June 2007

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Differential phosphorylation of NG2 proteoglycan by ERK and PKC{alpha} helps balance cell proliferation and migration
Irwan T. Makagiansar, Scott Williams, Tomas Mustelin, and William B. Stallcup
published 25 June 2007, 10.1083/jcb.200612084  [Full Text] [PDF]

Decrease in PIP2-channel interactions is the final common mechanism involved in PKC- and arachidonic acid-mediated inhibitions of GABAB-activated K+ current.
Jong-Woo Sohn, Ajin Lim, Suk-Ho Lee, and Won-Kyung Ho
J Physiol. 2007. [MEDLINE Citation]

Activation of extrasynaptic NMDA receptors induces a PKC-dependent switch in AMPA receptor subtypes in mouse cerebellar stellate cells.
Lu Sun and Siqiong June Liu
J Physiol. 2007. [MEDLINE Citation]

Muscarinic M2 and M1receptors reduce GABA release by Ca2+-channels modulation through activation of PI3K/Ca2+-independent- and PLC/ Ca2+-dependent-PKC.
Humberto Salgado, Timothy Bellay, Justin Andrew Nichols, Mitali Bose, Laura M Martinolich, Linda Perrotti, and Marco Atzori
J Neurophysiol. 2007. [MEDLINE Citation]

Regulation of {alpha}1-adrenoceptor-mediated contractions of the uterine artery by PKC: role of the thick and thin filament regulatory pathways.
Hongying Zhang and Lubo Zhang
J Pharmacol Exp Ther. 2007. [MEDLINE Citation]

PKCepsilon and Src control PKCdelta activation loop phosphorylation in cardiomyocytes.
Vitalyi O Rybin, Jianfen Guo, Zoya Gertsberg, Hasnae Elouardighi, and Susan F Steinberg
J Biol Chem. 2007. [MEDLINE Citation]

Neuroprotective Effect of PKC{delta} Inhibitor Rottlerin in Cell Culture and Animal Models of Parkinson's Disease.
Danhui Zhang, Vellareddy Anantharam, Arthi Kanthasamy, and Anumantha G Kanthasamy
J Pharmacol Exp Ther. 2007. [MEDLINE Citation]

Ginsenosides promote proliferation of chicken primordial germ cells via PKC-involved activation of NF-kappaB.
Chutian Ge, Caiqiao Zhang, Jian Ye, Xinyan Tang, and Yanqun Wu
Cell Biol Int. 2007. [MEDLINE Citation]

Insulin Causes Renal Dopamine D1 Receptor Desensitization via GRK2-mediated Receptor Phosphorylation Involving Phosphatidylinositol 3-Kinase and Protein kinase C.
Anees Ahmad Banday, Fatima Rizwan Fazili, and Mustafa F Lokhandwala
Am J Physiol Renal Physiol. 2007. [MEDLINE Citation]

Actions of Epidermal Growth Factor Receptor/Mitogen-Activated Protein Kinase and Protein Kinase C Signaling in Granulosa Cells from Gallus gallus Are Dependent upon Stage of Differentiation

Dori C. Woods, Morgan J. Haugen, and A.L. Johnson (1 July 2007)
Biol Reprod 77 (1), 61. [DOI: 10.1095/biolreprod.106.059394]
 |  Abstract »  |  Full Text »  |  PDF »
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Regulation of {alpha}1-adrenoceptor-mediated contractions of the uterine artery by PKC: role of the thick and thin filament regulatory pathways.
Hongying Zhang and Lubo Zhang
J Pharmacol Exp Ther. 2007. [MEDLINE Citation]

Augmented Protein Kinase C-{alpha}-Induced Myofilament Protein Phosphorylation Contributes to Myofilament Dysfunction in Experimental Congestive Heart Failure.
Rashad J Belin, Marius P Sumandea, Edward J Allen, Kelly Schoenfelt, Helen Wang, R John Solaro, and Pieter P de Tombe
Circ Res. 2007. [MEDLINE Citation]

Protein kinase C{delta}-dependent and -independent signaling in genotoxic response to treatment of desferroxamine, a hypoxia-mimetic agent.
C Clavijo, JL Chen, KJ Kim, ME Reyland, and DK Ann
Am J Physiol Cell Physiol. 2007; 292: C2150. [MEDLINE Citation]

Neuroprotective Effect of PKC{delta} Inhibitor Rottlerin in Cell Culture and Animal Models of Parkinson's Disease.
Danhui Zhang, Vellareddy Anantharam, Arthi Kanthasamy, and Anumantha G Kanthasamy
J Pharmacol Exp Ther. 2007. [MEDLINE Citation]

EXPRESSION OF SPECIFIC PROTEIN KINASE C (PKC) ISOFORMS AND LIGAND-SPECIFIC ACTIVATION OF PKCalpha IN LATE GESTATION FETAL LUNG.
D Villanueva-Garcia, KT Wang, HC Nielsen, and SM Ramadurai
Exp Lung Res. 2007; 33: 185. [MEDLINE Citation]

Insulin Causes Renal Dopamine D1 Receptor Desensitization via GRK2-mediated Receptor Phosphorylation Involving Phosphatidylinositol 3-Kinase and Protein kinase C.
Anees Ahmad Banday, Fatima Rizwan Fazili, and Mustafa F Lokhandwala
Am J Physiol Renal Physiol. 2007. [MEDLINE Citation]

Induction of apoptosis is driven by nulcear retention of PKCdelta.
Tracie A Devries-Seimon, Angela M Ohm, Michael J Humphries, and Mary E Reyland
J Biol Chem. 2007. [MEDLINE Citation]

PKCepsilon and Src control PKCdelta activation loop phosphorylation in cardiomyocytes
Vitalyi O. Rybin, Jianfen Guo, Zoya Gertsberg, Hasnae Elouardighi, and Susan F. Steinberg
published 14 June 2007, 10.1074/jbc.M701676200  [Abstract] [PDF]

Induction of apoptosis is driven by nulcear retention of PKCdelta
Tracie A. DeVries-Seimon, Angela M. Ohm, Michael J. Humphries, and Mary E. Reyland
published 11 June 2007, 10.1074/jbc.M703661200  [Abstract] [PDF]

Protein kinase C{delta}-dependent and -independent signaling in genotoxic response to treatment of desferroxamine, a hypoxia-mimetic agent

Carlos Clavijo, Jo-Lin Chen, Kwang-Jin Kim, Mary E. Reyland, and David K. Ann (1 June 2007)
Am J Physiol Cell Physiol 292 (6), C2150. [DOI: 10.1152/ajpcell.00425.2006]
 |  Abstract »  |  Full Text »  |  PDF »
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Protein kinase C regulates vascular myogenic tone through activation of TRPM4

Scott Earley, Stephen V. Straub, and Joseph E. Brayden (1 June 2007)
Am J Physiol Heart Circ Physiol 292 (6), H2613. [DOI: 10.1152/ajpheart.01286.2006]
 |  Abstract »  |  Full Text »  |  PDF »
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Activation of classical protein kinase C decreases transport via systems y+ and y+L

Alexander Rotmann, Alexandra Simon, Ursula Martiné, Alice Habermeier, and Ellen I. Closs (1 June 2007)
Am J Physiol Cell Physiol 292 (6), C2259. [DOI: 10.1152/ajpcell.00323.2006]
 |  Abstract »  |  Full Text »  |  PDF »  |  Supplemental Figures »

Mechanism of diacylglycerol-induced membrane targeting and activation of protein kinase Ctheta.
Heather R Melowic, Robert V Stahelin, Nichole R Blatner, Wen Tian, Keitaro Hayashi, Amnon Altman, and Wonhwa Cho
J Biol Chem. 2007. [MEDLINE Citation]

Claudin-1 overexpression in melanoma is regulated by PKC and contributes to melanoma cell motility.
PD Leotlela, MS Wade, PH Duray, MJ Rhode, HF Brown, DT Rosenthal, SK Dissanayake, R Earley, FE Indig, BJ Nickoloff, DD Taub, OP Kallioniemi, P Meltzer, PJ Morin, and AT Weeraratna
Oncogene. 2007; 26: 3846. [MEDLINE Citation]

Protein Kinase C{delta} Regulates Antigen Receptor-Induced Lytic Granule Polarization in Mouse CD8+ CTL.
JS Ma, N Monu, DT Shen, I Mecklenbrauker, N Radoja, TF Haydar, M Leitges, AB Frey, S Vukmanovic, and S Radoja
J Immunol. 2007; 178: 7814. [MEDLINE Citation]

Roles of Protein Kinase C and Actin Binding Protein 280 in the Regulation of Intracellular Trafficking of Dopamine D3 Receptor.
Eun-Young Cho, Dong-Im Cho, Jae H Park, Hitoshi Kurose, Marc G Caron, and Kyeong-Man Kim
Mol Endocrinol. 2007. [MEDLINE Citation]

Involvement of integrin-induced activation of protein kinase C in the formation of adherens junctions.
M Ozaki, H Ogita, and Y Takai
Genes Cells. 2007; 12: 651. [MEDLINE Citation]

Ethanol and fish oil induce NFkappaB transactivation of the collagen alpha2(I) promoter through lipid peroxidation-driven activation of the PKC-PI3K-Akt pathway.
N Nieto
Hepatology. 2007; 45: 1433. [MEDLINE Citation]

Mechanism of diacylglycerol-induced membrane targeting and activation of protein kinase Ctheta
Heather R. Melowic, Robert V. Stahelin, Nichole R. Blatner, Wen Tian, Keitaro Hayashi, Amnon Altman, and Wonhwa Cho
published 4 June 2007, 10.1074/jbc.M700119200  [Abstract] [PDF]

The Wnt5A/Protein Kinase C Pathway Mediates Motility in Melanoma Cells via the Inhibition of Metastasis Suppressors and Initiation of an Epithelial to Mesenchymal Transition
Samudra K. Dissanayake, Michael Wade, Carrie E. Johnson, Michael P. O'Connell, Poloko D. Leotlela, Amanda D. French, Kavita V. Shah, Kyle J. Hewitt, Devin T. Rosenthal, Fred E. Indig, Yuan Jiang, Brian J. Nickoloff, Dennis D. Taub, Jeffrey M. Trent, Randall T. Moon, Michael Bittner, and Ashani T. Weeraratna
J. Biol. Chem. 2007; 282:17259-17271.  [Abstract] [Full Text] [PDF]

Dietary polyunsaturated Fatty acids alter myocardial protein kinase C expression and affect cardioprotection induced by chronic hypoxia.
M Hlavackova, J Neckar, J Jezkova, P Balkova, B Stankova, O Novakova, F Kolar, and F Novak
Exp Biol Med (Maywood). 2007; 232: 823. [MEDLINE Citation]

Claudin-1 overexpression in melanoma is regulated by PKC and contributes to melanoma cell motility.
PD Leotlela, MS Wade, PH Duray, MJ Rhode, HF Brown, DT Rosenthal, SK Dissanayake, R Earley, FE Indig, BJ Nickoloff, DD Taub, OP Kallioniemi, P Meltzer, PJ Morin, and AT Weeraratna
Oncogene. 2007; 26: 3846. [MEDLINE Citation]

Roles of Protein Kinase C and Actin Binding Protein 280 in the Regulation of Intracellular Trafficking of Dopamine D3 Receptor.
Eun-Young Cho, Dong-Im Cho, Jae H Park, Hitoshi Kurose, Marc G Caron, and Kyeong-Man Kim
Mol Endocrinol. 2007. [MEDLINE Citation]

Ethanol and fish oil induce NFkappaB transactivation of the collagen alpha2(I) promoter through lipid peroxidation-driven activation of the PKC-PI3K-Akt pathway.
Natalia Nieto
Hepatology. 2007; 45: 1433. [MEDLINE Citation]

Protein Kinase C- alpha/betaII, delta, and zeta/lambda involvement in ethanol-induced MAPK expression in vascular smooth muscle cells.
AL Johnson, GD Goode, C Mtshali, EL Myles, and B Washington
Cell Mol Biol (Noisy-le-grand). 2007; 53: 38. [MEDLINE Citation]

Phosphorylation of Ser166 in RGS5 by protein kinase C causes loss of RGS function.
Kayoko Moroi, Mariko Nishiyama, Shin-Ichirou Kawabata, Hideaki Ichiba, Takehiko Yajima, and Sadao Kimura
Life Sci. 2007. [MEDLINE Citation]

Involvement of integrin-induced activation of protein kinase C in the formation of adherens junctions.
M Ozaki, H Ogita, and Y Takai
Genes Cells. 2007; 12: 651. [MEDLINE Citation]

 

Dysregulated intracellular signaling impairs CTGF-stimulated responses in human mesangial cells exposed to high extracellular glucose

Fiona Furlong, John Crean, Laura Thornton, Ronan O'Leary, Madeline Murphy, and Finian Martin (1 June 2007)
Am J Physiol Renal Physiol 292 (6), F1691. [DOI: 10.1152/ajprenal.00342.2006]
 |  Abstract »  |  Full Text »  |  PDF »  |  Supplemental Figure »
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PKC and polyamine modulation of GluR2-deficient AMPA receptors in immature neocortical pyramidal neurons of the rat

Jieun Shin, Fran Shen, and John Huguenard (1 June 2007)
J. Physiol. 581 (2), 679. [DOI: 10.1113/jphysiol.2007.130963]
 |  Abstract »  |  Full Text »  |  PDF »
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Potentiation of glutamatergic synaptic transmission by protein kinase C-mediated sensitization of TRPV1 at the first sensory synapse

Parul Sikand and Louis S. Premkumar (1 June 2007)
J. Physiol. 581 (2), 631. [DOI: 10.1113/jphysiol.2006.118620]
 |  Abstract »  |  Full Text »  |  PDF »

Neogenin-RGMa Signaling at the Growth Cone Is Bone Morphogenetic Protein-independent and Involves RhoA, ROCK, and PKC
Sabine Conrad, Harald Genth, Fred Hofmann, Ingo Just, and Thomas Skutella
J. Biol. Chem. 2007; 282:16423-16433.  [Abstract] [Full Text] [PDF]

Protein Kinase C{delta} Is Activated by Shiga Toxin and Regulates Its Transport
Maria L. Torgersen, Sébastien Wälchli, Stine Grimmer, Sigrid S. Skånland, and Kirsten Sandvig
J. Biol. Chem. 2007; 282:16317-16328.  [Abstract] [Full Text] [PDF]

The Wnt5A/Protein Kinase C Pathway Mediates Motility in Melanoma Cells via the Inhibition of Metastasis Suppressors and Initiation of an Epithelial to Mesenchymal Transition
Samudra K. Dissanayake, Michael Wade, Carrie E. Johnson, Michael P. O'Connell, Poloko D. Leotlela, Amanda D. French, Kavita V. Shah, Kyle J. Hewitt, Devin T. Rosenthal, Fred E. Indig, Yuan Jiang, Brian J. Nickoloff, Dennis D. Taub, Jeffrey M. Trent, Randall T. Moon, Michael Bittner, and Ashani T. Weeraratna
J. Biol. Chem. 2007; 282:17259-17271.  [Abstract] [Full Text] [PDF]