December 2008

Effect of Protein Kinase C¥â Inhibition on Renal Hemodynamic Function and Urinary Biomarkers in Humans With Type 1 Diabetes: A Pilot Study
David Z.I. Cherney, Ana Konvalinka, Bernard Zinman, Eleftherios P. Diamandis, Anton Soosaipillai, Heather Reich, Joanne Lorraine, Vesta Lai, James W. Scholey, and Judith A. Miller
Diabetes Care. 2009; 32:91-93.  [Abstract] [Full Text] [PDF]

African Swine Fever Virus Blocks the Host Cell Antiviral Inflammatory Response through a Direct Inhibition of PKC-{theta}-Mediated p300 Transactivation
Aitor G. Granja, Elena G. Sánchez, Prado Sabina, Manuel Fresno, and Yolanda Revilla
J. Virol. 2009; 83:969-980.  [Abstract] [Full Text] [PDF]

Aldose Reductase Regulates High Glucose-Induced Ectodomain Shedding of Tumor Necrosis Factor (TNF)-{alpha} via Protein Kinase C-{delta} and TNF-{alpha} Converting Enzyme in Vascular Smooth Muscle Cells
Aramati B. M. Reddy, Kota V. Ramana, Sanjay Srivastava, Aruni Bhatnagar, and Satish K. Srivastava
Endocrinology. 2009; 150:63-74.  [Abstract] [Full Text] [PDF]

Role of Dosage-Sensitive Sex Reversal, Adrenal Hypoplasia Congenita, Critical Region on the X Chromosome, Gene 1 in Protein Kinase A- and Protein Kinase C-Mediated Regulation of the Steroidogenic Acute Regulatory Protein Expression in Mouse Leydig Tumor Cells: Mechanism of Action
Pulak R. Manna, Matthew T. Dyson, Youngah Jo, and Douglas M. Stocco
Endocrinology. 2009; 150:187-199.  [Abstract] [Full Text] [PDF]

PKC{eta} regulates occludin phosphorylation and epithelial tight junction integrity
Takuya Suzuki, Bertha C. Elias, Ankur Seth, Le Shen, Jerrold R. Turner, Francesco Giorgianni, Dominic Desiderio, Ramareddy Guntaka, and Radhakrishna Rao
PNAS. published 29 December 2008, 10.1073/pnas.0802741106  [Abstract] [PDF]

Ca2+ Entry via TRPC Channels Is Necessary for Thrombin-induced NF-{kappa}B Activation in Endothelial Cells through AMP-activated Protein Kinase and Protein Kinase C{delta}
Angela M. Bair, Prabhakar B. Thippegowda, Marc Freichel, Ni Cheng, Richard D. Ye, Stephen M. Vogel, Yanni Yu, Veit Flockerzi, Asrar B. Malik, and Chinnaswamy Tiruppathi
J. Biol. Chem. 2009; 284:563-574.  [Abstract] [Full Text] [PDF]

SARS-CoV Proteins Decrease Levels and Activity of Human ENaC via Activation of Distinct PKC Isoforms
Hong-Long Ji, Weifeng Song, Zhiqian Gao, Xue-Feng Su, Hong-Guang Nie, Yi Jiang, Ji-Bin Peng, Yu-Xian He, Ying Liao, Yong-Jian Zhou, Albert Tousson, and Sadis Matalon
Am J Physiol Lung Cell Mol Physiol. published 26 December 2008, 10.1152/ajplung.90437.2008  [Abstract] [PDF]

Negative Regulation of Class IA Phosphoinositide 3-kinase by Protein Kinase C{delta} Limits Fc{gamma} Receptor-Mediated Phagocytosis in Macrophages
Kaoru Hazeki, Kazumi Inoue, Kiyomi Nigorikawa, and Osamu Hazeki
J. Biochem. 2009; 145:87-94.  [Abstract] [Full Text] [PDF]

Protein kinase C-dependent {alpha}-secretory processing of the amyloid precursor protein is mediated by phosphorylation of myosin II-B
Francesca Argellati, Cinzia Domenicotti, Mario Passalacqua, Elzbieta Janda, Edon Melloni, Umberto M. Marinari, Maria A. Pronzato, and Roberta Ricciarelli
FASEB J. published 22 December 2008, 10.1096/fj.08-119263  [Abstract]

Protein kinase C{beta} is a critical regulator of dopamine transporter trafficking and regulates the behavioral response to amphetamine in mice
Rong Chen, Cheryse A. Furman, Minjia Zhang, Myung N. Kim, Robert W. Gereau, Michael Leitges, and Margaret E. Gnegy
J. Pharmacol. Exp. Ther. published 19 December 2008, 10.1124/jpet.108.147959  [Abstract] [PDF]

Activation of P2X7 receptors causes isoform-specific translocation of protein kinase C in osteoclasts.
Souzan Armstrong, Alexey Pereverzev, S Jeffrey Dixon, and Stephen M Sims
J Cell Sci. 2008. [MEDLINE Citation]

Wnt5a Is Required for Endothelial Differentiation of Embryonic Stem Cells and Vascularization via Pathways Involving Both Wnt/{beta}-Catenin and Protein Kinase C{alpha}
Dong-Hwa Yang, Ju-Young Yoon, Soung-Hoon Lee, Vitezslav Bryja, Emma R. Andersson, Ernest Arenas, Young-Guen Kwon, and Kang-Yell Choi
Circ. Res. published 18 December 2008, 10.1161/CIRCRESAHA.108.185405  [Abstract] [PDF]

Two PKC consensus sites on human Acid- Sensing Ion Channel 1b (hASIC1b) differentially regulate its function
Edlira Bashari, Yawar Qadri, Zhen-Hong Zhou, Niren Kapoor, Susan Anderson, Robert Meltzer, Catherine M Fuller, and Dale J Benos
Am J Physiol Cell Physiol. published 17 December 2008, 10.1152/ajpcell.00200.2008  [Abstract] [PDF]

Activation of P2X7 receptors causes isoform-specific translocation of protein kinase C in osteoclasts
Souzan Armstrong, Alexey Pereverzev, S. Jeffrey Dixon, and Stephen M. Sims
J. Cell Sci. 2009; 122:136-144.  [Abstract] [Full Text] [PDF]

The chaperones Hsp90 and Cdc37 mediate the maturation and stabilization of protein kinase C through a conserved PXXP motif in the C-terminal tail
Christine M. Gould, Natarajan Kannan, Susan S. Taylor, and Alexandra C. Newton
J. Biol. Chem. published 17 December 2008, 10.1074/jbc.M808436200  [Abstract] [PDF]

Activation of P2X7 receptors causes isoform-specific translocation of protein kinase C in osteoclasts
Souzan Armstrong, Alexey Pereverzev, S. Jeffrey Dixon, and Stephen M. Sims
J. Cell Sci. 2009; 122:136-144.  [Abstract] [Full Text] [PDF]

Regulation of Human Organic Anion Transporter 1 by Angiotensin II: Involvement of Protein Kinase C{alpha}
Shanshan Li, Peng Duan, and Guofeng You
Am J Physiol Endocrinol Metab. published 16 December 2008, 10.1152/ajpendo.90713.2008  [Abstract] [PDF]

Role of Protein Kinase C{alpha} in Regulation of [Ca2+]1 and Force in Human Myometrium
Victor P. Fomin, Andris Kronbergs, Susan Gunst, Dale Tang, Vladimir Simirskii, Matthew Hoffman, and Randall L. Duncan
Reproductive Sciences. published 15 December 2008, 10.1177/1933719108324892  [Abstract]

PKC{alpha} Stimulates Conjunctival Goblet Cell Proliferation Using Extracellular Regulated Kinase 1/2
Marie A. Shatos, Robin R. Hodges, Jeffrey A. Bair, Kameran Lashkari, and Darlene A. Dartt
Invest. Ophthalmol. Vis. Sci. published 13 December 2008, 10.1167/iovs.08-2930  [Abstract]

Protein kinase Cdelta and PI3-kinase/Akt activate mammalian target of rapamycin to modulate NF-kappa B activation and ICAM-1 expression in endothelial cells
Mohd Minhajuddin, Kaiser M. Bijli, Fabeha Fazal, Antonella Sassano, Keiichi I. Nakayama, Nissim Hay, Leonidas C. Platanias, and Arshad Rahman
J. Biol. Chem. published 13 December 2008, 10.1074/jbc.M805032200  [Abstract] [PDF]

Protein Kinase C{zeta} Represses the Interleukin-6 Promoter and Impairs Tumorigenesis In Vivo
Anita S. Galvez, Angeles Duran, Juan F. Linares, Peterson Pathrose, Elias A. Castilla, Shadi Abu-Baker, Michael Leitges, Maria T. Diaz-Meco, and Jorge Moscat
Mol. Cell. Biol. 2009; 29:104-115.  [Abstract] [Full Text] [PDF]

Protein kinase C mediates amyloid beta-protein fragment 31-35-induced suppression of hippocampal late-phase long-term potentiation in vivo.
Jun-Fang Zhang, Jin-Shun Qi, and Jian-Tian Qiao
Neurobiol Learn Mem. 2008. [MEDLINE Citation]

Overexpression of Protein Kinase C-delta Plays a Crucial Role in Interleukin-6-Producing Pheochromocytoma Presenting with Acute Inflammatory Syndrome: A Case Report.
H Tokuda, T Hosoi, K Hayasaka, K Okamura, N Yoshimi, and O Kozawa
Horm Metab Res. 2008. [MEDLINE Citation]

Distinct Roles of Protein Kinase C Isoforms in Myogenic Constriction of Rat Posterior Cerebral Arteries.
Toshihide Kashihara, Koichi Nakayama, and Tomohisa Ishikawa
J Pharmacol Sci. 2008. [MEDLINE Citation]

Berberine reduces insulin resistance through protein kinase C-dependent up-regulation of insulin receptor expression.
WJ Kong, H Zhang, DQ Song, R Xue, W Zhao, J Wei, YM Wang, N Shan, ZX Zhou, P Yang, XF You, ZR Li, SY Si, LX Zhao, HN Pan, and JD Jiang
Metabolism. 2009; 58: 109. [MEDLINE Citation]

Rationally designed peptide regulators of protein kinase C.
Eric N Churchill, Nir Qvit, and Daria Mochly-Rosen
Trends Endocrinol Metab. 2008. [MEDLINE Citation]

Locally Generated Methylseleninic Acid Induces Specific Inactivation of Protein Kinase C Isoenzymes: RELEVANCE TO SELENIUM-INDUCED APOPTOSIS IN PROSTATE CANCER CELLS
Usha Gundimeda, Jason Eric Schiffman, Divya Chhabra, Jourdan Wong, Adela Wu, and Rayudu Gopalakrishna
J. Biol. Chem. 2008; 283:34519-34531.  [Abstract] [Full Text] [PDF]

Protein Kinase C{delta} Differentially Regulates Platelet Functional Responses.
Ramya Chari, Todd Getz, Bela Nagy, Kamala Bhavaraju, Yingying Mao, Yamini Saraswathy Bynagari, Swaminathan Murugappan, Keiko Nakayama, James Daniel, and Satya P. Kunapuli
Blood (ASH Annual Meeting Abstracts). 2008; 112:1841.  [Abstract]

Impaired Activation of Platelets Lacking Protein Kinase C Theta (PKC{Theta}) Isoform.
Bela Nagy, Kamala Bhavaraju, Todd Getz, Yamini Saraswathy Bynagari, Soochong Kim, and Satya P. Kunapuli
Blood (ASH Annual Meeting Abstracts). 2008; 112:1845.  [Abstract]

Protein Kinase C-Epsilon Is An Important Component of the Lyn Kinase Signaling Pathway in the Apoptotic Resistance of B- Chronic Lymphocytic Leukemia Cells.
Vamsidhar Velcheti, Srikanth Tamma, Zoe L Larned, Jyotsna Fuloria, Li Li, Francis R Rodwig, John T. Cole, Felipe Samaniego, and Om Prakash
Blood (ASH Annual Meeting Abstracts). 2008; 112:2087.  [Abstract]

Tumor-Mediated Suppression of Myeloid to Dendritic Cell Differentiation Via Down Regulation of Protein Kinase C ¥âII Expression
Matthew R. Farren, Louise M Carlson, and Kelvin P. Lee
Blood (ASH Annual Meeting Abstracts). 2008; 112:678.  [Abstract]

Red Blood Cell Scramblase Activation Is Induced by Phorbol Ester and Prevented by Inhibition of Protein Kinase C
Latorya Arnold Barber, Mary B Palascak, Clinton H. Joiner, and Robert S. Franco
Blood (ASH Annual Meeting Abstracts). 2008; 112:2494.  [Abstract]

Locally Generated Methylseleninic Acid Induces Specific Inactivation of Protein Kinase C Isoenzymes: RELEVANCE TO SELENIUM-INDUCED APOPTOSIS IN PROSTATE CANCER CELLS
Usha Gundimeda, Jason Eric Schiffman, Divya Chhabra, Jourdan Wong, Adela Wu, and Rayudu Gopalakrishna
J. Biol. Chem. 2008; 283:34519-34531.  [Abstract] [Full Text] [PDF]

Direct association of calponin with specific domains of PKC-{alpha}
Sita Somara and Khalil N. Bitar
Am J Physiol Gastrointest Liver Physiol. 2008; 295:G1246-G1254.  [Abstract] [Full Text] [PDF]

High glucose activates PKC-{zeta} and NADPH oxidase through autocrine TGF-¥â1 signaling in mesangial cells
Ling Xia, Hong Wang, Snezana Munk, Janice Kwan, Howard J. Goldberg, I. George Fantus, and Catharine I. Whiteside
Am J Physiol Renal Physiol. 2008; 295:F1705-F1714.  [Abstract] [Full Text] [PDF]

Induction of HIV Transcription by Nef Involves Lck Activation and Protein Kinase C{theta} Raft Recruitment Leading to Activation of ERK1/2 but Not NF{kappa}B
Vanessa Witte, Bernd Laffert, Patricia Gintschel, Ellen Krautkrämer, Katja Blume, Oliver T. Fackler, and Andreas S. Baur
J. Immunol. 2008; 181:8425-8432.  [Abstract] [Full Text] [PDF]

Glucose-dependent enhancement of diabetic bladder contraction is associated with a rho kinase-regulated protein kinase C pathway
Koji Nobe, Taigi Yamazaki, Naoki Tsumita, Terumasa Hashimoto, and Kazuo Honda
J. Pharmacol. Exp. Ther. published 2 December 2008, 10.1124/jpet.108.144907  [Abstract] [PDF]

Deletion of SM-B, the high ATPase isoform of myosin, upregulates the PKC-mediated signal transduction pathway in murine urinary bladder smooth muscle
Joseph A Hypolite, Shaohua Chang, Edward F LaBelle, Gopal J Babu, Muthu Periasamy, Alan J. Wein, and Samuel Chacko
Am J Physiol Renal Physiol. published 3 December 2008, 10.1152/ajprenal.90221.2008  [Abstract] [PDF]

PKCtheta-dependent phosphorylation of PDK1 at SER504 and SER532 contributes to palmitate-induced insulin resistance
Changhua Wang, Meilian Liu, Ramon A. Riojas, Xiaoban Xin, Zhanguo Gao, Rong Zeng, Jiarui Wu, Lily Q. Dong, and Feng Liu
J. Biol. Chem. published 1 December 2008, 10.1074/jbc.M806336200  [Abstract] [PDF]

Rottlerin induces apoptosis via death receptor5 (DR5) up-regulation through CHOP-dependent and PKC {delta}-independent mechanism in human malignant tumor cells.
Jun Hee Lim, Jong-Wook Park, Kyeong Sook Choi, Yong Bok Park, and Taeg Kyu Kwon
Carcinogenesis. 2008. [MEDLINE Citation]

Mice deficient in PKC{beta} and apolipoprotein E display decreased atherosclerosis.
Evis Harja, Jong Sun Chang, Yan Lu, Michael Leitges, Yu Shan Zou, Ann Marie Schmidt, and Shi-Fang Yan
FASEB J. 2008. [MEDLINE Citation]

PKC-dependent Stimulation of the Human MCT1 Promoter Involves Transcription Factor AP2.
Seema Saksena, Alka Dwivedi, Ravinder K Gill, Amika Singla, Waddah A Alrefai, Jaleh Malakooti, Krishnamurthy Ramaswamy, and Pradeep K Dudeja
Am J Physiol Gastrointest Liver Physiol. 2008. [MEDLINE Citation]

Activation of protein kinase C zeta increases OAT1 (SLC22A6) and OAT3 (SLC22A8)-mediated transport.
Scott A Barros, Chutima Srimaroeng, Jennifer L Perry, Ramsey Walden, Neetu Dembla-Rajpal, Douglas H Sweet, and John B Pritchard
J Biol Chem. 2008. [MEDLINE Citation]

Differential Roles of the PKC Novel Isoforms, PKCdelta and PKCepsilon, in Mouse and Human Platelets.
CJ Pears, K Thornber, JM Auger, CE Hughes, B Grygielska, MB Protty, AC Pearce, and SP Watson
PLoS ONE. 2008; 3: e3793. [MEDLINE Citation]

Involvement of PKC signal pathways in oridonin-induced autophagy in HeLa cells: A protective mechanism against apoptosis.
Yahong Zhang, Yingliang Wu, Shin-Ichi Tashiro, Satoshi Onodera, and Takashi Ikejima
Biochem Biophys Res Commun. 2008. [MEDLINE Citation]

Antiproliferative activity of PEP005, a novel ingenol angelate that modulates PKC functions, alone and in combination with cytotoxic agents in human colon cancer cells.
K A Benhadji, M Serova, A Ghoul, E Cvitkovic, C Le Tourneau, S M Ogbourne, F Lokiec, F Calvo, P Hammel, S Faivre, and E Raymond
Br J Cancer. 2008; 99: 1808. [MEDLINE Citation]

Role of potein kinase C and phosphoinositide 3-kinase-Akt in substance P-induced proinflammatory pathways in mouse macrophages.
Jia Sun, Raina Devi Ramnath, Ramasamy Tamizhselvi, and Madhav Bhatia
FASEB J. 2008. [MEDLINE Citation]

Regulation of the phagocyte NADPH oxidase activity: phosphorylation of gp91phox/NOX2 by protein kinase C enhances its diaphorase activity and binding to Rac2, p67phox, and p47phox.
Houssam Raad, Marie-Helene Paclet, Tarek Boussetta, Yolande Kroviarski, Francoise Morel, Mark T Quinn, Marie-Anne Gougerot-Pocidalo, Pham My-Chan Dang, and Jamel El-Benna
FASEB J. 2008. [MEDLINE Citation]