September 2008

Protein kinase C delta localizes to secretory lysosomes in CD8+ CTL and directly mediates TCR signals leading to granule exocytosis-mediated cytotoxicity.
JS Ma, TF Haydar, and S Radoja
J Immunol. 2008; 181: 4716. [MEDLINE Citation]

Protein kinase C-theta is required for efficient positive selection.
SC Morley, KS Weber, H Kao, and PM Allen
J Immunol. 2008; 181: 4696. [MEDLINE Citation]

The Synthetic Genetic Network Around PKC1 Identifies Novel Modulators and Components of Protein Kinase C Signaling in Yeast.
Sue A Krause, Hong Xu, and Joseph V Gray
Eukaryot Cell. 2008. [MEDLINE Citation]

Protein kinase Ctheta regulates stability of the peripheral adhesion ring junction and contributes to the sensitivity of target cell lysis by CTL.
AM Beal, N Anikeeva, R Varma, TO Cameron, PJ Norris, ML Dustin, and Y Sykulev
J Immunol. 2008; 181: 4815. [MEDLINE Citation]

T cell-dendritic cell immunological synapses contain TCR-dependent CD28-CD80 clusters that recruit protein kinase Ctheta.
SY Tseng, JC Waite, M Liu, S Vardhana, and ML Dustin
J Immunol. 2008; 181: 4852. [MEDLINE Citation]

Protein Kinase C Regulates the Expression of M1 Receptors and BDNF in Rat Retinal Cells.
Aline Araujo Dos Santos, Simone Vidal Medina, Leandro de Araujo Martins, and Elizabeth Giestal de Araujo
Neurochem Res. 2008. [MEDLINE Citation]

Protein kinase C-dependent and independent signaling pathways regulate synaptic GluR1 and GluR4 AMPAR subunits during in vitro, classical conditioning.
Z Zheng and J Keifer
Neuroscience. 2008. [MEDLINE Citation]

Interaction between protein kinase C and protein kinase A can modulate transmitter release at the rat neuromuscular synapse.
M M Santafe, N Garcia, M A Lanuza, M Tomas, and J Tomas
J Neurosci Res. 2008.  [MEDLINE Citation]

Rottlerin induces pro-apoptotic endoplasmic reticulum stress through the protein kinase C-delta-independent pathway in human colon cancer cells.
Jun Hee Lim, Jong-Wook Park, Sang Hyun Kim, Yung Hyun Choi, Kyeong Sook Choi, and Taeg Kyu Kwon
Apoptosis. 2008. [MEDLINE Citation]

GO6976 prevents TNF-alpha-induced suppression of adiponectin expression in 3T3-L1 adipocytes: Putative involvement of protein kinase C.
Joong-Yeon Lim, Won Ho Kim, and Sang Ick Park
FEBS Lett. 2008. [MEDLINE Citation]

High glucose activates PKC-{zeta} and NADPH oxidase through autocrine TGF-{beta}1 signaling in mesangial cells.
Ling Xia, Hong Wang, Snezana Munk, Janice Kwan, Howard J Goldberg, I George Fantus, and Catharine I Whiteside
Am J Physiol Renal Physiol. 2008. [MEDLINE Citation]

PKC phosphorylation modulates PKA-dependent binding of the R domain to other domains of CFTR.
Gage Seavilleklein, Noha Amer, Alexandra Evagelidis, Frederic Chappe, John Hanrahan, and Valerie Chappe
Am J Physiol Cell Physiol. 2008.  [MEDLINE Citation]

Protein kinase C delta localizes to secretory lysosomes in CD8+ CTL and directly mediates TCR signals leading to granule exocytosis-mediated cytotoxicity.
JS Ma, TF Haydar, and S Radoja
J Immunol. 2008; 181: 4716. [MEDLINE Citation]

Protein kinase C-theta is required for efficient positive selection.
SC Morley, KS Weber, H Kao, and PM Allen
J Immunol. 2008; 181: 4696. [MEDLINE Citation]

The Synthetic Genetic Network Around PKC1 Identifies Novel Modulators and Components of Protein Kinase C Signaling in Yeast.
Sue A Krause, Hong Xu, and Joseph V Gray
Eukaryot Cell. 2008. [MEDLINE Citation]

Constriction of pulmonary artery by peroxide: role of Ca(2+) release and PKC.
Ghazaleh Esmaeil Pourmahram, Vladimir A Snetkov, Yasin Shaifta, Svetlana Drndarski, Greg A Knock, Philip I Aaronson, and Jeremy P T Ward
Free Radic Biol Med. 2008. [MEDLINE Citation]

Substrate induced changes in density of the peptide transporter PEPT1 expressed in Xenopus oocytes.
Manuela Mertl, Hannelore Daniel, and Gabor Kottra
Am J Physiol Cell Physiol. 2008. [MEDLINE Citation]

Electrogenic NBCe1 (SLC4A4) but not electroneutral NBCn1 (SLC4A7) cotransporter undergoes cholinergic-stimulated endocytosis in salivary ParC5 cells.
Clint Perry, David Quissell, Mary Reyland, and Irina I Grichtchenko
Am J Physiol Cell Physiol. 2008. [MEDLINE Citation]

Interaction between protein kinase C and protein kinase A can modulate transmitter release at the rat neuromuscular synapse.
M M Santafe, N Garcia, M A Lanuza, M Tomas, and J Tomas
J Neurosci Res. 2008. [MEDLINE Citation]

Protein kinase C-dependent and independent signaling pathways regulate synaptic GluR1 and GluR4 AMPAR subunits during in vitro, classical conditioning.
Z Zheng and J Keifer
Neuroscience. 2008. [MEDLINE Citation]

Identification of a small molecule with synthetic lethality for K-ras and protein kinase C iota.
W Guo, S Wu, J Liu, and B Fang
Cancer Res. 2008; 68: 7403. [MEDLINE Citation]

[Effect of protein kinase C and calcium on the thrombin receptors activation]
Y Han, ZY Wang, Y Xie, W Zhang, L Dai, WH Shen, DP Wu, and CG Ruan
Zhonghua Xue Ye Xue Za Zhi. 2008; 29: 154. [MEDLINE Citation]

The diverse roles of protein kinase C in pancreatic beta-cell function.
TJ Biden, C Schmitz-Peiffer, JG Burchfield, E Gurisik, J Cantley, CJ Mitchell, and L Carpenter
Biochem Soc Trans. 2008; 36: 916. [MEDLINE Citation]

Cloning and characterization of a protein kinase C gene from the spruce budworm, Choristoneura fumiferana.
Guo-Xing Quan, Daniel Doucet, Tim Ladd, Peter J Krell, and Basil M Arif
Insect Biochem Mol Biol. 2008. [MEDLINE Citation]

Glutamate receptors as targets of protein kinase C in the pathophysiology and treatment of animal models of Mania.
Steven Szabo, Rodrigo Machado-Vieira, Peixiong Yuan, Yun Wang, Yanling Wei, Cynthia Falke, Chiara Cirelli, Giulio Tononi, Husseini K Manji, and Jing Du
Neuropharmacology. 2008. [MEDLINE Citation]

Identification, Characterization and Initial Hit-to-Lead Optimization of a Series of 4-Arylamino-3-Pyridinecarbonitrile as Protein Kinase C theta (PKCtheta) Inhibitors.
Derek C Cole, Magda Asselin, Agnes Brennan, Robert Czerwinski, John W Ellingboe, Lori Fitz, Rita Greco, Xinyi Huang, Diane Joseph-McCarthy, Michael F Kelly, Matthew Kirisits, Julie Lee, Yuanhong Li, Paul Morgan, Joseph R Stock, De?sire?e H H Tsao, Allan Wissner, Xiaoke Yang, and Divya Chaudhary
J Med Chem. 2008. [MEDLINE Citation]

Regulation of Neutral Sphingomyelinase-2 (nSMase2) by Tumor Necrosis Factor-alpha Involves Protein Kinase C-delta in Lung Epithelial Cells
Christopher J. Clarke, J. Michael Guthrie, and Yusuf A. Hannun
Mol. Pharmacol. 2008; 74:1022-1032.  [Abstract] [Full Text] [PDF]

Protein Kinase C delta Localizes to Secretory Lysosomes in CD8+ CTL and Directly Mediates TCR Signals Leading to Granule Exocytosis-Mediated Cytotoxicity
Jennifer S. Y. Ma, Tarik F. Haydar, and Sasa Radoja
J. Immunol. 2008; 181:4716-4722.  [Abstract] [Full Text] [PDF]

Protein Kinase C-theta Is Required for Efficient Positive Selection
Sharon Celeste Morley, K. Scott Weber, Henry Kao, and Paul M. Allen
J. Immunol. 2008; 181:4696-4708.  [Abstract] [Full Text] [PDF]

Protein Kinase C theta Regulates Stability of the Peripheral Adhesion Ring Junction and Contributes to the Sensitivity of Target Cell Lysis by CTL
Allison M. Beal, Nadia Anikeeva, Rajat Varma, Thomas O. Cameron, Philip J. Norris, Michael L. Dustin, and Yuri Sykulev
J. Immunol. 2008; 181:4815-4824.  [Abstract] [Full Text] [PDF]

PKC phosphorylation modulates PKA-dependent binding of the R domain to other domains of CFTR
Gage Seavilleklein, Noha Amer, Alexandra Evagelidis, Frederic Chappe, John Hanrahan, and Valerie Chappe
Am J Physiol Cell Physiol. published 17 September 2008, 10.1152/ajpcell.00034.2008  [Abstract] [PDF]

PKC theta selectively controls the adhesion-stimulating molecule Rap1
Thomas Letschka, Veronika Kollmann, Christa Pfeifhofer-Obermair, Christina Lutz-Nicoladoni, Gerald J Obermair, Friedrich Fresser, Michael Leitges, Natascha Hermann-Kleiter, Sandra Kaminski, and Gottfried Baier
Blood. published 16 September 2008, 10.1182/blood-2007-11-121111  [Abstract] [PDF]

Identification of a Small Molecule with Synthetic Lethality for K-Ras and Protein Kinase C Iota
Wei Guo, Shuhong Wu, Jinsong Liu, and Bingliang Fang
Cancer Res. 2008; 68:7403-7408.  [Abstract] [Full Text] [PDF]

Tauroursodeoxycholic acid exerts anticholestatic effects by a cooperative cPKC alpha -/PKA-dependent mechanism in rat liver
R Wimmer, S Hohenester, T Pusl, G U Denk, C Rust, and U Beuers
Gut. 2008; 57:1448-1454.  [Abstract] [Full Text] [PDF]

Aldose Reductase Regulates High Glucose-Induced Ectodomain Shedding of TNF-{alpha} via PKC-{delta} And TACE in Vascular Smooth Muscle Cells.
Aramati B M Reddy, Kota V Ramana, Sanjay Srivastava, Aruni Bhatnagar, and Satish K Srivastava
Endocrinology. 2008. [MEDLINE Citation]

Eukaryotic ribosomes host PKC activity.
Stefano Grosso, Viviana Volta, Marina Vietri, Chiara Gorrini, Pier Carlo Marchisio, and Stefano Biffo
Biochem Biophys Res Commun. 2008. [MEDLINE Citation]

Low-power laser irradiation inhibiting Abeta25-35-induced PC12 cell apoptosis via PKC activation.
L Zhang, D Xing, D Zhu, and Q Chen
Cell Physiol Biochem. 2008; 22: 215. [MEDLINE Citation]

Changes in intracellular Ca2+ levels induced by cytokines and P2 agonists differentially modulate proliferation or commitment with macrophage differentiation in murine hematopoietic cells.
Edgar J Paredes-Gamero, Carlos M M P Leon, Radovan Borojevic, Maria E M Oshiro, and Alice T Ferreira
J Biol Chem. 2008. [MEDLINE Citation]

Exploitation of protein kinase C: A useful target for cancer therapy.
Ashhar S Ali, Shadan Ali, Bassel F El-Rayes, Philip A Philip, and Fazlul H Sarkar
Cancer Treat Rev. 2008. [MEDLINE Citation]

Oxidative Stress Mediates Protein Kinase C Activation and Advanced Glycation End Product Formation in a Mesangial Cell Model of Diabetes and High Protein Diet.
Katherine R Tuttle, Robert J Anderberg, Sheryl K Cooney, and Rick L Meek
Am J Nephrol. 2008; 29: 171. [MEDLINE Citation]

Activation of protein kinase C enhances NMDA-induced currents in primary cultured cerebellar granule cells: Effect of temperature and NMDA NR2 subunit composition.
R Lisa Popp, Jason C Reneau, and B Jason Brotherton
Eur J Pharmacol. 2008. [MEDLINE Citation]

[Effects of lead exposure on protein kinase C and calmodulin expression in hippocampus and neurobehavioral function of baby rats]
FS Wang, ZH Liu, JS Zhang, and JR Di
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2008; 26: 139. [MEDLINE Citation]

Role of DAX-1 in PKA- and PKC-Mediated Regulation of the Steroidogenic Acute Regulatory Protein Expression in Mouse Leydig Tumor Cells: Mechanism of Action
Pulak R. Manna, Matthew T. Dyson, Youngah Jo, and Douglas M. Stocco
Endocrinology. published 11 September 2008, 10.1210/en.2008-0368  [Abstract]

NK cell activating receptors require PKC theta for sustained signaling, transcriptional activation and IFN-gamma secretion
Ilaria Tassi, Marina Cella, Rachel Presti, Angela Colucci, Susan Gilfillan, Dan R Littman, and Marco Colonna
Blood. published 10 September 2008, 10.1182/blood-2008-02-139527  [Abstract] [PDF]

Poststroke neuronal rescue and synaptogenesis mediated in vivo by protein kinase C in adult brains
Miao-Kun Sun, Jarin Hongpaisan, Thomas J. Nelson, and Daniel L. Alkon
PNAS. 2008; 105:13620-13625.  [Abstract] [Full Text] [PDF]

PKC eta directs induction of IRF-4 expression and Ig kappa gene rearrangement in pre-BCR signaling pathway
Akihisa Oda, Tomohiro Ono, Mutsumi Yamamoto, Ryo Goitsuka, and Daisuke Kitamura
Int. Immunol. published 9 September 2008, 10.1093/intimm/dxn101  [Abstract] [Full Text] [PDF]

Infarct limitation by a protein kinase G activator at reperfusion in rabbit hearts is dependent on sensitizing the heart to A2b agonists by protein kinase C
Atsushi Kuno, Nataliya V. Solenkova, Victoriya Solodushko, Turhan Dost, Yanping Liu, Xi-Ming Yang, Michael V. Cohen, and James M. Downey
Am J Physiol Heart Circ Physiol. 2008; 295:H1288-H1295.  [Abstract] [Full Text] [PDF]

The Protein Kinase C-Responsive Inhibitory Domain of CARD11 Functions in NF-kappa B Activation To Regulate the Association of Multiple Signaling Cofactors That Differentially Depend on Bcl10 and MALT1 for Association
Ryan R. McCully and Joel L. Pomerantz
Mol. Cell. Biol. 2008; 28:5668-5686.  [Abstract] [Full Text] [PDF]

Aldose Reductase Regulates High Glucose-Induced Ectodomain Shedding of TNF-alpha via PKC-delta And TACE in Vascular Smooth Muscle Cells
Aramati B.M. Reddy, Kota V. Ramana, Sanjay Srivastava, Aruni Bhatnagar, and Satish K. Srivastava
Endocrinology. published 4 September 2008, 10.1210/en.2008-0677  [Abstract]

Poststroke neuronal rescue and synaptogenesis mediated in vivo by protein kinase C in adult brains
Miao-Kun Sun, Jarin Hongpaisan, Thomas J. Nelson, and Daniel L. Alkon
PNAS. published 3 September 2008, 10.1073/pnas.0805952105  [Abstract] [PDF]

Delta protein kinase C interacts with the "d" subunit of the F1Fo ATPase in neonatal cardiac myocytes exposed to hypoxia or phorbol ester: Implications for F1Fo regulation.
Tiffany M Nguyen, Mourad Ogbi, and John A Johnson
J Biol Chem. 2008. [MEDLINE Citation]

Phosphorylation of farnesoid X receptor by protein kinase C promotes its transcriptional activity.
Romain Gineste, Audrey Sirvent, Rejane Paumelle, Stephane Helleboid, Alexis Aquilina, Raphael Darteil, Dean W Hum, Jean-Charles Fruchart, and Bart Staels
Mol Endocrinol. 2008. [MEDLINE Citation]

Gonadotropin-Releasing Hormone inhibits Pituitary Adenylyl Cyclase-Activating Polypeptide coupling to 3', 5'-Cyclic Adenosine-5'-Monophosphate pathway in L{beta}T2 gonadotrope cells through novel Protein Kinase C isoforms and phosphorylation of Pituitary Adenylyl Cyclase-Activating Polypeptide type I receptor.
Sigolene Lariviere, Ghislaine Garrel-Lazayres, Violaine Simon, Norihito Shintani, Akemichi Baba, Raymond Counis, and Joelle Cohen-Tannoudji
Endocrinology. 2008. [MEDLINE Citation]

Protein kinase C subtypes and retinal ischemic preconditioning.
John C Dreixler, Afzhal R Shaikh, Shanti K Shenoy, Yang Shen, and Steven Roth
Exp Eye Res. 2008. [MEDLINE Citation]

The protein kinase C phosphorylation site on GAP-43 differentially regulates information storage.
Matthew Holahan and Aryeh Routtenberg
Hippocampus. 2008. [MEDLINE Citation]

Activation of protein kinase C enhances NMDA-induced currents in primary cultured cerebellar granule cells: Effect of temperature and NMDA NR2 subunit composition.
R Lisa Popp, Jason C Reneau, and B Jason Brotherton
Eur J Pharmacol. 2008. [MEDLINE Citation]

Isoform-specific contribution of protein kinase C to prion processing.
Moustapha Alfa Cisse, Krystel Louis, Uschi Braun, Bernard Mari, Michael Leitges, Barbara E Slack, Abraham Fisher, Patrick Auberger, Frederic Checler, and Bruno Vincent
Mol Cell Neurosci. 2008. [MEDLINE Citation]

[Effects of lead exposure on protein kinase C and calmodulin expression in hippocampus and neurobehavioral function of baby rats.]
FS Wang, ZH Liu, JS Zhang, and JR DI
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2008; 26: 139. [MEDLINE Citation]

A mechanism underlying stimulation and inhibition of protein kinase C by lyso-PC: A role of membrane physical state.
Z Pan and J Chen
Sci China C Life Sci. 1998; 41: 584. [MEDLINE Citation]

The role of c-Jun in the regulation of PKC-mediated StAR expression and steroidogenesis in mouse Leydig cells.
Pulak Manna and Douglas Stocco
J Mol Endocrinol. 2008. [MEDLINE Citation]

Ectodomain cleavage of the EGF ligands HB-EGF, neuregulin1-{beta}, and TGF-{alpha} is specifically triggered by different stimuli and involves different PKC isoenzymes.
Andreas Herrlich, Eva Klinman, Jonathan Fu, Cameron Sadegh, and Harvey Lodish
FASEB J. 2008. [MEDLINE Citation]

Pkc-delta mediates von Willebrand factor secretion from endothelial cells in response to VEGF but not histamine.
O Lorenzi, M Frieden, P Villemin, M Fournier, M Foti, and U M Vischer
J Thromb Haemost. 2008. [MEDLINE Citation]

Evaluation of Renal Gene Expression of Protein Kinase C (PKC) Isoforms in Diabetic and Nondiabetic Proliferative Glomerular Diseases.
Salwa Ibrahim, Laila Rashed, and Sawsan Fadda
ScientificWorldJournal. 2008; 8: 835. [MEDLINE Citation]

The gi-coupled P2Y12 receptor regulates diacylglycerol-mediated signaling in human platelets.
Gianni F Guidetti, Paolo Lova, Bruno Bernardi, Francesca Campus, Gianluca Baldanzi, Andrea Graziani, Cesare Balduini, and Mauro Torti
J Biol Chem. 2008. [MEDLINE Citation]

ETHER-LINKED DIGLYCERIDES INHIBIT VASCULAR SMOOTH MUSCLE CELL GROWTH VIA DECREASED MAPK AND PI3K/AKT SIGNALING.
Kristy L Houck, Todd E Fox, Lakshman Sandirasegarane, and Mark Kester
Am J Physiol Heart Circ Physiol. 2008. [MEDLINE Citation]

Angiotensin II stimulates water and NaCl intake through separate cell signalling pathways.
Derek Daniels, Elizabeth G Mietlicki, Erica L Nowak, and Steven J Fluharty
Exp Physiol. 2008. [MEDLINE Citation]

Serotonin interferes with Ca(2+) and PKC signaling to reduce gonadotropin-releasing hormone-stimulated GH secretion in goldfish pituitary cells.
Yi Yu, Anderson O L Wong, and John P Chang
Gen Comp Endocrinol. 2008. [MEDLINE Citation]

Involvement of PKC in TPA-potentiated apoptosis induction during hemin-mediated erythroid differentiation in K562 cells.
Chih Chung Chou and Chen Ya Hsu
Naunyn Schmiedebergs Arch Pharmacol. 2008. [MEDLINE Citation]

Molecular targeting of the PKC-beta inhibitor enzastaurin (LY317615) in multiple myeloma involves a coordinated downregulation of MYC and IRF4 expression.
Donata Verdelli, Lucia Nobili, Katia Todoerti, Daniela Intini, Maria Cosenza, Monica Civallero, Jessika Bertacchini, Giorgio Lambertenghi Deliliers, Stefano Sacchi, Luigia Lombardi, and Antonino Neri
Hematol Oncol. 2008. [MEDLINE Citation]

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