Proteins involved in PKC signaling pathways Chemical Reagents for PKC research 　 　
　 PKC kinases    PKC activators   PKC chromosomal Location
　 PKC phosphatases   PKC inhibitors   PKC structure
　 PKC interacting proteins        PKC transgenic mice
　 PKC substrates 　 　 　 PKC knockout mice
PKC inhibitors

    
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19903468
PKC Inhibitor Year Title Web link
3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5 -dione (AEB071) 2009 Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5 -dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19827831 
13-HODE 1999 The lipoxygenase product 13-hydroxyoctadecadienoic acid (13-HODE) is a selective inhibitor of classical PKC isoenzymes http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10079174 
AEB-071 2009 Protein kinase C inhibitor, AEB-071, acts complementarily with cyclosporine to prevent islet rejection in rats http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19136892
AEB-071 2009 The potent protein kinase C selective inhibitor AEB071 (Sotrastaurin)represents a new class of immunosuppressive agents affecting early T cell activation http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19491325
AEB071 2009 Effects of the novel protein kinase C inhibitor AEB071 (Sotrastaurin) on rat cardiac allograft survival using single agent treatment or combination therapy with cyclosporine, everolimus or FTY720 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20003043
Annexin V 1995 Inhibitory effect of annexin V on protein kinase C activity in mesangial cell lysates http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7588728 
Aprinocarsen 2004 The role of protein kinase C-alpha in malignancies of the nervous system and implications for the clinical development of the specific PKC-alpha inhibitor aprinocarsen (Review) http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14719093
ARC 2009 ARC (NSC 188491) has identical activity to Sangivamycin (NSC 65346) including inhibition of both P-TEFb and PKC http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19232100
Aprinocarsen 2004 The role of protein kinase C-alpha in malignancies of the nervous system and implications for the clinical development of the specific PKC-alpha inhibitor aprinocarsen (Review) http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14719093
Bisindolylmaleimide GF 109203X 1991 The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1874734 
bisphosphonate 2009 Protein kinase C is inhibited by bisphosphonates in prostate cancer PC-3 cells http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19903468 
Bryostatin-1 2003 Bryostatin-1: a novel PKC inhibitor in clinical development http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14735696
Bryostatin-1 2009 Phase II Study of Paclitaxel Plus the Protein Kinase C Inhibitor Bryostatin-1 in Advanced Pancreatic Carcinoma http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19738452 
BSP-A1/-A2 2003 The inhibitory effect of BSP-A1/-A2 on protein kinase C and tyrosine protein kinase http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=12736909
Butein 1998 Butein, a specific protein tyrosine kinase inhibitor http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9571170 
Calphostin C 1992 Irreversible oxidative inactivation of protein kinase C by photosensitive inhibitor calphostin C http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1281116 
Calphostin C 1997 Isoform specificity of activators and inhibitors of protein kinase C gamma and delta http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9326378 
Calphostin C 2009 Killing of cancer cells by the photoactivatable protein kinase C inhibitor, calphostin C, involves induction of endoplasmic reticulum stress http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19724676 
Chelerythrine 1990 Chelerythrine is a potent and specific inhibitor of protein kinase C http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2244923 
Chelerythrine chloride 2001 Investigation of the inhibitory effects of chelerythrine chloride on the translocation of the protein kinase C betaI, betaII, zeta in human neutrophils http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11765038
Curcumin 1993 Inhibitory effects of curcumin on protein kinase C activity induced by 12-O-tetradecanoyl-phorbol-13-acetate in NIH 3T3 cells http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8504477 
Daphnetin 1999 Daphnetin, one of coumarin derivatives, is a protein kinase inhibitor http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10403826 
Dexamethasone 2009 Dexamethasone decreases neuronal nitric oxide release in mesenteric arteries from hypertensive rats through decreased protein kinase C activation http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19267693;
Daphnetin 1999 Daphnetin, one of coumarin derivatives, is a protein kinase inhibitor http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10403826 
Enzastaurin 2009 Synergistic effect of Sorafenib and Sunitinib with Enzastaurin, a selective protein kinase C inhibitor in renal cell carcinoma cell lines http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19171421 
Enzastaurin 2009 Enzastaurin (LY317615), a Protein Kinase C Beta Selective Inhibitor, Enhances Antiangiogenic Effect of Radiation http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19906497 
Erbstatin 1990 Inhibition of protein kinase C by the tyrosine kinase inhibitor erbstatin http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2242040 
GO6976 2010 The lectin-like domain of TNF protects from listeriolysin-induced hyperpermeability in human pulmonary microvascular endothelial cells - A crucial role for protein kinase C-alpha inhibition http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20074664
H-7 1992 The structure and biological activities of the widely used protein kinase inhibitor, H7, differ depending on the commercial source http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1530623 
Hispidin 1997 Synthetic hispidin, a PKC inhibitor, is more cytotoxic toward cancer cells than normal cells in vitro http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=9088624 
Hypocrellin A 2003 Inhibitory effect of hypocrellin A on protein kinase C in liver and skeletal muscle of obese Zucker rats http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14992539
hypericin 2009 St John's Wort reduces neuropathic pain through a hypericin-mediated inhibition of the protein kinase C gamma and varepsilon activity http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20045676
LY333531 2003 Selective protein kinase C inhibitors and their applications http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=14683472
Midostaurin 2001 Protein kinase C inhibitors as novel anticancer drugs http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11772309
MT477 2009 PKC-alpha inhibitor MT477 slows tumor growth with minimal toxicity in in vivo model of non-Ras-mutated cancer via induction of apoptosis http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19795097
N-myristyl-Lys-Arg-Thr-Leu-Arg 1990 N-myristyl-Lys-Arg-Thr-Leu-Arg: a novel protein kinase C inhibitor http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2153382 
NPC 15437 1991 2,6-Diamino-N-([1-oxotridecyl)-2-piperidinyl]methyl)hexanamide (NPC 15437): a selective inhibitor of protein kinase C http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1793019 
PAP 1996 Phenylamino-pyrimidine (PAP) derivatives: a new class of potent and selective inhibitors of protein kinase C (PKC) http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8764886 
PKC412 2000 PKC412--a protein kinase inhibitor with a broad therapeutic potential http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10888033
R8605 1991 [The inhibitory effect of a third generation retinoid, R8605, on protein kinase C activity in vitro] http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1839520 
RK-286C 1990 A new inhibitor of protein kinase C, RK-286C (4'-demethylamino-4'-hydroxystaurosporine). I. Screening, taxonomy, fermentation and biological activity http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2312404 
Ro 31-8220 1996 Atypical isoforms of pKc and insulin secretion from pancreatic beta-cells: evidence using Go 6976 and Ro 31-8220 as Pkc inhibitors http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8885992 
Rottlerin 1994 Rottlerin, a novel protein kinase inhibitor http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8123051 
Rottlerin 2003 Isoform-selectivity of PKC inhibitors acting at the regulatory and catalytic domain of mammalian PKC-alpha, -betaI, -delta, -eta and -zeta http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=15008511
ruboxistaurin 2009 Inhibition of protein kinase C-beta by ruboxistaurin preserves cardiac function and reduces extracellular matrix production in diabetic cardiomyopathy http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19808328 
Sotrastaurin 2009 Sotrastaurin, a protein kinase C inhibitor for the prevention of transplant rejection and treatment of psoriasis http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19876790 
Staurosporine 1989 The protein kinase inhibitor staurosporine, like phorbol esters, induces the association of protein kinase C with membranes http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=3408497 
Staurosporine 1992 Protein kinase C-dependent and -independent actions of a potent protein kinase C inhibitor, staurosporine http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1426027 
UCN-01 1995 UCN-01, an anti-tumor drug, is a selective inhibitor of the conventional PKC subfamily http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7867810 
UCN-01 and UCN-02 1989 UCN-01 and UCN-02, new selective inhibitors of protein kinase C. I. Screening, producing organism and fermentation http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2722672 
UCN-01 and UCN-02 1989 UCN-01 and UCN-02, new selective inhibitors of protein kinase C. II. Purification, physico-chemical properties, structural determination and biological activities http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2656615 
PKC412 2008 Inhibition of PKCalpha activation in human bone and soft tissue sarcoma cells by the selective PKC inhibitor PKC412 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18507025  
Vanicosides A and B 1994 Vanicosides A and B, protein kinase C inhibitors from Polygonum pensylvanicum http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=8176400 
Verbascoside 1991 Verbascoside isolated from Lantana camara, an inhibitor of protein kinase C http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1812212 

 

Isozyme-Specific Protein Kinase C Inhibitors (IC50 values are in mM)                                                                                          Reference: Calbiochem Catalog
Product Calbiochem Cat. No.  PKCa PKCb PKCbI PKCbII PKCg PKCd PKCe PKCx PKCh PKCm Ref.
Bisindolylmaleimide I 203290 0.008 - 0.018 - - 0.21 0.132 5.8 - - 1
CGP41251 N/A 0.024 - 0.017 0.032 0.018 0.36 4.5 >1000 0.06 - 2
Gö 6976 365250 0.0023 - 0.006 - - - - - - 0.02 1
Gö 6983 365251 0.007 0.007 - - 0.006 0.01 - 0.06 - 20 3
LY333531 N/A 0.36 - 0.0047 0.0059 0.4 0.25 0.6 >105 0.052 - 4
PKCb Inhibitor 539654 0.331 - 0.021 0.005 >1.0 - 2.8 - - - 8
Ro-31-7549 557508 0.053 - 0.195 0.163 0.213 - 0.175 - - - 5
Ro-31-8220 557520 0.005 - 0.024 0.014 0.027 - 0.024 - - - 5
Ro-31-8425 557514 0.008 - 0.008 0.014 0.013 - 0.039 - - - 5
Ro-32-0432 557525 0.009 - 0.028 0.031 0.037 - 0.108 - - - 5
Rottlerin 557370 30 42 - - 40 3 - 6 100 100 - - 6
Staurosporine 569397 0.028 - 0.013 0.011 0.032 0.028 0.025 >1.5 - - 5
UCN01 N/A 0.029 - 0.034 - 0.03 0.59 0.53 - - - 7
References:                        
1. Martiny-Baron, G.M. et al. 1993. J. Biol. Chem. 268, 9194.
2. Marte, B.M., et al. 1994. Cell Growth Differ. 5, 239.
3. Gschwendt, M., et al. 1996. FEBS Lett. 392, 77.
4. Jirousek, M.R., et al. 1996. J. Med. Chem. 39, 2664.
5. Wilkinson, S.E., at al. 1993. Biochem. J. 294, 335.
6. Gschwendt, M., et al. 1994. Biochem. Biophys. Res. Commun. 199, 93.
7. Seynaeve, C.M., et al. 1994. Mol. Pharmacol. 45, 1207.
8. Tanaka, M., et al. 2004. Bioorg. Med. Chem. Lett. 14, 5171.

PKC inhibitors from AXXORA

Name Link
(-)-Epigallocatechin gallate  http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-270-263
1-O-Hexadecyl-2-O-methyl-rac-glycerol  http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-300-084
1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphocholine   http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-300-006
1-O-Octadecyl-2-O-methyl-sn-glycero-3-phosphocholine  http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-300-004
A-3   http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-270-039
BAPTA/AM   http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-450-014
Bisindolylmaleimide I   http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-270-049
Bisindolylmaleimide I   http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-270-019
Bisindolylmaleimide II   http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-270-050
Bisindolylmaleimide III  http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-270-051
Bisindolylmaleimide IV [Ro 31-6233]   http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-270-052
Bisindolylmaleimide IX   http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-270-020
Bisindolylmaleimide VI   http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-270-054
Bisindolylmaleimide VII   http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-270-055
Bisindolylmaleimide VIII  http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-270-056
Bisindolylmaleimide X   http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-270-057
Bisindolylmaleimide XI   http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-270-058
Calphostin C  http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-350-027
Chelerythrine chloride  http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-350-008
D-erythro-Sphingosine    http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-306-002
D-erythro-Sphingosine (synthetic)  http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-306-011
D-erythro-Sphingosine chloride, N,N,N-Trimethyl-   http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-306-022
D-erythro-Sphingosine, Dihydro-    http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-306-008  
D-erythro-Sphingosine, N,N-Dimethyl-   http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-306-009
Ebselen   http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-270-097
EGF Receptor (human) (651-658) (N-Myristoylated)  http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-155-022
Ganglioside GD1a  http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-302-007
Ganglioside GD1a  http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-302-008  
Gö 6976 http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-270-021   
H-7   http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-270-016
H-7, Iso-, . dihydrochloride  http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-270-040
H-89    http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-270-017
HA-100   http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-270-069
Hexadecyl-phosphocholine (C16:0) [Miltefosine]  http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-300-093
Hypericin  http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-350-030
K-252a http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-380-027
K-252b   http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-380-029
K-252c  http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-380-103 
LY-333,531  http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-270-348
MDL-27,032    http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-270-081
Melittin   http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-162-006
Melittin (synthetic) http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-162-007
ML-7   http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-270-088
ML-9   http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-270-084
NPC-15437   http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-270-104
Phloretin  http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-270-113
PKCζ Pseudosubstrate (Myristoylated)  http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-260-155
Polymyxin B . sulfate    http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-380-040
Protein Kinase C (19-31)  http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-165-009
Protein Kinase C (19-36)   http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-165-010
Pseudohypericin   http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-350-276
Quercetin    http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=JBS-INH-003
Quercetin . dihydrate   http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-385-001
Rottlerin [Mallotoxin]   http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-350-075
Staurosporine     http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=JBS-INH-005
Tamoxifen . citrate    http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-550-095
UCN-01  http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-380-222
UCN-02     http://www.axxora.com/scripts/pdf/pdf_megadetail.php3?PID=ALX-380-206 

PKC inhibitors from Calbiochem

Name Link
Bisindolylmaleimide I  http://www.emdbiosciences.com/product/print/203290
Bisindolylmaleimide I, Hydrochloride  http://www.emdbiosciences.com/product/print/203291 
Bisindolylmaleimide II  http://www.emdbiosciences.com/product/print/203292
Bisindolylmaleimide III, Hydrochloride  http://www.emdbiosciences.com/product/print/203294 
Bisindolylmaleimide IV  http://www.emdbiosciences.com/product/print/203297 
Bisindolylmaleimide V  http://www.emdbiosciences.com/product/print/203303 
Calphostin C, Cladosporium cladosporioides  http://www.emdbiosciences.com/product/print/208725 
Cardiotoxin, Naja nigricollis  http://www.emdbiosciences.com/product/print/217504 
Chelerythrine Chloride  http://www.emdbiosciences.com/product/print/220285 
Dequalinium Chloride  http://www.emdbiosciences.com/product/print/263225 
D-erythro-Sphingosine http://www.emdbiosciences.com/product/print/567726 
D-erythro-Sphingosine, Dihydro-  http://www.emdbiosciences.com/product/print/300230 
D-erythro-Sphingosine, N,N-Dimethyl http://www.emdbiosciences.com/product/print/310500 
Ellagic Acid, Dihydrate  http://www.emdbiosciences.com/product/print/324683 
Gö 6976  http://www.emdbiosciences.com/product/print/365250 
Gö 6983  http://www.emdbiosciences.com/product/print/365251 
Gö 7874, Hydrochloride  http://www.emdbiosciences.com/product/print/365252 
H-7, Dihydrochloride   http://www.emdbiosciences.com/product/print/371955
HBDDE  http://www.emdbiosciences.com/product/print/372770 
Hispidin  http://www.emdbiosciences.com/product/print/377980 
Hypericin  http://www.emdbiosciences.com/product/print/400076 
InSolution™ Bisindolylmaleimide I   http://www.emdbiosciences.com/product/print/203293 
InSolution™ Gö 6976  http://www.emdbiosciences.com/product/print/365253 
InSolution™ K-252a, Nocardiopsis sp.  http://www.emdbiosciences.com/product/print/420297 
InSolution™ Ro-31-8220  http://www.emdbiosciences.com/product/print/557521 
Iso-H-7, Dihydrochloride  http://www.emdbiosciences.com/product/print/371956 
K-252a, Nocardiopsis sp. http://www.emdbiosciences.com/product/print/ 420298 
K-252b, Nocardiopsis sp. X http://www.emdbiosciences.com/product/print/420297 
K-252c  http://www.emdbiosciences.com/product/print/420305 
Melittin  http://www.emdbiosciences.com/product/print/444605 
NGIC-I  http://www.emdbiosciences.com/product/print/481500 
Phloretin  http://www.emdbiosciences.com/product/print/524488 
Piceatannol  http://www.emdbiosciences.com/product/print/527948 
PKC 20-28, Cell-Permeable, Myristoylated  http://www.emdbiosciences.com/product/print/476480 
PKC Inhibitor Peptide 19-31  http://www.emdbiosciences.com/product/print/05-23-4904 
PKC Inhibitor Peptide 19-36  http://www.emdbiosciences.com/product/print/539560 
PKC Inhibitor, EGF-R Fragment 651-658, Myristoylated   http://www.emdbiosciences.com/product/print/476475
PKCb Inhibitor  http://www.emdbiosciences.com/product/print/539654 
PKCbII/EGFR Inhibitor  http://www.emdbiosciences.com/product/print/539652 
PKCe Translocation Inhibitor Peptide   http://www.emdbiosciences.com/product/print/539522
PKCe Translocation Inhibitor Peptide, Negative Control  http://www.emdbiosciences.com/product/print/539542 
PKCh Pseudosubstrate Inhibitor, Myristoylated  http://www.emdbiosciences.com/product/print/539604 
PKCq Pseudosubstrate Inhibitor  http://www.emdbiosciences.com/product/print/539634 
PKCq Pseudosubstrate Inhibitor, Myristoylated  http://www.emdbiosciences.com/product/print/539636 
PKCz Pseudosubstrate Inhibitor, Myristoylated  http://www.emdbiosciences.com/product/print/539624 
PKCz/i Pseudosubstrate Inhibitor  http://www.emdbiosciences.com/product/print/539610 
Polymyxin B Sulfate  http://www.emdbiosciences.com/product/print/5291 
Ro 31-7549, Immobilized  http://www.emdbiosciences.com/product/print/557509 
Ro-31-7549  http://www.emdbiosciences.com/product/print/557508 
Ro-31-8220  http://www.emdbiosciences.com/product/print/557520 
Ro-31-8425  http://www.emdbiosciences.com/product/print/557514 
Ro-32-0432  http://www.emdbiosciences.com/product/print/557525 
Rottlerin  http://www.emdbiosciences.com/product/print/557370 
Safingol  http://www.emdbiosciences.com/product/print/559300 
Sangivamycin  http://www.emdbiosciences.com/product/print/559307 
Scytonemin, Lyngbya sp.  http://www.emdbiosciences.com/product/print/565715 
Staurosporine, N-Benzoyl  http://www.emdbiosciences.com/product/print/539648 
Staurosporine, Streptomyces sp.   http://www.emdbiosciences.com/product/print/569397
Tamoxifen Citrate   http://www.emdbiosciences.com/product/print/579000
Tamoxifen, 4-Hydroxy-, (Z) http://www.emdbiosciences.com/product/print/579002 
TER14687  http://www.emdbiosciences.com/product/print/581800 
Vitamin E Succinate  http://www.emdbiosciences.com/product/print/679130 

Updated on 2012-01-25 by Seon-young Lim