|
Substrates |
Year |
Title |
Web link |
|
14-3-3gamma |
1999 |
14-3-3Gamma interacts with and is phosphorylated by multiple protein
kinase C isoforms in PDGF-stimulated human vascular smooth muscle cells |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10433554 |
|
5-HT2A receptors |
2002 |
Internalization and recycling of 5-HT2A receptors activated by serotonin
and protein kinase C-mediated mechanisms |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12388782 |
|
Adducin |
1998 |
Adducin is an in vivo substrate for protein kinase C: phosphorylation in
the MARCKS-related domain inhibits activity in promoting spectrin-actin
complexes and occurs in many cells, including dendritic spines of
neurons |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9679146 |
|
Apoprotein A-1 |
1991 |
Apoprotein A-1 is a cofactor independent substrate of protein kinase C |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1909124 |
|
CAK |
2002 |
Human glioma PKC-iota and PKC-betaII phosphorylate cyclin-dependent
kinase activating kinase during the cell cycle |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11856176 |
|
Caldesmon77, Vimentin |
1992 |
Protein kinase C phosphorylates caldesmon77 and vimentin and enhances
albumin permeability across cultured bovine pulmonary artery endothelial
cell monolayers |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1522136 |
|
CaM-kinase |
1993 |
Ca2+/calmodulin-dependent protein kinase II is phosphorylated by protein
kinase C in vitro |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8384482 |
|
CD34 antigen |
1990 |
Activated protein kinase C directly phosphorylates the CD34 antigen on
hematopoietic cells |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1283964 |
|
CD34 antigen |
1992 |
Activated protein kinase C directly phosphorylates the CD34 antigen in
acute lymphoblastic leukemia cells |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1694174 |
|
CD8 alpha |
1990 |
Murine T-cell differentiation antigen CD8 is a direct substrate of
protein kinase C |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2115328 |
|
Centaurin-alpha(1) |
2003 |
Centaurin-alpha(1) associates with and is phosphorylated by isoforms of
protein kinase C |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12893243 |
|
Choline acetyltransferase (ChAT) |
2004 |
Protein kinase C isoforms differentially phosphorylate human choline
acetyltransferase regulating its catalytic activity |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15381704 |
|
chromatin-associated proteins |
1992 |
Importance of substrate conformation in the phosphorylation of
chromatin-associated proteins by exogenous protein kinase C |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1616821 |
|
clone 72 |
1999 |
Developmental expression of the protein kinase C substrate/binding
protein (clone 72/SSeCKS) in rat testis identification as a scaffolding
protein containing an A-kinase-anchoring domain which is expressed
during late-stage spermatogenesis |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10469144 |
|
Cytokeratins 8 and18 (CK8, CK18) |
1992 |
PKC epsilon-related kinase associates with and phosphorylates
cytokeratin 8 and 18 |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1374067 |
|
DAG kinase |
1993 |
Diacylglycerol kinase is phosphorylated in vivo upon stimulation of the
epidermal growth factor receptor and serine/threonine kinases, including
protein kinase C-epsilon |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7679574 |
|
DAG kinase (DGK) zeta |
2003 |
Protein kinase C alpha phosphorylates and negatively regulates
diacylglycerol kinase zeta |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12890670 |
|
Deoxyhypusine synthase |
2002 |
Deoxyhypusine synthase is phosphorylated by protein kinase C in vivo as
well as in vitro |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12526092 |
|
DNA topoisomerase I |
1989 |
Protein kinase C phosphorylates DNA topoisomerase I |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2557245 |
|
DNA topoisomerase I |
2003 |
Pea DNA topoisomerase I is phosphorylated and stimulated by casein
kinase 2 and protein kinase C |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12913165 |
|
EBV membrane receptor (CR2) |
1993 |
EBV membrane receptor (CR2) is phosphorylated by protein kinase C (PKC)
in the early stages of virus entry into lymphoblastoid cells line (Raji) |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7694579 |
|
EWS |
1997 |
The prooncoprotein EWS binds calmodulin and is phosphorylated by protein
kinase C through an IQ domain |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9341188 |
|
Filamin A |
2003 |
The F-actin cross-linking and focal adhesion protein filamin A is a
ligand and in vivo substrate for protein kinase C alpha |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12704190 |
|
FMIP |
2004 |
The M-CSF receptor substrate and interacting protein FMIP is governed in
its subcellular localization by protein kinase C-mediated
phosphorylation, and thereby potentiates M-CSF-mediated differentiation |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15221008 |
|
FOS |
1991 |
Fos is phosphorylated by p34cdc2, cAMP-dependent protein kinase and
protein kinase C at multiple sites clustered within regulatory regions |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1766667 |
|
GABA(A) receptor beta |
2002 |
Receptor for activated C kinase-1 facilitates protein kinase C-dependent
phosphorylation and functional modulation of GABA(A) receptors with the
activation of G-protein-coupled receptors |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12151513 |
|
GABAA-R |
1993 |
Ca2+/calmodulin-dependent protein kinase II and protein kinase C
phosphorylate a synthetic peptide corresponding to a sequence that is
specific for the gamma 2L subunit of the GABAA receptor |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8390566 |
|
GABAA-R |
1993 |
Phosphorylation of the GABAA receptor by cAMP-dependent protein kinase
and by protein kinase C: analysis of the substrate domain |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8385279 |
|
GAP |
1993 |
Protein kinase C forms a complex with and phosphorylates the GTPase
activating protein GAP: phosphorylation by PKC is dependent on tyrosine
phosphorylation of GAP and/or a GAP-associated protein |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7687440 |
|
GAP-43 |
1995 |
Protein kinase C substrates in corneal epithelium during wound healing:
the phosphorylation of growth associated protein-43 (GAP-43) |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8549686 |
|
GBPI |
2004 |
GBPI, a novel gastrointestinal- and brain-specific PP1-inhibitory
protein, is activated by PKC and inactivated by PKA |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12974676 |
|
Glutamate receptor 5a (mGluR5a) |
2004 |
Isoform-specific phosphorylation of metabotropic glutamate receptor 5 by
protein kinase C (PKC) blocks Ca2+ oscillation and oscillatory
translocation of Ca2+-dependent PKC |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14561742 |
|
GMF |
1997 |
Protein kinase A (PKA)- and protein kinase C-phosphorylated glia
maturation factor promotes the catalytic activity of PKA |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9030586 |
|
HCV(1487-1500) |
2000 |
A synthetic peptide derived from the non-structural protein 3 of
hepatitis C virus serves as a specific substrate for PKC |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10722046 |
|
Heat shock protein 25 |
2005 |
HSP25 inhibits protein kinase C delta-mediated cell death through direct
interaction |
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15731106 |
|
Heat shock protein 27 |
2007 |
Inhibition of heat shock protein 27-mediated resistance to DNA damaging
agents by a novel PKC delta-V5 heptapeptide |
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17616692 |
|
Heat-shock protein-25/28 |
1998 |
Heat-shock protein-25/27 phosphorylation by the delta isoform of protein
kinase C |
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9620873 |
|
Hematoxylin-stainable protein (HSP) |
1991 |
Identification of hematoxylin-stainable protein in epidermal
keratohyalin granules as phosphorylated cystatin alpha by protein kinase
C |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1715284 |
|
Heme-modified CYP3A4 |
2001 |
Phosphorylation of native and heme-modified CYP3A4 by protein kinase C:
a mass spectrometric characterization of the phosphorylated peptides. |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11560479 |
|
Hepatitis B virus-X protein |
2001 |
Phosphorylation of purified recombinant hepatitis B virus-X protein by
mitogen-activated protein kinase and protein kinase C in vitro. |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11377708 |
|
hnRNPA1 |
1995 |
Identification of heterogeneous ribonucleoprotein A1 as a novel
substrate for protein kinase C zeta |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7541049 |
|
IP(3)R |
2004 |
Regulation of the phosphorylation of the inositol 1,4,5-trisphosphate
receptor by protein kinase C |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15184066 |
|
IRAK |
2004 |
Regulation of interleukin receptor-associated kinase (IRAK)
phosphorylation and signaling by iota protein kinase C |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14684752 |
|
IRAP |
2002 |
Protein kinase C-zeta phosphorylates insulin-responsive aminopeptidase
in vitro at Ser-80 and Ser-91 |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12061804 |
|
IRS-1 |
2001 |
Protein kinase C-zeta phosphorylates insulin receptor substrate-1 and
impairs its ability to activate phosphatidylinositol 3-kinase in
response to insulin. |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11063744 |
|
IRS-1 |
2004 |
In vitro phosphorylation of insulin receptor substrate 1 by protein
kinase C-zeta: functional analysis and identification of novel
phosphorylation sites |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15134463 |
|
IRS-1 |
2004 |
Protein kinase C (PKC) beta modulates serine phosphorylation of insulin
receptor substrate-1 (IRS-1)--effect of overexpression of PKCbeta on
insulin signal transduction |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15473137 |
|
IRS-1 |
2004 |
Protein kinase C-zeta-induced phosphorylation of Ser318 in insulin
receptor substrate-1 (IRS-1) attenuates the interaction with the insulin
receptor and the tyrosine phosphorylation of IRS-1 |
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15069075 |
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