Proteins involved in PKC signaling pathways Chemical Reagents for PKC research 　 　
　 PKC kinases    PKC activators   PKC chromosomal Location
　 PKC phosphatases   PKC inhibitors   PKC structure
　 PKC interacting proteins        PKC transgenic mice
　 PKC substrates 　 　 　 PKC knockout mice
PKC Structure    
PKC isoforms domain PDB Title PDB ID Reference Reference Link
PKCα C1 Solution structure of the second Phorbol esters/diacylglycerol binding domain of human Protein kinase C alpha type 2ELI  Download PDB file Solution structure of the second Phorbol esters/diacylglycerol binding domain of human Protein kinase C alpha type  
PKCγ C1 NMR structure of a protein kinase c-g phorbol-binding domain, minimized average structure 1TBN  Download PDB file NMR structure of a protein kinase C-gamma phorbol-binding domain and study of protein-lipid micelle interactions http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&dopt=AbstractPlus&list_uids=9271501
PKCγ C1 NMR structure of a protein kinase c-g phorbol-binding domain, 30 structures 1TBO  Download PDB file NMR structure of a protein kinase C-gamma phorbol-binding domain and study of protein-lipid micelle interactions http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&dopt=AbstractPlus&list_uids=9271501
PKCδ C1 Protein kinase c delta cys2 domain 1PTQ  Download PDB file  Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol ester http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&dopt=AbstractPlus&list_uids=7781068
PKCδ C1 Protein kinase c delta cys2 domain complexed with phorbol-13-acetate 1PTR  Download PDB file Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol ester http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&dopt=AbstractPlus&list_uids=7781068
PKCθ C1 Solution structure of the first C1 domain from human protein kinase C theta 2ENN  Download PDB file  Solution structure of the first C1 domain from human protein kinase C theta  
PKCα C2 C2 domain from protein kinase c (alpha) complexed with ca2+ and phosphatidylserine 1DSY  Download PDB file Ca(2+) bridges the C2 membrane-binding domain of protein kinase Calpha directly to phosphatidylserine http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&dopt=AbstractPlus&list_uids=10562545
PKCβ C2 C2 domain from protein kinase c (beta) 1A25  Download PDB file Structure of the protein kinase Cbeta phospholipid-binding C2 domain complexed with Ca2+. http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&dopt=AbstractPlus&list_uids=9817842
PKCγ C2 Crystal structure of the C2 domain of human protein kinase c gamma. 2UZP  Download PDB file 　 　
PKCδ C2 C2 domain from protein kinase c delta 1BDY   Download PDB file Crystal structure of the C2 domain from protein kinase C-delta. http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&dopt=AbstractPlus&list_uids=9687370
PKCδ C2 The C2 Domain of PKCdelta is a new Phospho-Tyrosine Binding Domain  1YRK  Download PDB file The C2 domain of PKCdelta is a phosphotyrosine binding domain http://www.ncbi.nlm.nih.gov/sites/entrez?Db=PubMed&Cmd=ShowDetailView&TermToSearch=15851033
PKCε C2 Structure of the c2 domain from novel protein kinase c epsilon 1GMI  Download PDB file Structure of the C2 domain from novel protein kinase Cepsilon. A membrane binding model for Ca(2+)-independent C2 domains. http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&dopt=AbstractPlus&list_uids=11518534
PKCη C2 Human protein kinase C, eta  2FK9  Download PDB file Structure of human protein kinase C eta (PKCeta) C2 domain and identification of phosphorylation sites http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&dopt=AbstractPlus&list_uids=16973127
PKCθ C2 Solution sturcture of the C2 domain from human protein kinase C theta 2ENJ  Download PDB file Solution sturcture of the C2 domain from human protein kinase C theta  
PKCβII Catalytic Structure of catalytic domain of human protein kinase C beta II complexed with a bisindolylmaleimide inhibitor  2I0E  Download PDB file Structure of the catalytic domain of human protein kinase C beta II complexed with a bisindolylmaleimide inhibitor http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&dopt=AbstractPlus&list_uids=17115692
PKCθ Catalytic Crystal Structure of PKC-theta complexed with Staurosporine at 2A resolution  1XJD  Download PDB file Catalytic domain crystal structure of protein kinase C-theta (PKCtheta) http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&dopt=AbstractPlus&list_uids=15364937
PKCι Catalytic Crystal Structure of the Catalytic Domain of Atypical Protein Kinase C-iota  1ZRZ  Download PDB file Crystal structure of the catalytic domain of human atypical protein kinase C-iota reveals interaction mode of phosphorylation site in turn motif. http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=16125198
PKCι PB1 Crystal structure of a PB1 domain complex of Protein kinase c iota and Par6 alpha 1WMH Download PDB file Structure of a cell polarity regulator, a complex between atypical PKC and Par6 PB1 domains http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&dopt=AbstractPlus&list_uids=15590654
PKCι PB1 Solution Structure of the PB1 domain of PKCiota  1VD2  Download PDB file Solution structure of atypical protein kinase C PB1 domain and its mode of interaction with ZIP/p62 and MEK5 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15143057

Updated on 10/04/2008 by Julhash U. Kazi