March 2009

Activation of Dual Oxidases Duox1 and Duox2: DIFFERENTIAL REGULATION MEDIATED BY cAMP-DEPENDENT PROTEIN KINASE AND PROTEIN KINASE C-DEPENDENT PHOSPHORYLATION
Sabrina Rigutto, Candice Hoste, Helmut Grasberger, Milutin Milenkovic, David Communi, Jacques E. Dumont, Bernard Corvilain, Françoise Miot, and Xavier De Deken
J. Biol. Chem. 2009; 284:6725-6734.  [Abstract] [Full Text] [PDF]

Protein kinase C-mediated phosphorylation and activation of PDE3A regulates cAMP levels in human platelets
Roger W. Hunter, Carol MacKintosh, and Ingeborg Hers
J. Biol. Chem. published 4 March 2009, 10.1074/jbc.M807536200  [Abstract] [PDF]

Marinobufagenin Induces Increases in Procollagen Expression in a Process Involving Protein Kinase C and Fli-1: Implications for Uremic Cardiomyopathy
Jihad Elkareh, Sankaridrug M Periyasamy, Amjad Shidyak, Sandeep Vetteth, Jeremy Schroeder, Vanamala Raju, Imad M. Hariri, Nasser El-Okdi, Shalini Gupta, Larisa V. Fedorova, Jiang Liu, Olga V. Fedorova, Mohamed Bashar Kahaleh, Zijian Xie, Deepak Malhotra, Dennis K Watson, Alexei Y Bagrov, and Joseph Isaac Shapiro
Am J Physiol Renal Physiol. published 4 March 2009, 10.1152/ajprenal.90710.2008  [Abstract] [PDF]

The influenza A virus proteins PB1 and NS1 are subject to functionally important phosphorylation by protein kinase C
Shohreh Mahmoudian, Sabrina Auerochs, Monika Gröne, and Manfred Marschall
J. Gen. Virol. published 4 March 2009, 10.1099/vir.0.009050-0  [Abstract]

Phosphoinositide 3-kinase Akt signaling pathway interacts with protein kinase C¥â2 in the regulation of physiologic developmental hypertrophy and heart function
Debra L. Rigor, Natalya Bodyak, Soochan Bae, Jun H. Choi, Li Zhang, Dmitry Ter-Ovanesyan, Zhiheng He, Julie R. McMullen, Tetsuo Shioi, Seigo Izumo, George L. King, and Peter M. Kang
Am J Physiol Heart Circ Physiol. 2009; 296:H566-H572.  [Abstract] [Full Text] [PDF]

PKC-¥â1 Mediates Glucose-Induced Akt Activation and TGF-¥â1 Upregulation in Mesangial Cells
Dongcheng Wu, Fangfang Peng, Baifang Zhang, Alistair J. Ingram, Darren J. Kelly, Richard E. Gilbert, Bo Gao, and Joan C. Krepinsky
J. Am. Soc. Nephrol. 2009; 20:554-566.  [Abstract] [Full Text] [PDF]

miR-205 Exerts Tumor-Suppressive Functions in Human Prostate through Down-regulation of Protein Kinase C{varepsilon}
Paolo Gandellini, Marco Folini, Nicole Longoni, Marzia Pennati, Mara Binda, Maurizio Colecchia, Roberto Salvioni, Rosanna Supino, Roberta Moretti, Patrizia Limonta, Riccardo Valdagni, Maria Grazia Daidone, and Nadia Zaffaroni
Cancer Res. 2009. [MEDLINE Citation]

Protein kinase C alpha (PKCalpha) regulates growth and invasion of endometrial cancer cells.
James M Haughian and Andrew P Bradford
J Cell Physiol. 2009. [MEDLINE Citation]

Protein kinase C intervention-the state of play.
Jon Roffey, Carine Rosse, Mark Linch, Andrew Hibbert, Neil Q McDonald, and Peter J Parker
Curr Opin Cell Biol. 2009. [MEDLINE Citation]

Amygdala Protein Kinase C Epsilon Controls Alcohol Consumption.
Heidi M B Lesscher, Melisa J Wallace, Lily Zeng, Victoria Wang, J Kevin Deitchman, Thomas McMahon, Robert O Messing, and Philip M Newton
Genes Brain Behav. 2009. [MEDLINE Citation]

Role of protein kinase C-iota in transformed non-malignant RWPE-1 cells and androgen-independent prostate carcinoma DU-145 cells.
H Y Win and M Acevedo-Duncan
Cell Prolif. 2009. [MEDLINE Citation]

Suppression of hepatitis C virus replication by protein kinase C-related kinase 2 inhibitors that block phosphorylation of viral RNA polymerase.
S-J Kim, J-H Kim, J-M Sun, M-G Kim, and J-W Oh
J Viral Hepat. 2009. [MEDLINE Citation]

Ferritin functions as a proinflammatory cytokine via iron-independent protein kinase C zeta/nuclear factor kappaB-regulated signaling in rat hepatic stellate cells.
Richard G Ruddell, Diem Hoang-Le, Joanne M Barwood, Paul S Rutherford, Terrance J Piva, Dianne J Watters, Paolo Santambrogio, Paolo Arosio, and Grant A Ramm
Hepatology. 2008; 49: 887. [MEDLINE Citation]

A cellular model of Alzheimer's disease therapeutic efficacy: PKC activation reverses Abeta-induced biomarker abnormality on cultured fibroblasts.
Tapan K Khan, Thomas J Nelson, Vishal A Verma, Paul A Wender, and Daniel L Alkon
Neurobiol Dis. 2009. [MEDLINE Citation]

PI3K Acts in synergy with loss of PKC to elicit apoptosis via the UPR.
Jinjin Guo, Tongbo Zhu, Ling-Yu Luo, Yi Huang, Raja G Sunkavalli, and Chang Yan Chen
J Cell Biochem. 2009. [MEDLINE Citation]

Cytokine production through PKC/p38 signaling pathways, not through JAK/STAT1 pathway, in mast cells stimulated with IFNgamma.
Jung Youn Seo, Dae Yong Kim, Yun Song Lee, and Jai Youl Ro
Cytokine. 2009. [MEDLINE Citation]

PKC activation and PIP(2) depletion underlie biphasic regulation of IKs by Gq-coupled receptors.
Alessandra Matavel and Coeli M B Lopes
J Mol Cell Cardiol. 2009. [MEDLINE Citation]

ARC (NSC 188491) has identical activity to Sangivamycin (NSC 65346) including inhibition of both P-TEFb and PKC.
Luke H Stockwin, Sherry X Yu, Howard Stotler, Melinda G Hollingshead, and Dianne L Newton
BMC Cancer. 2009; 9: 63. [MEDLINE Citation]

Angiotensin II Induces Renal Plasminogen Activator Inhibitor-1 and Cyclooxygenase-2 Expression Posttranscriptionally via Activation of the mRNA-Stabilizing Factor Human-Antigen R.
Anke Doller, Stefan Gauer, Ewelina Sobkowiak, Helmut Geiger, Josef Pfeilschifter, and Wolfgang Eberhardt
Am J Pathol. 2009. [MEDLINE Citation]

EFFECTS OF THAPSIGARGIN AND PHENYLEPHRINE ON CALCINEURIN AND PROTEIN KINASE C SIGNALING FUNCTIONS IN CARDIAC MYOCYTES.
Anand Mohan Prasad and Giuseppe Inesi
Am J Physiol Cell Physiol. 2009. [MEDLINE Citation]

Targeting the protein kinase C family in the diabetic kidney: lessons from analysis of mutant mice.
M Meier, J Menne, and H Haller
Diabetologia. 2009. [MEDLINE Citation]

PKCalpha tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1.
Marybeth A Pysz, Olga V Leontieva, Nicholas W Bateman, Joshua M Uronis, Kathryn J Curry, David W Threadgill, Klaus-Peter Janssen, Sylvie Robine, Anna Velcich, Leonard Augenlicht, Adrian R Black, and Jennifer D Black
Exp Cell Res. 2009. [MEDLINE Citation]

Neuroprotective versus tumorigenic protein kinase C activators.
T J Nelson and D L Alkon
Trends Biochem Sci. 2009. [MEDLINE Citation]

Meta-analysis of Oncogenic Protein Kinase C{iota} Signaling in Lung Adenocarcinoma
Eda Erdogan, Eric W. Klee, E. Aubrey Thompson, and Alan P. Fields
Clin. Cancer Res. 2009; 15:1527-1533.  [Abstract] [Full Text] [PDF]