June 2009

Relaxin alters cardiac myofilament function through a PKC-dependent pathway
Erynn E. Shaw, Philip Wood, Justyna Kulpa, Feng Hua Yang, Alastair J. Summerlee, and W. Glen Pyle
Am J Physiol Heart Circ Physiol. 2009; 297:H29-H36.  [Abstract] [Full Text] [PDF]

Periadventitial adipose tissue impairs coronary endothelial function via PKC-モ-dependent phosphorylation of nitric oxide synthase
Gregory A. Payne, H. Glenn Bohlen, Ü. Deniz Dincer, Léna Borbouse, and Johnathan D. Tune
Am J Physiol Heart Circ Physiol. 2009; 297:H460-H465.  [Abstract] [Full Text] [PDF]

Phosphorylation of endothelial nitric oxide synthase by atypical PKC{zeta} contributes to angiopoietin-1-dependent inhibition of VEGF-induced endothelial permeability in vitro
Malika Oubaha and Jean-Philippe Gratton
Blood. published 29 June 2009, 10.1182/blood-2008-12-196584  [Abstract] [PDF]

Protein kinase C{gamma}, a protein causative for dominant ataxia, negatively regulates nuclear import of recessive-ataxia-related aprataxin
Hirohide Asai, Makito Hirano, Keiji Shimada, Takao Kiriyama, Yoshiko Furiya, Masanori Ikeda, Takaaki Iwamoto, Toshio Mori, Kazuto Nishinaka, Noboru Konishi, Fukashi Udaka, and Satoshi Ueno
Hum. Mol. Genet. published 26 June 2009, 10.1093/hmg/ddp298  [Abstract] [PDF]

Serine proteases decrease intestinal epithelial ion permeability by activation of protein kinase C{zeta}
Veronica A. Swystun, Bernard Renaux, France Moreau, Shoubin Wen, Michael A. Peplowski, Morley D. Hollenberg, and Wallace K. MacNaughton
Am J Physiol Gastrointest Liver Physiol. 2009; 297:G60-G70.  [Abstract] [Full Text] [PDF]

GnRH Stimulates Expression of PACAP in the Pituitary Gonadotropes via Both the PKA and PKC Signaling Systems
Constance M. Grafer, Robin Thomas, Litsa Lambrakos, Ignacio Montoya, Sheryl White, and Lisa M. Halvorson
Mol. Endocrinol. 2009; 23:1022-1032.  [Abstract] [Full Text] [PDF]

Protein Kinase C{alpha}, but Not PKC{beta} or PKC{gamma}, Regulates Contractility and Heart Failure Susceptibility. Implications for Ruboxistaurin As a Novel Therapeutic Approach
Qinghang Liu, Xiongwen Chen, Scott M. MacDonnell, Evangelia G. Kranias, John N. Lorenz, Michael Leitges, Steven R. Houser, and Jeffery D. Molkentin
Circ. Res. published 25 June 2009, 10.1161/CIRCRESAHA.109.195313  [Abstract] [PDF]

Excretory-secretory products from Paragonimus westermani increase nitric oxide production in microglia in PKC-dependent and -independent manners.
Youngnam Jin, In Young Choi, Chunsook Kim, Suyoung Hong, and Won-Ki Kim
Neurosci Res. 2009. [MEDLINE Citation]

Protein kinase Cgamma mediates regulation of proliferation by the serotonin 5-HT2B receptor.
Mira M Wouters, Jaime L Roeder, Vivek S Tharayil, Jennifer E Stanich, Peter R Strege, Sha Lei, Michael R Bardsley, Tamas Ordog, Simon J Gibbons, and Gianrico Farrugia
J Biol Chem. 2009. [MEDLINE Citation]

Role of protein kinase C delta in angiotensin II induced cardiac fibrosis.
Vishnu Chintalgattu and Laxmansa C Katwa
Biochem Biophys Res Commun. 2009. [MEDLINE Citation]

Mechanisms of Protein Kinase C Signaling in the Modulation of 3',5'-Cyclic Adenosine Monophosphate-Mediated Steroidogenesis in Mouse Gonadal Cells
Pulak R. Manna, Ilpo T. Huhtaniemi, and Douglas M. Stocco
Endocrinology. 2009; 150:3308-3317.  [Abstract] [Full Text] [PDF]

Protein Kinase C{delta} Activates RelA/p65 and Nuclear Factor-{kappa}B Signaling in Response to Tumor Necrosis Factor-{alpha}
Zheng-Guang Lu, Hanshao Liu, Tomoko Yamaguchi, Yoshio Miki, and Kiyotsugu Yoshida
Cancer Res. published 23 June 2009, 10.1158/0008-5472.CAN-08-4786  [Abstract]

Etoposide Induces Protein Kinase C {delta}- and Caspase-3-dependent Apoptosis in Neuroblastoma Cancer Cells
Travis W. Day, Ching-Huang Wu, and Ahmad R. Safa
Mol. Pharmacol. published 23 June 2009, 10.1124/mol.109.054999  [Abstract] [PDF]

PKC-{theta} Modulates the Strength of T Cell Responses by Targeting Cbl-b for Ubiquitination and Degradation
Sci. Signal., Vol. 2, Issue 76, pp. ra30 [Summary] [Abstract] [Full Text

Rescue of atypical protein kinase C in epithelia by the cytoskeleton and Hsp70 family chaperones
Anastasia Mashukova, Andrea S. Oriolo, Flavia A. Wald, M. Llanos Casanova, Cornelia Kröger, Thomas M. Magin, M. Bishr Omary, and Pedro J.I. Salas
J. Cell Sci. published 23 June 2009, 10.1242/jcs.046979  [Abstract] [PDF]

An adhesion-independent, aPKC-dependent function for cadherins in morphogenetic movements
Karla Seifert, Hady Ibrahim, Torben Stodtmeister, Rudolf Winklbauer, and Carien M. Niessen
J. Cell Sci. published 23 June 2009, 10.1242/jcs.042796  [Abstract] [PDF]

Activation of Protein Kinase C{alpha} by EPAC1 Is Required for the ERK- and CCAAT/Enhancer-binding Protein モ-dependent Induction of the SOCS-3 Gene by Cyclic AMP in COS1 Cells
Gillian Borland, Rebecca J. Bird, Timothy M. Palmer, and Stephen J. Yarwood
J. Biol. Chem. 2009; 284:17391-17403.  [Abstract] [Full Text] [PDF]

Phosphorylation of {alpha}6-Tubulin by Protein Kinase C{alpha} Activates Motility of Human Breast Cells
Thushara P. Abeyweera, Xiangyu Chen, and Susan A. Rotenberg
J. Biol. Chem. 2009; 284:17648-17656.  [Abstract] [Full Text] [PDF]

Activation of Protein Kinase C{alpha} by EPAC1 Is Required for the ERK- and CCAAT/Enhancer-binding Protein モ-dependent Induction of the SOCS-3 Gene by Cyclic AMP in COS1 Cells
Gillian Borland, Rebecca J. Bird, Timothy M. Palmer, and Stephen J. Yarwood
J. Biol. Chem. 2009; 284:17391-17403.  [Abstract] [Full Text] [PDF]

Phosphorylation of {alpha}6-Tubulin by Protein Kinase C{alpha} Activates Motility of Human Breast Cells
Thushara P. Abeyweera, Xiangyu Chen, and Susan A. Rotenberg
J. Biol. Chem. 2009; 284:17648-17656.  [Abstract] [Full Text] [PDF]

Correlation between Apical Localization of Abcc2/Mrp2 and Phosphorylation Status of Ezrin in Rat Intestine
Takafumi Nakano, Shuichi Sekine, Kousei Ito, and Toshiharu Horie
Drug Metab. Dispos. 2009; 37:1521-1527.  [Abstract] [Full Text] [PDF]

Transforming Growth Factor-モ Promotes Recruitment of Bone Marrow Cells and Bone Marrow-derived Mesenchymal Stem Cells through Stimulation of MCP-1 Production in Vascular Smooth Muscle Cells
Fan Zhang, Shirling Tsai, Kaori Kato, Dai Yamanouchi, Chunjie Wang, Shahin Rafii, Bo Liu, and K. Craig Kent
J. Biol. Chem. 2009; 284:17564-17574.  [Abstract] [Full Text] [PDF]

Ca2+-independent contraction of longitudinal ileal smooth muscle is potentiated by a zipper-interacting protein kinase pseudosubstrate peptide
Eikichi Ihara, Lori Moffat, Meredith Alison Borman, Jennifer E Amon, Michael P. Walsh, and Justin A. MacDonald
Am J Physiol Gastrointest Liver Physiol. published 18 June 2009, 10.1152/ajpgi.00112.2009  [Abstract] [PDF]

Abscisic Acid Released by Human Monocytes Activates Monocytes and Vascular Smooth Muscle Cell Responses Involved in Atherogenesis
Mirko Magnone, Santina Bruzzone, Lucrezia Guida, Gianluca Damonte, Enrico Millo, Sonia Scarfì, Cesare Usai, Laura Sturla, Domenico Palombo, Antonio De Flora, and Elena Zocchi
J. Biol. Chem. 2009; 284:17808-17818.  [Abstract] [Full Text] [PDF]

The potent protein kinase C selective inhibitor AEB071 (Sotrastaurin)represents a new class of immunosuppressive agents affecting early T cell activation.
Jean-Pierre Evenou, Juergen Wagner, Gerhard Zenke, Volker Brinkmann, Kathrin Wagner, Jiri Kovarik, Karl Welzenbach, Gabriele Weitz-Schmidt, Christine Guntermann, Harry Towbin, Sylvain Cottens, Sandra Kaminski, Thomas Letschka, Christina Lutz-Nicoladoni, Thomas Gruber, Natascha Hermann-Kleiter, Nikolaus Thuille, and Gottfried Baier
J Pharmacol Exp Ther. 2009. [MEDLINE Citation]

Direct Chronic Effect of Steroid Hormones in Attenuating Uterine Arterial Myogenic Tone. Role of Protein Kinase C/Extracellular Signal-Regulated Kinase 1/2.
Daliao Xiao, Xiaohui Huang, Shumei Yang, and Lubo Zhang
Hypertension. 2009. [MEDLINE Citation]

Protein kinase C epsilon activation delays neuronal depolarization during cardiac arrest in the euthermic arctic ground squirrel.
Kunjan R Dave, R Anthony Defazio, Ami P Raval, Oleksandr Dashkin, Isabel Saul, Kimberly E Iceman, Miguel A Perez-Pinzon, and Kelly L Drew
J Neurochem. 2009. [MEDLINE Citation]

Atypical protein kinase C activity is required for extracellular matrix degradation and invasion by Src-transformed cells.
Elena M Rodriguez, Elizabeth E Dunham, and G Steven Martin
J Cell Physiol. 2009. [MEDLINE Citation]

Role of protein kinase C in NADPH oxidase derived O(2)(.-)-mediated regulation of K(V) - LVOCC axis under U46619 induced increase in [Ca(2+)](i) in pulmonary smooth muscle cells.
Sajal Chakraborti, Animesh Chaudhury, Pulak Kar, Partha Das, Soni Shaikh, Soumitra Roy, and Tapati Chakraborti
Arch Biochem Biophys. 2009. [MEDLINE Citation]

Role of protein kinase C in advanced glycation end products-induced epithelial-mesenchymal transition in renal proximal tubular epithelial cells.
S Ge, R Zeng, Y Luo, L Liu, H Wei, J Zhang, H Zhou, and G Xu
J Huazhong Univ Sci Technolog Med Sci. 2009; 29: 281. [MEDLINE Citation]

Design, Synthesis, and Investigation of Protein Kinase C Inhibitors: Total Syntheses of (+)-Calphostin D, (+)-Phleichrome, Cercosporin, and New Photoactive Perylenequinones.
Barbara J Morgan, Sangeeta Dey, Steven W Johnson, and Marisa C Kozlowski
J Am Chem Soc. 2009. [MEDLINE Citation]

Synergistic anti-tumor efficacy of lovastatin and protein kinase C-beta inhibitor in hepatocellular carcinoma.
W Kim, JH Yoon, JR Kim, IJ Jang, YJ Bang, YJ Kim, and HS Lee
Cancer Chemother Pharmacol. 2009; 64: 497. [MEDLINE Citation]

Antiapoptotic effects of vasopressin in the neuronal cell line H32 involve protein kinase C alpha and beta.
Jun Chen, Ying Liu, Jae-Won Soh, and Greti Aguilera
J Neurochem. 2009. [MEDLINE Citation]

Adenoprotection of the Heart Involves Phospholipase C-Induced Activation and Translocation of PKC{varepsilon} to RACK2 in Adult Rat and Mouse.
Richard A Fenton, Satoshi Komatsu, Mitsuo Ikebe, Lynne G Shea, and James G Dobson Jr
Am J Physiol Heart Circ Physiol. 2009. [MEDLINE Citation]

A new mechanism of SOX9 action to regulate PKC{alpha} expression in the intestine epithelium.
Sebastien Dupasquier, Rana Abdel-Samad, Robert I Glazer, Pauline Bastide, Philippe Jay, Dominique Joubert, Vincent Cavailles, Philippe Blache, and Corinne Quittau-Prevostel
J Cell Sci. 2009. [MEDLINE Citation]

Activation of Intracellular Signaling Pathways by the MCMV GPCR M33 Occurs Via PLC-{beta}/PKC Dependent and Independent Mechanisms.
Joseph D Sherrill, Melissa P Stropes, Olivia D Schneider, Diana E Koch, Fabiola M Bittencourt, Jeanette L C Miller, and William E Miller
J Virol. 2009. [MEDLINE Citation]

PKC Delta and Epsilon in Drug Targeting and Therapeutics.
T Yonezawa, R Kurata, M Kimura, and H Inoko
Recent Pat DNA Gene Seq. 2009; 3: 96. [MEDLINE Citation]

PKC isoforms differentially phosphorylate Cav1.2 alpha1c.
Lin Yang, Darshan Doshi, John P Morrow, Alexander Katchman, Xiang Chen, and Steven O Marx
Biochemistry. 2009. [MEDLINE Citation]

DHEA improves impaired activation of Akt and PKC zeta/lambda-GLUT4 pathway in skeletal muscle and improves hyperglycemia in streptozotocin-induced diabetes rats.
Koji Sato, Motoyuki Iemitsu, Katsuji Aizawa, and Ryuichi Ajisaka
Acta Physiol (Oxf). 2009. [MEDLINE Citation]

Phosphorylation of the influenza A virus protein PB1-F2 by PKC is crucial for apoptosis promoting functions in monocytes.
David Mitzner, Sabine Eva Dudek, Nicole Studtrucker, Darisuren Anhlan, Igor Mazur, Josef Wissing, Lothar Jansch, Ludmilla Wixler, Karsten Bruns, Alok Sharma, Victor Wray, Peter Henklein, Stephan Ludwig, and Ulrich Schubert
Cell Microbiol. 2009. [MEDLINE Citation]

Direct Chronic Effect of Steroid Hormones in Attenuating Uterine Arterial Myogenic Tone. Role of Protein Kinase C/Extracellular Signal-Regulated Kinase 1/2.
Daliao Xiao, Xiaohui Huang, Shumei Yang, and Lubo Zhang
Hypertension. 2009. [MEDLINE Citation]

Inhibition of protein kinase C in diabetic nephropathy—where do we stand?
Jan Menne, Matthias Meier, Joon-Keun Park, and Hermann Haller
Nephrol. Dial. Transplant. 2009; 24:2021-2023.  [Extract] [Full Text] [PDF]

Direct Chronic Effect of Steroid Hormones in Attenuating Uterine Arterial Myogenic Tone. Role of Protein Kinase C/Extracellular Signal–Regulated Kinase 1/2
Daliao Xiao, Xiaohui Huang, Shumei Yang, and Lubo Zhang
Hypertension. published 15 June 2009, 10.1161/HYPERTENSIONAHA.109.130781  [Abstract] [PDF]

{alpha}1-AMP-Activated Protein Kinase Regulates Hypoxia-Induced Na,K-ATPase Endocytosis via Direct Phosphorylation of Protein Kinase C{zeta}
Galina A. Gusarova, Laura A. Dada, Aileen M. Kelly, Chaya Brodie, Lee A. Witters, Navdeep S. Chandel, and Jacob I. Sznajder
Mol. Cell. Biol. 2009; 29:3455-3464.  [Abstract] [Full Text] [PDF]

Activation of Protein Kinase C {alpha} Is Necessary for Sorting the PDGF モ-Receptor to Rab4a-dependent Recycling
Carina Hellberg, Christian Schmees, Susann Karlsson, Aive Åhgren, and Carl-Henrik Heldin
Mol. Biol. Cell. 2009; 20:2856-2863.  [Abstract] [Full Text] [PDF]

Sustained Receptor Stimulation Leads to Sequestration of Recycling Endosomes in a cPKC and PLD-Dependent Manner
Jolanta Idkowiak-Baldys, Aleksander Baldys, John R. Raymond, and Yusuf A. Hannun
J. Biol. Chem. published 11 June 2009, 10.1074/jbc.M109.026765  [Abstract] [PDF]

Protein kinase C {theta} (PKC{theta}) expression as a potential diagnostic marker for KIT-negative GIST
D. A. Braggio, S. Romano, I. A. Small, F. A. Soares, C. G. Ferreira, and D. P. Guimarães
ASCO Meeting Abstracts. 2009; 27:10561.  [Abstract]

Steel factor enhances supraoptimal antigen-induced IL-6 production from mast cells via activation of protein kinase C-beta.
K Fehrenbach, E Lessmann, CN Zorn, M Kuhny, G Grochowy, G Krystal, M Leitges, and M Huber
J Immunol. 2009; 182: 7897. [MEDLINE Citation]

Role of protein kinase C in regulation of Na+- and K +-dependent ATPase activity and pump function in corneal endothelial cells.
S Hatou, M Yamada, H Mochizuki, and T Nishida
Jpn J Ophthalmol. 2009; 53: 235. [MEDLINE Citation]

Periadventitial adipose tissue impairs coronary endothelial function via PKC-{beta} dependent phosphorylation of nitric oxide synthase.
Gregory A Payne, H Glenn Bohlen, U Deniz Dincer, Lena Borbouse, and Johnathan D Tune
Am J Physiol Heart Circ Physiol. 2009. [MEDLINE Citation]

Role of protein kinase C in regulation of Na+- and K +-dependent ATPase activity and pump function in corneal endothelial cells.
S Hatou, M Yamada, H Mochizuki, and T Nishida
Jpn J Ophthalmol. 2009; 53: 235. [MEDLINE Citation]

Pivotal Advance: PKCzeta is required for migration of macrophages
Hua Guo, Yongjie Ma, Baogang Zhang, Baocun Sun, Ruifang Niu, Guoguang Ying, and Ning Zhang
J. Leukoc. Biol. 2009; 85:911-918.  [Abstract] [Full Text] [PDF]

Activation of Intracellular Signaling Pathways by the MCMV GPCR M33 Occurs Via PLC-{beta}/PKC Dependent and Independent Mechanisms
Joseph D. Sherrill, Melissa P. Stropes, Olivia D. Schneider, Diana E. Koch, Fabiola M. Bittencourt, Jeanette L.C. Miller, and William E. Miller
J. Virol. published 3 June 2009, 10.1128/JVI.02116-08  [Abstract] [PDF]

The potent protein kinase C selective inhibitor AEB071 (Sotrastaurin)represents a new class of immunosuppressive agents affecting early T cell activation
Jean-Pierre Evenou, Juergen Wagner, Gerhard Zenke, Volker Brinkmann, Kathrin Wagner, Jiri Kovarik, Karl Welzenbach, Gabriele Weitz-Schmidt, Christine Guntermann, Harry Towbin, Sylvain Cottens, Sandra Kaminski, Thomas Letschka, Christina Lutz-Nicoladoni, Thomas Gruber, Natascha Hermann-Kleiter, Nikolaus Thuille, and Gottfried Baier
J. Pharmacol. Exp. Ther. published 2 June 2009, 10.1124/jpet.109.153205  [Abstract] [PDF]