November 2008

CD28 stimulation triggers NF-{kappa}B activation through the CARMA1–PKC{theta}–Grb2/Gads axis
Kei Takeda, Yohsuke Harada, Ryosuke Watanabe, Yuu Inutake, Shuhei Ogawa, Kazunobu Onuki, Saori Kagaya, Kazunari Tanabe, Hidehiro Kishimoto, and Ryo Abe
Int. Immunol. 2008; 20:1507-1515.  [Abstract] [Full Text] [PDF]

Ethanol for cardiac ischemia: the role of protein kinase c
Eric N. Churchill, Marie-Helene Disatnik, Grant R. Budas, and Daria Mochly-Rosen
Therapeutic Advances in Cardiovascular Disease. 2008; 2:469-483.  [Abstract] [PDF]

Mice deficient in PKC{beta} and apolipoprotein E display decreased atherosclerosis
Evis Harja, Jong Sun Chang, Yan Lu, Michael Leitges, Yu Shan Zou, Ann Marie Schmidt, and Shi-Fang Yan
FASEB J. published 26 November 2008, 10.1096/fj.08-120345  [Abstract]

Doing protein kinase C: membrane estrogen receptor signaling in a neural circuit.
RL Meisel
Endocrinology. 2008; 149: 5932. [MEDLINE Citation]

PKC{delta) negatively regulates hedgehog signaling by inhibition of Gli1 activity.
Qingsong Cai, Jing Li, Tianyan Gao, Jingwu Xie, and B Mark Evers
J Biol Chem. 2008. [MEDLINE Citation]

PKC-{theta} selectively controls the adhesion-stimulating molecule Rap1
Thomas Letschka, Veronika Kollmann, Christa Pfeifhofer-Obermair, Christina Lutz-Nicoladoni, Gerald J. Obermair, Friedrich Fresser, Michael Leitges, Natascha Hermann-Kleiter, Sandra Kaminski, and Gottfried Baier
Blood. 2008; 112:4617-4627.  [Abstract] [Full Text] [PDF]

Role of potein kinase C and phosphoinositide 3-kinase-Akt in substance P-induced proinflammatory pathways in mouse macrophages
Jia Sun, Raina Devi Ramnath, Ramasamy Tamizhselvi, and Madhav Bhatia
FASEB J. published 24 November 2008, 10.1096/fj.08-121756  [Abstract]

Regulation of the phagocyte NADPH oxidase activity: phosphorylation of gp91phox/NOX2 by protein kinase C enhances its diaphorase activity and binding to Rac2, p67phox, and p47phox
Houssam Raad, Marie-Hélène Paclet, Tarek Boussetta, Yolande Kroviarski, Françoise Morel, Mark T. Quinn, Marie-Anne Gougerot-Pocidalo, Pham My-Chan Dang, and Jamel El-Benna
FASEB J. published 21 November 2008, 10.1096/fj.08-114553  [Abstract]

Activation of protein kinase C zeta increases OAT1 (SLC22A6) and OAT3 (SLC22A8)-mediated transport
Scott A. Barros, Chutima Srimaroeng, Jennifer L. Perry, Ramsey Walden, Neetu Dembla-Rajpal, Douglas H. Sweet, and John B. Pritchard
J. Biol. Chem. published 21 November 2008, 10.1074/jbc.M808078200  [Abstract] [PDF]

Doing Protein Kinase C: Membrane Estrogen Receptor Signaling in a Neural Circuit
Robert L. Meisel
Endocrinology. 2008; 149:5932-5933.  [Full Text] [PDF]

Protein Kinase C Signaling in the Hypothalamic Arcuate Nucleus Regulates Sexual Receptivity in Female Rats
Phoebe Dewing, Amy Christensen, Galyna Bondar, and Paul Micevych
Endocrinology. 2008; 149:5934-5942.  [Abstract] [Full Text] [PDF]

Regulation of the phagocyte NADPH oxidase activity: phosphorylation of gp91phox/NOX2 by protein kinase C enhances its diaphorase activity and binding to Rac2, p67phox, and p47phox
Houssam Raad, Marie-Hélène Paclet, Tarek Boussetta, Yolande Kroviarski, Françoise Morel, Mark T. Quinn, Marie-Anne Gougerot-Pocidalo, Pham My-Chan Dang, and Jamel El-Benna
FASEB J. published 21 November 2008, 10.1096/fj.08-114553  [Abstract]

Advanced oxidation protein products induce mesangial cells perturbation through PKC-dependent activation of NADPH oxidase
Xiao Fan Wei, Qiu Gen Zhou, Fan Fan Hou, Bei Yi Liu, and Min Liang
Am J Physiol Renal Physiol. published 19 November 2008, 10.1152/ajprenal.90536.2008  [Abstract] [PDF]

PKC{delta) negatively regulates hedgehog signaling by inhibition of Gli1 activity
Qingsong Cai, Jing Li, Tianyan Gao, Jingwu Xie, and B. Mark Evers
J. Biol. Chem. published 17 November 2008, 10.1074/jbc.M803235200  [Abstract] [PDF]

Inhibition of Protein Kinase C¥â Prevents Foam Cell Formation by Reducing Scavenger Receptor A Expression in Human Macrophages
Elena Osto, Alexei Kouroedov, Pavani Mocharla, Alexander Akhmedov, Christian Besler, Lucia Rohrer, Arnold von Eckardstein, Sabino Iliceto, Massimo Volpe, Thomas F. Lüscher, and Francesco Cosentino
Circulation. 2008; 118:2174-2182.  [Abstract] [Full Text] [PDF]

Role of PKC{zeta} and Calcium Entry in KCl-Induced Vascular Smooth Muscle Calcium Sensitization and Feed Back Control of Cellular Calcium Levels
Paul H. Ratz and Amy S. Miner
J. Pharmacol. Exp. Ther. published 14 November 2008, 10.1124/jpet.108.142422  [Abstract] [PDF]

PKC Inhibitor Inhibits Psoriasis
Journal Watch Dermatology. 2008; 2008:3.  [Full Text]

Organic Anion Transporter OAT1 Undergoes Constitutive and Protein Kinase C-regulated Trafficking through a Dynamin- and Clathrin-dependent Pathway
Qiang Zhang, Mei Hong, Peng Duan, Zui Pan, Jianjie Ma, and Guofeng You
J. Biol. Chem. 2008; 283:32570-32579.  [Abstract] [Full Text] [PDF]

Protein Kinase C-{epsilon} Regulates Local Calcium Signaling in Airway Smooth Muscle Cells
Qing-Hua Liu, Yun-Min Zheng, Amit S Korde, Xiao-Qiang Li, Jianjie Ma, Hiroshi Takeshima, and Yong-Xiao Wang
Am. J. Respir. Cell Mol. Biol. published 14 November 2008, 10.1165/rcmb.2008-0323OC  [Abstract] [PDF]

PKC phosphorylation modulates PKA-dependent binding of the R domain to other domains of CFTR
Gage Seavilleklein, Noha Amer, Alexandra Evagelidis, Frédéric Chappe, Thomas Irvine, John W. Hanrahan, and Valérie Chappe
Am J Physiol Cell Physiol. 2008; 295:C1366-C1375.  [Abstract] [Full Text] [PDF]

Protein Kinase C{delta} Regulates Ethanol Intoxication and Enhancement of GABA-Stimulated Tonic Current
Doo-Sup Choi, Weizheng Wei, J. Kevin Deitchman, Viktor N. Kharazia, Heidi M. B. Lesscher, Thomas McMahon, Dan Wang, Zhan-Heng Qi, Werner Sieghart, Chao Zhang, Kevan M. Shokat, Istvan Mody, and Robert O. Messing
J. Neurosci. 2008; 28:11890-11899.  [Abstract] [Full Text] [PDF]

Protein kinase C-beta inhibition for diabetic kidney disease.
Katherine R Tuttle
Diabetes Res Clin Pract. 2008. [MEDLINE Citation]

Protein kinase C mediated inhibition of endothelial l-arginine transport is mediated by MARCKS protein.
Kylie Venardos, Carla Enriquez, Tanneale Marshall, Jaye P F Chin-Dusting, Belinda Ahlers, and David M Kaye
J Mol Cell Cardiol. 2008. [MEDLINE Citation]

Phorbol ester-induced PKC{epsilon} down-modulation sensitizes AML cells to TRAIL-induced apoptosis and cell differentiation.
Giuliana Gobbi, Prisco Mirandola, Cecilia Carubbi, Cristina Micheloni, Chiara Malinverno, Paolo Lunghi, Antonio Bonati, and Marco Vitale
Blood. 2008. [MEDLINE Citation]

Role of Protein Kinase C in the Expression of Endothelin Converting Enzyme-1.
Mogher Khamaisi, Rachel Dahan, Saher Hamed, Zaid Abassi, Samuel N Heyman, and Itamar Raz
Endocrinology. 2008. [MEDLINE Citation]

Negative Regulation of Class IA Phosphoinositide 3-kinase by Protein Kinase C{delta} Limits Fc{gamma} Receptor-mediated Phagocytosis in Macrophages.
Kaoru Hazeki, Kazumi Inoue, Kiyomi Nigorikawa, and Osamu Hazeki
J Biochem. 2008. [MEDLINE Citation]

L-leucine increases [(3)H]-thymidine incorporation in chicken hepatocytes: Involvement of the PKC, PI3K/Akt, ERK1/2, and mTOR signaling pathways.
Min Young Lee, Sung Duk Jo, Jang Hern Lee, and Ho Jae Han
J Cell Biochem. 2008. [MEDLINE Citation]

Nicotine promotes mammary tumor migration via a signaling cascade involving protein kinase C and CDC42.
J Guo, S Ibaragi, T Zhu, LY Luo, GF Hu, PS Huppi, and CY Chen
Cancer Res. 2008; 68: 8473. [MEDLINE Citation]

Inhibition of Protein Kinase C{beta} Prevents Foam Cell Formation by Reducing Scavenger Receptor A Expression in Human Macrophages.
Elena Osto, Alexei Kouroedov, Pavani Mocharla, Alexander Akhmedov, Christian Besler, Lucia Rohrer, Arnold von Eckardstein, Sabino Iliceto, Massimo Volpe, Thomas F Luscher, and Francesco Cosentino
Circulation. 2008. [MEDLINE Citation]

Primary Clearance of Murine Gammaherpesvirus 68 by PKC{theta}–/– CD8 T Cells Is Compromised in the Absence of Help from CD4 T Cells
Peter Dias, Ashley L. Shea, Chandra Inglis, Francesca Giannoni, Lian Ni Lee, and Sally R. Sarawar
J. Virol. 2008; 82:11970-11975.  [Abstract] [Full Text] [PDF]

Characterization of the differential roles of the twin C1a and C1b domains of PKCdelta
Yongmei Pu, Susan H. Garfield, Noemi Kedei, and Peter M. Blumberg
J. Biol. Chem. published 10 November 2008, 10.1074/jbc.M804796200  [Abstract] [PDF]

NK cell–activating receptors require PKC-{theta} for sustained signaling, transcriptional activation, and IFN-{gamma} secretion
Ilaria Tassi, Marina Cella, Rachel Presti, Angela Colucci, Susan Gilfillan, Dan R. Littman, and Marco Colonna
Blood. 2008; 112:4109-4116.  [Abstract] [Full Text] [PDF]

Pharmacological Investigation of Protein Kinase C- and cGMP-Dependent Ion Channels in Cultured Olfactory Receptor Neurons of the Hawkmoth Manduca sexta
Jan Dolzer, Steffi Krannich, and Monika Stengl
Chem Senses. 2008; 33:803-813.  [Abstract] [Full Text] [PDF]

The Synthetic Genetic Network around PKC1 Identifies Novel Modulators and Components of Protein Kinase C Signaling in Saccharomyces cerevisiae
Sue A. Krause, Hong Xu, and Joseph V. Gray
Eukaryot. Cell. 2008; 7:1880-1887.  [Abstract] [Full Text] [PDF]

PKC{zeta} represses the IL-6 promoter and impairs tumorigenesis in vivo.
Anita S Galvez, Angeles Duran, Juan F Linares, Peterson Pathrose, Elias A Castilla, Shadi Abu-Baker, Michael Leitges, Maria T Diaz-Meco, and Jorge Moscat
Mol Cell Biol. 2008. [MEDLINE Citation]

PKC{zeta} represses the IL-6 promoter and impairs tumorigenesis in vivo.
Anita S Galvez, Angeles Duran, Juan F Linares, Peterson Pathrose, Elias A Castilla, Shadi Abu-Baker, Michael Leitges, Maria T Diaz-Meco, and Jorge Moscat
Mol Cell Biol. 2008. [MEDLINE Citation]

Direct Association of Calponin with Specific Domains of PKC{alpha}
Sita Somara and Khalil N Bitar
Am J Physiol Gastrointest Liver Physiol. 2008. [MEDLINE Citation]

Role of Protein Kinase C in the Expression of Endothelin Converting Enzyme-1.
Mogher Khamaisi, Rachel Dahan, Saher Hamed, Zaid Abassi, Samuel N Heyman, and Itamar Raz
Endocrinology. 2008. [MEDLINE Citation]

Structural basis of protein kinase C isoform function.
SF Steinberg
Physiol Rev. 2008; 88: 1341. [MEDLINE Citation]

Negative Regulation of Class IA Phosphoinositide 3-kinase by Protein Kinase C{delta} Limits Fc{gamma} Receptor-mediated Phagocytosis in Macrophages.
Kaoru Hazeki, Kazumi Inoue, Kiyomi Nigorikawa, and Osamu Hazeki
J Biochem. 2008. [MEDLINE Citation]

Selective PKC Beta Inhibition with Ruboxistaurin and Endothelial Function in Type-2 Diabetes Mellitus.
Nehal N Mehta, Matthew Sheetz, Karen Price, Lynn Comiskey, Shirish Amrutia, Nayyar Iqbal, Emile R Mohler, and Muredach P Reilly
Cardiovasc Drugs Ther. 2008. [MEDLINE Citation]

Ethambutol induces PKC-dependent cytotoxic and antiproliferative effects on human retinal pigment cells.
Rong Kung Tsai, Chung Hsing Chang, Chi Ming Hseu, Shen Ming Chang, Jia-Ru Wu, Hwei-Zu Wang, Wen Chen Wu, and Wen Sheng Wu
Exp Eye Res. 2008. [MEDLINE Citation]

Ursolic acid inhibits IL-1beta or TNF-alpha-induced C6 glioma invasion through suppressing the association ZIP/p62 with PKC-zeta and downregulating the MMP-9 expression.
Hsiu-Chen Huang, Chien-Yu Huang, Shoei-Yn Lin-Shiau, and Jen-Kun Lin
Mol Carcinog. 2008. [MEDLINE Citation]

High Glucose-induced Nox1-derived Superoxides Down-regulate PKC{beta}II That Subsequently Decreases ACE2 Expression and Angiotensin-(1-7) Formation in Rat VSMC
Eduard N Lavrentyev and Kafait U. Malik
Am J Physiol Heart Circ Physiol. published 31 October 2008, 10.1152/ajpheart.00239.2008  [Abstract] [PDF]