August 2008

Ectodomain cleavage of the EGF ligands HB-EGF, neuregulin1-, and TGF- is specifically triggered by different stimuli and involves different PKC isoenzymes
Andreas Herrlich, Eva Klinman, Jonathan Fu, Cameron Sadegh, and Harvey Lodish
FASEB J. published 29 August 2008, 10.1096/fj.08-113852  [Abstract]

The role of c-Jun in the regulation of PKC-mediated StAR expression and steroidogenesis in mouse Leydig cells
Pulak Manna and Douglas Stocco
J. Mol. Endocrinol. published 28 August 2008, 10.1677/JME-08-0077  [Abstract] [PDF]

Phosphorylation of farnesoid X receptor by protein kinase C promotes its transcriptional activity
Romain Gineste, Audrey Sirvent, Réjane Paumelle, Stéphane Helleboid, Alexis Aquilina, Raphaël Darteil, Dean W. Hum, Jean-Charles Fruchart, and Bart Staels
Mol. Endocrinol. published 28 August 2008, 10.1210/me.2008-0092  [Abstract]

Gonadotropin-Releasing Hormone inhibits Pituitary Adenylyl Cyclase-Activating Polypeptide coupling to 3', 5'-Cyclic Adenosine-5'-Monophosphate pathway in LT2 gonadotrope cells through novel Protein Kinase C isoforms and phosphorylation of Pituitary Adenylyl Cyclase-Activating Polypeptide type I receptor
Sigolène LARIVIÈRE, Ghislaine GARREL-LAZAYRES, Violaine SIMON, Norihito SHINTANI, Akemichi BABA, Raymond COUNIS, and Joëlle COHEN-TANNOUDJI
Endocrinology. published 28 August 2008, 10.1210/en.2008-0504  [Abstract]

PKCbetaII augments NF-kappaB-dependent transcription at the CCL11 promoter via p300/CBP-associated factor recruitment and histone H4 acetylation.
DL Clarke, A Sutcliffe, K Deacon, D Bradbury, L Corbett, and AJ Knox
J Immunol. 2008; 181: 3503. [MEDLINE Citation]

Delta protein kinase C interacts with the "d" subunit of the F₁Fo ATPase in neonatal cardiac myocytes exposed to hypoxia or phorbol ester: Implications for F₁Fo regulation
Tiffany M. Nguyen, Mourad Ogbi, and John A. Johnson
J. Biol. Chem. published 25 August 2008, 10.1074/jbc.M801642200  [Abstract] [PDF]

CalDAG-GEFI and protein kinase C represent alternative pathways leading to activation of integrin IIbβ3 in platelets
Stephen M. Cifuni, Denisa D. Wagner, and Wolfgang Bergmeier
Blood. 2008; 112:1696-1703.  [Abstract] [Full Text] [PDF]

Protein Kinase C- Induces Caveolin-Dependent Internalization of Vascular Adenosine 5'-Triphosphate–Sensitive K⁺ Channels
Jundong Jiao, Vivek Garg, Baofeng Yang, Terry S. Elton, and Keli Hu
Hypertension. 2008; 52:499-506.  [Abstract] [Full Text] [PDF]

Rac regulates the interaction of fascin with protein kinase C in cell migration
Maddy Parsons and Josephine C. Adams
J. Cell Sci. 2008; 121:2805-2813.  [Abstract] [Full Text] [PDF]

Knock-In Mice Lacking the PDZ-Ligand Motif of mGluR7a Show Impaired PKC-Dependent Autoinhibition of Glutamate Release, Spatial Working Memory Deficits, and Increased Susceptibility to Pentylenetetrazol
Chuan-Sheng Zhang, Federica Bertaso, Volker Eulenburg, Mireille Lerner-Natoli, Greta Ann Herin, Liane Bauer, Joel Bockaert, Laurent Fagni, Heinrich Betz, and Astrid Scheschonka
J. Neurosci. 2008; 28:8604-8614.  [Abstract] [Full Text] [PDF]

Novel PKC signaling is required for LPS-induced soluble Flt-1 expression in macrophages
Ming-Cheng Lee, Shu-Chen Wei, Jyy-Jih Tsai-Wu, C. H. Herbert Wu, and Po-Nien Tsao
J. Leukoc. Biol. 2008; 84:835-841.  [Abstract] [Full Text] [PDF]

The Major Chemical-detoxifying System of UDP-glucuronosyltransferases Requires Regulated Phosphorylation Supported by Protein Kinase C
Nikhil K. Basu, Labanyamoy Kole, Mousumi Basu, Kushal Chakraborty, Partha S. Mitra, and Ida S. Owens
J. Biol. Chem. 2008; 283:23048-23061.  [Abstract] [Full Text] [PDF]

Neph-Nephrin Proteins Bind the Par3-Par6-Atypical Protein Kinase C (aPKC) Complex to Regulate Podocyte Cell Polarity
Björn Hartleben, Heiko Schweizer, Pauline Lübben, Malte P. Bartram, Clemens C. Möller, Ronja Herr, Changli Wei, Elke Neumann-Haefelin, Bernhard Schermer, Hanswalter Zentgraf, Dontscho Kerjaschki, Jochen Reiser, Gerd Walz, Thomas Benzing, and Tobias B. Huber
J. Biol. Chem. 2008; 283:23033-23038.  [Abstract] [Full Text] [PDF]

Phorbol Esters Modulate Spontaneous and Ca²⁺-Evoked Transmitter Release via Acting on Both Munc13 and Protein Kinase C
Xuelin Lou, Natalya Korogod, Nils Brose, and Ralf Schneggenburger
J. Neurosci. 2008; 28:8257-8267.  [Abstract] [Full Text] [PDF]

Protein kinase C.
Alexandra C Newton
IUBMB Life. 2008. [MEDLINE Citation]

Protein kinase C modulates synaptic vesicle acidification in a ribbon type nerve terminal in the retina.
Bento J Abreu, Maila Guimaraes, Livia C Uliana, Jozsef Vigh, Henrique von Gersdorff, Marco A Prado, and Cristina Guatimosim
Neurochem Int. 2008. [MEDLINE Citation]

A protein kinase C activity localized to neuropeptide Y-like neurons mediates ethanol intoxication in Drosophila melanogaster.
J Chen, Y Zhang, and P Shen
Neuroscience. 2008. [MEDLINE Citation]

Activity of protein kinase C is important for 3alpha,5alpha-THP's actions at dopamine type 1-like and/or GABA(A) receptors in the ventral tegmental area for lordosis of rats.
Cheryl A Frye and Alicia A Walf
Brain Res Bull. 2008. [MEDLINE Citation]

The life and death of protein kinase C.
CM Gould and AC Newton
Curr Drug Targets. 2008; 9: 614. [MEDLINE Citation]

[Chemoattractant-induced reactive oxigen species production in human neutrophils--role of protein kinase c isoforms]
O Bredetean, AD Ciochina, and OC Mungiu
Rev Med Chir Soc Med Nat Iasi. 2008; 112: 258. [MEDLINE Citation]

Potential role of PKC inhibitors in the treatment of hematological malignancies.
C Mischiati, E Melloni, F Corallini, D Milani, C Bergamini, and M Vaccarezza
Curr Pharm Des. 2008; 14: 2075. [MEDLINE Citation]

PKC-dependent extracellular signal-regulated kinase 1/2 pathway is involved in the inhibition of Ib on AngiotensinII-induced proliferation of vascular smooth muscle cells.
Yu Wang, Tianhua Yan, Qiujuan Wang, Wei Wang, Jinyi Xu, Xiaoming Wu, and Hui Ji
Biochem Biophys Res Commun. 2008. [MEDLINE Citation]

The PKC inhibitor AEB071 may be a therapeutic option for psoriasis.
Hans Skvara, Markus Dawid, Elise Kleyn, Barbara Wolff, Josef G Meingassner, Hilary Knight, Thomas Dumortier, Tamara Kopp, Nasanin Fallahi, Georg Stary, Christoph Burkhart, Olivier Grenet, Juergen Wagner, Youssef Hijazi, Randall E Morris, Claire McGeown, Christiane Rordorf, Christopher E M Griffiths, Georg Stingl, and Thomas Jung
J Clin Invest. 2008. [MEDLINE Citation]

HIV-1 Tat protein induces TNF-alpha and IL-10 production by human macrophages: Differential implication of PKC-betaII and -delta isozymes and MAP kinases ERK1/2 and p38.
Kaoutar Leghmari, Xavier Contreras, Corinne Moureau, and Elmostafa Bahraoui
Cell Immunol. 2008. [MEDLINE Citation]

The Role of P38 MAPK and PKC in BLP Induced TNF-alpha Release, Apoptosis and NFkappaB Activation in THP-1 Monocyte Cells.
Adrian W O'Sullivan, Jiang H Wang, and Henry P Redmond
J Surg Res. 2008. [MEDLINE Citation]

Endosomal lipid accumulation in NPC1 leads to inhibition of PKC, hypophosphorylation of vimentin and Rab9 entrapment.
Marc Walter, Fannie W Chen, Farshad Tamari, Rong Wang, and Yiannis A Ioannou
Biol Cell. 2008. [MEDLINE Citation]

Tyrosine Phosphorylation Modifies Protein Kinase C -dependent Phosphorylation of Cardiac Troponin I
Marius P. Sumandea, Vitalyi O. Rybin, Aaron C. Hinken, Chaojian Wang, Tomoyoshi Kobayashi, Erin Harleton, Gail Sievert, C. William Balke, Steven J. Feinmark, R. John Solaro, and Susan F. Steinberg
J. Biol. Chem. 2008; 283:22680-22689.  [Abstract] [Full Text] [PDF]

Intramitochondrial signaling: interactions among mitoK_ATP, PKC, ROS, and MPT
Alexandre D. T. Costa and Keith D. Garlid
Am J Physiol Heart Circ Physiol. 2008; 295:H874-H882.  [Abstract] [Full Text] [PDF]

Innocuous, Not Noxious, Input Activates PKC Interneurons of the Spinal Dorsal Horn via Myelinated Afferent Fibers
Simona Neumann, Joao M. Braz, Kate Skinner, Ida J. Llewellyn-Smith, and Allan I. Basbaum
J. Neurosci. 2008; 28:7936-7944.  [Abstract] [Full Text] [PDF]

Myocardial Hsp70 phosphorylation and PKC-mediated cardioprotection following exercise.
C W James Melling, David B Thorp, Kevin J Milne, and Earl G Noble
Cell Stress Chaperones. 2008. [MEDLINE Citation]

Protein Kinase C-{epsilon} Induces Caveolin-Dependent Internalization of Vascular Adenosine 5'-Triphosphate-Sensitive K+ Channels.
Jundong Jiao, Vivek Garg, Baofeng Yang, Terry S Elton, and Keli Hu
Hypertension. 2008. [MEDLINE Citation]

Protein Kinase C Modulates Inactivation of Kv3.3 Channels
Rooma Desai, Jack Kronengold, Jianfeng Mei, Stuart A. Forman, and Leonard K. Kaczmarek
J. Biol. Chem. 2008; 283:22283-22294.  [Abstract] [Full Text] [PDF]

Rosiglitazone improves aortic arginine transport, through inhibition of PKC, in uremic rats
Merav Ingbir, Idit F. Schwartz, Alexander Shtabsky, Irina Filip, Ran Reshef, Tamara Chernichovski, Nomi Levin-Iaina, Uri Rozovski, Yoram Levo, and Doron Schwartz
Am J Physiol Renal Physiol. 2008; 295:F471-F477.  [Abstract] [Full Text] [PDF]

PKC Acts Upstream of SPAK in the Activation of NKCC1 by Hyperosmotic Stress in Human Airway Epithelial Cells
Laura Smith, Nicole Smallwood, Amnon Altman, and Carole M. Liedtke
J. Biol. Chem. 2008; 283:22147-22156.  [Abstract] [Full Text] [PDF]

Phosphatidylinositol 3-kinase-dependent insulin regulation of long-chain fatty acid (LCFA) metabolism in L6 muscle cells: involvement of atypical protein kinase C- in LCFA uptake but not oxidation
Karen R Kelly, Chin K Sung, Marcia J Abbott, and Lorraine P Turcotte
J. Endocrinol. 2008; 198:375-384.  [Abstract] [Full Text] [PDF]