahiro Ikei, Makiko Yamashita, Tsukasa Fujiki, and Sanetaka Shirahata
J. Biochem. 2009; 146:87-93. [Abstract] [Full Text] [PDF]

Physical and Functional Interaction Between Calcineurin and the Cardiac L-Type Ca2+ Channel
Samvit Tandan, Yanggan Wang, Thomas T. Wang, Nan Jiang, Duane D. Hall, Johannes W. Hell, Xiang Luo, Beverly A. Rothermel, and Joseph A. Hill
Circ. Res. 2009; 105:51-60. [Abstract] [Full Text] [PDF]